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The winged-helix transcription factor Trident is expressed in cycling cells
Open accessAbstract
We describe the cloning and characterization of Trident , a novel member of the fork head/winged-helix family, from murine thymus. In the mouse embryo, the gene was expressed in all tissues, whereas in adult mice expression was only detected in the thymus. Further analysis revealed that Trident expression strictly correlated with cell cycling, independent of cell type. Timing of [3H]thymidine incorporation showed that mRNA and protein expression were strongly upregulated upon entry into the S phase of the cell cycle. Moreover, the protein was phosphorylated in M phase. PCR-mediated selection of optimal binding sites yielded a consensus motif resembling that of other family members. These results identify Trident as a transcription factor, which is likely involved in cell cycle-specific gene regulation.
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Cited by
Wang, I.-C., Chen, Y.-J., Hughes, D., Petrovic, V., Major, M. L., Park, H. J., Tan, Y., Ackerson, T., & Costa, R. H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10875-10894.2005 · Cited by 627
Ratni, H., Ebeling, M., Baird, J., Bendels, S., Bylund, J., Chen, K. S., Denk, N., Feng, Z., Green, L., Guerard, M., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00741 · Cited by 537
The DREAM complex: master coordinator of cell cycle-dependent gene expression
Sadasivam, S., & DeCaprio, J. A. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3556 · Cited by 524
Fox transcription factors: from development to disease
Golson, M. L., & Kaestner, K. H. (2016) · Development · doi:10.1242/dev.112672 · Cited by 406
FoxM1: At the crossroads of ageing and cancer
Laoukili, J., Stahl, M., & Medema, R. H. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.006 · Cited by 377
Metadata
- Authors
- Korver, W., Roose, J., & Clevers, H.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-05-01
- Volume
- 25
- Issue
- 9
- Pages
- 1715-1719
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2007987759
- Cited by
- 238
- References
- 0
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Korver, W., Roose, J., & Clevers, H. (1997). The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Research. https://doi.org/10.1093/nar/25.9.1715
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