The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Solid‐Phase synthesis of peptide nucleic acids
Abstract
Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O‐(benzotriazol‐1‐yl)‐1,1,3,3‐tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc‐protected PNA monomers within 30 min. HPLC analysis of the crude product obtained from a fully automated synthesis of the model PNA oligomer H‐CGGACTAAGTCCATTGC‐Gly‐NH 2, indicated an average yield per synthetic cycle of 97.1%. N1‐benzyloxycarbonyl‐N 6 3‐methylimidazole triflate substantially outperformed acetic anhydride as a capping reagent. The resin‐bound PNAs were successfully cleaved by the ‘low–high’ trifluoromethanesulphonic acid procedure.
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Citations
Cites
Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide
Merrifield, R. B. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00897a025 · Cited by 7,647
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
Self-citationPNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S. M., Driver, D. A., Berg, R. H., Kim, S. K., Norden, B., & Nielsen, P. E. (1993) · Nature · doi:10.1038/365566a0 · Cited by 2,079
Self-citationQuantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction
Sarin, V. K., Kent, S. B. H., Tam, J. P., & Merrifield, R. B. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90704-1 · Cited by 1,065
Merrifield, B. (1986) · Science · doi:10.1126/science.3961484 · Cited by 1,005
Peptide nucleic acids (PNA). Oligonucleotide analogs with an achiral peptide backbone
Egholm, M., Buchardt, O., Nielsen, P. E., & Berg, R. H. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00031a062 · Cited by 738
Self-citationAntisense and Antigene Properties of Peptide Nucleic Acids
Hanvey, J. C., Peffer, N. J., Bisi, J. E., Thomson, S. A., Cadilla, R., Josey, J. A., Ricca, D. J., Hassman, C. F., Bonham, M. A., Au, K. G., et al. (1992) · Science · doi:10.1126/science.1279811 · Cited by 533
Single base pair mutation analysis by PNA directed PCR clamping
Ørum, H., Nielsen, P. E., Egholm, M., Berg, R. H., Buchardt, O., & Stanley, C. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.23.5332 · Cited by 334
Self-citationEgholm, M., Nielsen, P. E., Buchardt, O., & Berg, R. H. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00050a068 · Cited by 270
Self-citationSequence specific inhibition of DNA restriction enzyme cleavage by PNA
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.2.197 · Cited by 163
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Cited by
Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future
Ray, A., & Nordén, B. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.9.1041 · Cited by 416
Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression
Zhang, X., Rotllan, N., Canfrán-Duque, A., Sun, J., Toczek, J., Moshnikova, A., Malik, S., Price, N. L., Araldi, E., Zhong, W., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.320296 · Cited by 75
Metadata
- Authors
- Christensen, L., Fitzpatrick, R., Gildea, B., Petersen, K. H., Hansen, H. F., Koch, T., Egholm, M., Buchardt, O., Nielsen, P. E., Coull, J., & Berg, R. H.
- Venue
- Journal of Peptide Science
- Publisher
- Wiley
- Published
- 1995-05
- Volume
- 1
- Issue
- 3
- Pages
- 175-183
- ISSN
- 1075-2617 (ISSN-L)
- 1099-1387
- OpenAlex
- W2032178581
- Cited by
- 337
- References
- 11
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Christensen, L., Fitzpatrick, R., Gildea, B., Petersen, K. H., Hansen, H. F., Koch, T., Egholm, M., Buchardt, O., Nielsen, P. E., Coull, J., & Berg, R. H. (1995). Solid‐Phase synthesis of peptide nucleic acids. Journal of Peptide Science. https://doi.org/10.1002/psc.310010304
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
