The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
High speed DNA sequencing by capillary electrophoresis
Open accessAbstract
A major challenge of the Human Genome Initiative is the development of a rapid, accurate, and efficient DNA sequencing technology. A major limitation of current technology is the relatively long time required to perform the gel electrophoretic separations of DNA fragments produced in the sequencing reactions. We demonstrate here that it is possible to increase the speed of sequence analysis by over an order of magnitude by performing the electrophoresis and detection in ultra thin capillary gels. An instrument which utilizes these high speed separations to simultaneously analyze many samples will constitute a second generation automated DNA sequencer suitable for large-scale sequence analysis.
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Citations
Cites
Fluorescence detection in automated DNA sequence analysis
Smith, L. M., Sanders, J. Z., Kaiser, R. J., Hughes, P., Dodd, C., Connell, C. R., Heiner, C., Kent, S. B. H., & Hood, L. E. (1986) · Nature · doi:10.1038/321674a0 · Cited by 1,714
Self-citationSmith, L. M., Fung, S., Hunkapiller, M. W., Hunkapiller, T. J., & Hood, L. E. (1985) · Nucleic Acids Research · doi:10.1093/nar/13.7.2399 · Cited by 342
Self-citationHigh-speed separations of DNA sequencing reactions by capillary electrophoresis
Drossman, H., Luckey, J. A., Kostichka, A. J., D'Cunha, J., & Smith, L. M. (1990) · Analytical Chemistry · doi:10.1021/ac00208a003 · Cited by 265
Self-citation
Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
The sequence of sequencers: The history of sequencing DNA
Heather, J. M., & Chain, B. (2016) · Genomics · doi:10.1016/j.ygeno.2015.11.003 · Cited by 1,397
“Both of these improvements contributed to the development of increasingly automated DNA sequencing machines [27,28,29,30,31,32,33], and subsequently the fi rst crop of commercial DNA sequencing machines [34] which were used to sequence the genomes of increasingly complex species.”
BackgroundDurney, B. C., Crihfield, C. L., & Holland, L. A. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8703-5 · Cited by 92
Next-Generation Sequencing: Advantages, Disadvantages, and Future
Ari, Ş., & Arikan, M. (2016) · Plant Omics: Trends and Applications · doi:10.1007/978-3-319-31703-8_5 · Cited by 84
Analysis of therapeutic nucleic acids by capillary electrophoresis
Wei, B., Goyon, A., & Zhang, K. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2022.114928 · Cited by 50
Metadata
- Authors
- Luckey, J. A., Drossman, H., Kostichka, A. J., Mead, D. A., D'Cunha, J., Norris, T. B., & Smith, L. M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-08-11
- Volume
- 18
- Issue
- 15
- Pages
- 4417-4421
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2105657618
- Cited by
- 262
- References
- 3
- FWCI
- 27.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Luckey, J. A., Drossman, H., Kostichka, A. J., Mead, D. A., D'Cunha, J., Norris, T. B., & Smith, L. M. (1990). High speed DNA sequencing by capillary electrophoresis. Nucleic Acids Research. https://doi.org/10.1093/nar/18.15.4417
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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