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Sequence specific inhibition of DNA restriction enzyme cleavage by PNA
Open accessAbstract
Plasmids containing double-stranded 10-mer PNA (peptide nucleic acid chimera) targets proximally flanked by two restriction enzyme sites were challenged with the complementary PNA or PNAs having one or two mismatches, and the effect on the restriction enzyme cleavage of the flanking sites was assayed. The following PNAs were used: T10-LysNH2, T5CT4-LysNH2 and T2CT2CT4-LysNH2 and the corresponding targets cloned into pUC 19 were flanked by BamH1, Sal1 or Pstl sites, respectively. In all cases it was found that complete inhibition of restriction enzyme cleavage was obtained with the complementary PNA, a significantly reduced effect was seen with a PNA having one mismatch, and no effect was seen with a PNA having two mismatches. These results show that PNA can be used as sequence specific blockers of DNA recognizing proteins.
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Citations
Cites
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
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Cited by
Solid‐Phase synthesis of peptide nucleic acids
Christensen, L., Fitzpatrick, R., Gildea, B., Petersen, K. H., Hansen, H. F., Koch, T., Egholm, M., Buchardt, O., Nielsen, P. E., Coull, J., et al. (1995) · Journal of Peptide Science · doi:10.1002/psc.310010304 · Cited by 337
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Metadata
- Authors
- Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1993
- Volume
- 21
- Issue
- 2
- Pages
- 197-200
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2078197862
- Cited by
- 163
- References
- 1
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1993). Sequence specific inhibition of DNA restriction enzyme cleavage by PNA. Nucleic Acids Research. https://doi.org/10.1093/nar/21.2.197
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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