The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Transducing the Dpp Morphogen Gradient in the Wing of Drosophila
Open accessAbstract
Dpp, a TGFbeta, organizes pattern in the Drosophila wing by acting as a graded morphogen, activating different targets above distinct threshold concentrations. Like other TGFbetas, Dpp appears to induce transcription directly via activation of a SMAD, Mad. However, here we demonstrate that Dpp can also control gene expression indirectly by downregulating the expression of the brinker gene, which encodes a putative transcription factor that functions to repress Dpp targets. The medial-to-lateral Dpp gradient along the anterior-posterior axis is complemented by a lateral-to-medial gradient of Brinker, and the presence of these two opposing gradients may function to allow cells to detect small differences in Dpp concentration and respond by activating different target genes.
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Citations
Cites
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Direct and Long-Range Action of a DPP Morphogen Gradient
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Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing
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Cited by
Briscoe, J., Pierani, A., Jessell, T. M., & Ericson, J. (2000) · Cell · doi:10.1016/s0092-8674(00)80853-3 · Cited by 1,112
A Smad Transcriptional Corepressor
Wotton, D., Lo, R. S., Lee, S., & Massagué, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80712-6 · Cited by 561
Morphogen rules: design principles of gradient-mediated embryo patterning
Briscoe, J., & Small, S. (2015) · Development · doi:10.1242/dev.129452 · Cited by 490
Dpp Gradient Formation in the Drosophila Wing Imaginal Disc
Teleman, A. A., & Cohen, S. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00199-9 · Cited by 454
Moreno, E., Basler, K., & Morata, G. (2002) · Nature · doi:10.1038/416755a · Cited by 451
Metadata
- Authors
- Campbell, G., & Tomlinson, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-02
- Volume
- 96
- Issue
- 4
- Pages
- 553-562
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2041892053
- Cited by
- 278
- References
- 44
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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