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Improved detection of helix-turn-helix DNA-binding motifs in protein sequences
Open accessAbstract
We present an update of our method for systematic detection and evaluation of potential helix-turn-helix DNA-binding motifs in protein sequences [Dodd, I. and Egan, J. B. (1987) J. Mol. Biol. 194, 557-564]. The new method is considerably more powerful, detecting approximately 50% more likely helix-turn-helix sequences without an increase in false predictions. This improvement is due almost entirely to the use of a much larger reference set of 91 presumed helix-turn-helix sequences. The scoring matrix derived from this reference set has been calibrated against a large protein sequence database so that the score obtained by a sequence can be used to give a practical estimation of the probability that the sequence is a helix-turn-helix motif.
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Cited by
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Campbell, G., & Tomlinson, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80659-5 · Cited by 278
Xiong, A., & Jayaswal, R. K. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.16.4024-4029.1998 · Cited by 100
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Kuroda, M., Hayashi, H., & Ohta, T. (1999) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1999.tb02382.x · Cited by 78
Galson, D. L., Hensold, J. O., Bishop, T. R., Schalling, M., D'Andrea, A. D., Jones, C., Auron, P. E., & Housman, D. E. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2929-2941.1993 · Cited by 45
Metadata
- Authors
- Dodd, I. B., & Egan, J. B.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1990
- Volume
- 18
- Issue
- 17
- Pages
- 5019-5026
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2063832119
- Cited by
- 519
- References
- 0
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Dodd, I. B., & Egan, J. B. (1990). Improved detection of helix-turn-helix DNA-binding motifs in protein sequences. Nucleic Acids Research. https://doi.org/10.1093/nar/18.17.5019
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