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Cited by 10,905

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence

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Lowe, Todd M., Eddy, Sean R.·1997·Nucleic Acids Research
DOI 10.1093/nar/25.5.955
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Abstract

We describe a program, tRNAscan-SE, which identifies 99-100% of transfer RNA genes in DNA sequence while giving less than one false positive per 15 gigabases. Two previously described tRNA detection programs are used as fast, first-pass prefilters to identify candidate tRNAs, which are then analyzed by a highly selective tRNA covariance model. This work represents a practical application of RNA covariance models, which are general, probabilistic secondary structure profiles based on stochastic context-free grammars. tRNAscan-SE searches at approximately 30 000 bp/s. Additional extensions to tRNAscan-SE detect unusual tRNA homologues such as selenocysteine tRNAs, tRNA-derived repetitive elements and tRNA pseudogenes.

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Cited by

Items 101–103 of 103

Metadata

Authors
Lowe, T. M., & Eddy, S. R.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
1997-03-01
Volume
25
Issue
5
Pages
955-964
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
DOI
10.1093/nar/25.5.955
OpenAlex
W2149429041
Cited by
10,905
References
1
FWCI
10.24
Type
journal article
Language
en
Open access
green

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