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Modified RNA sequence pools for in vitro selection
Open accessAbstract
We report the use of modified RNA, in which the 2'-OH group of pyrimidines is replaced by a 2'-amino (2'-NH2) group to identify high affinity ligands specific for human neutrophil elastase (HNE) by in vitro selection. Compared to unmodified RNA the 2'-NH2-modified RNA ligands show enhanced stability in human serum and urine. Use of RNase T1 cleavage data in the presence of K+ and Li+ ions suggests that the modified RNA ligands selected for HNE form an intermolecular G-quartet structure.
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Citations
Cites
Isolation of New Ribozymes from a Large Pool of Random Sequences
Bartel, D. P., & Szostak, J. W. (1993) · Science · doi:10.1126/science.7690155 · Cited by 900
Cited by
Keefe, A. D., Pai, S., & Ellington, A. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3141 · Cited by 2,289
In Vitro Selection of Functional Nucleic Acids
Wilson, D. S., & Szostak, J. W. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.611 · Cited by 1,206
Analysis of aptamer discovery and technology
Dunn, M. R., Jimenez, R. M., & Chaput, J. C. (2017) · Nature Reviews Chemistry · doi:10.1038/s41570-017-0076 · Cited by 938
Rohloff, J. C., Gelinas, A. D., Jarvis, T. C., Ochsner, U. A., Schneider, D. J., Gold, L., & Janjic, N. (2014) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2014.49 · Cited by 533
Aptamers as therapeutic and diagnostic reagents: problems and prospects
Osborne, S. (1997) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(97)80102-0 · Cited by 288
Metadata
- Authors
- Lin, Y., Qiu, Q., Gill, S. C., & Jayasena, S. D.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1994
- Volume
- 22
- Issue
- 24
- Pages
- 5229-5234
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2033231386
- Cited by
- 182
- References
- 1
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Lin, Y., Qiu, Q., Gill, S. C., & Jayasena, S. D. (1994). Modified RNA sequence pools for in vitro selection. Nucleic Acids Research. https://doi.org/10.1093/nar/22.24.5229
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
