The DREAM complex: master coordinator of cell cycle-dependent gene expression

Molecular portraits of human breast tumours

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Integrated genomic analyses of ovarian carcinoma

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A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

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The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

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The Hippo pathway and human cancer

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Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors

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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF ^β-TRCP

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

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Senescence in tumours: evidence from mice and humans

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The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

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Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression

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FoxM1 is required for execution of the mitotic programme and chromosome stability

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Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP

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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

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Common markers of proliferation

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Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase

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Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

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The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene

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pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes

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The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

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Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

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Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

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Evolutionarily Conserved Multisubunit RBL2/p130 and E2F4 Protein Complex Represses Human Cell Cycle-Dependent Genes in Quiescence

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let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

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Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

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A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

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Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

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The Forkhead Box m1 Transcription Factor Stimulates the Proliferation of Tumor Cells during Development of Lung Cancer

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Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins

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A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans

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DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

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E2Fs link the control of G1/S and G2/M transcription

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Genome-scale RNAi profiling of cell division in human tissue culture cells

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FoxM1B Is Overexpressed in Human Glioblastomas and Critically Regulates the Tumorigenicity of Glioma Cells

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The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expressionPreprint

Sadasivam, S., Duan, S., & DeCaprio, J. A. (2012) · Genes & Development · doi:10.1101/gad.181933.111 · Cited by 311 · see citing works

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

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E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control

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Relationship Between Tumor Gene Expression and Recurrence in Four Independent Studies of Patients With Stage II/III Colon Cancer Treated With Surgery Alone or Surgery Plus Adjuvant Fluorouracil Plus Leucovorin

O’Connell, M. J., Lavery, I. C., Yothers, G., Paik, S., Clark-Langone, K. M., Lopatin, M., Watson, D., Baehner, F. L., Shak, S., Baker, J. B., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.9538 · Cited by 300 · see citing works

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16^ink4a

Kosar, M., Bartkova, J., Hubackova, S., Hodny, Z., Lukas, J., & Bartek, J. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14707 · Cited by 283 · see citing works

Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes

Korenjak, M., Taylor‐Harding, B., Binné, U. K., Satterlee, J. S., Nolan-Stevaux, O., Aasland, R., White‐Cooper, H., Dyson, N. J., & Brehm, A. (2004) · Cell · doi:10.1016/j.cell.2004.09.034 · Cited by 281 · see citing works

Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Progression of Prostate Carcinomas in both TRAMP and LADY Transgenic Mice

Kalin, T. V., Wang, I., Ackerson, T. J., Major, M. L., Detrisac, C. J., Kalinichenko, V. V., Lyubimov, A. V., & Costa, R. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3138 · Cited by 270 · see citing works

The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein–ubiquitin ligase SCFSkp2Preprint

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The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.

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Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complexPreprint

Lewis, P. W., Beall, E. L., Fleischer, T. C., Georlette, D., Link, A. J., & Botchan, M. R. (2004) · Genes & Development · doi:10.1101/gad.1255204 · Cited by 255 · see citing works

Introduction to the E2F Family: Protein Structure and Gene Regulation

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The winged-helix transcription factor Trident is expressed in cycling cells

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Cell cycle-dependent and cell cycle-independent control of transcription by theDrosophilaE2F/RB pathwayPreprint

Dimova, D. K., Nolan-Stevaux, O., Frolov, M. V., & Dyson, N. J. (2003) · Genes & Development · doi:10.1101/gad.1116703 · Cited by 235 · see citing works

The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

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Role for a Drosophila Myb-containing protein complex in site-specific DNA replication

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Cloning and Characterization of Mouse E2F8, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation

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Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription

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YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human diseaseThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

Wang, K., Degerny, C., Xu, M., & Yang, X.-J. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-114 · Cited by 180 · see citing works

LINC, a Human Complex That is Related to pRB-Containing Complexes in Invertebrates Regulates the Expression of G₂/M Genes

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Degradation of p27Kip cdk inhibitor triggered by Kaposi's sarcoma virus cyclin–cdk6 complex

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dpl-1 DP and efl-1 E2F Act with lin-35 Rb to Antagonize Ras Signaling in C. elegans Vulval Development

Ceol, C. J., & Horvitz, H. R. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00194-0 · Cited by 178 · see citing works

Activation of FoxM1 during G2 Requires Cyclin A/Cdk-Dependent Relief of Autorepression by the FoxM1 N-Terminal Domain

Laoukili, J., Álvarez‐Fernández, M., Meijer, L. A. T., Stahl, M., Mohammed, S., Kleij, L., Heck, A. J. R., & Medema, R. H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01710-07 · Cited by 164 · see citing works

Canonical and atypical E2Fs regulate the mammalian endocycle

Chen, H.-Z., Ouseph, M. M., Li, J., Pécot, T., Chokshi, V., Kent, L., Bae, S., Byrne, M., Duran, C., Comstock, G., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2595 · Cited by 161 · see citing works

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility

Shepard, J. L., Amatruda, J. F., Stern, H. M., Subramanian, A., Finkelstein, D., Ziai, J. M., Finley, K. R., Pfaff, K. L., Hersey, C., Zhou, Y., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506583102 · Cited by 160 · see citing works

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence

Littler, D. R., Álvarez‐Fernández, M., Stein, A., Hibbert, R. G., Heidebrecht, T., Aloy, P., Medema, R. H., & Anastassis Perrakis, A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq194 · Cited by 157 · see citing works

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

Carvajal, L. A., Hamard, P.-J., Tonnessen, C., & Manfredi, J. J. (2012) · Genes & Development · doi:10.1101/gad.184911.111 · Cited by 151 · see citing works

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex

Harrison, M. M., Ceol, C. J., Lu, X., & Horvitz, H. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608461103 · Cited by 142 · see citing works

Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb–MuvB/dREAM complex in proliferating cellsPreprint

Georlette, D., Ahn, S., MacAlpine, D. M., Cheung, E. J., Lewis, P. W., Beall, E. L., Bell, S. P., Speed, T. P., Manak, J. R., & Botchan, M. R. (2007) · Genes & Development · doi:10.1101/gad.1600107 · Cited by 142 · see citing works

B-MYB, a transcription factor implicated in regulating cell cycle, apoptosis and cancer

Sala, A. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.004 · Cited by 140 · see citing works

Biological Functions of the Genes in the Mammaprint Breast Cancer Profile Reflect the Hallmarks of Cancer

Tian, S., Roepman, P., Veer, L. J. V., Bernards, R., Snoo, F. D., & Glas, A. M. (2010) · Biomarker Insights · doi:10.4137/bmi.s6184 · Cited by 137 · see citing works

Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident

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A New Class of C. elegans synMuv Genes Implicates a Tip60/NuA4-like HAT Complex as a Negative Regulator of Ras Signaling

Ceol, C. J., & Horvitz, H. R. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00065-6 · Cited by 132 · see citing works

Proteolytic Control of the Oncoprotein Transcription Factor Myc

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Subunit Composition Determines E2F DNA-Binding Site Specificity

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Integrated genomic analyses of ovarian carcinoma

The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129 · see citing works

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescencePreprint

Aksoy, O., Chicas, A., Zeng, T., Zhao, Z., McCurrach, M. E., Wang, X., & Lowe, S. W. (2012) · Genes & Development · doi:10.1101/gad.196238.112 · Cited by 127 · see citing works

E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7

Logan, N. A., Graham, A., Zhao, X., Fisher, R., Maiti, B., Leone, G. W., & Thangue, N. B. L. (2005) · Oncogene · doi:10.1038/sj.onc.1208703 · Cited by 125 · see citing works

A kinase shRNA screen links LATS2 and the pRB tumor suppressorPreprint

Tschöp, K., Conery, A. R., Litovchick, L., DeCaprio, J. A., Settleman, J. E., Harlow, E., & Dyson, N. J. (2011) · Genes & Development · doi:10.1101/gad.2000211 · Cited by 125 · see citing works

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

Westendorp, B., Mokry, M., Groot Koerkamp, M. J. A., Holstege, F. C. P., Cuppen, E., & de Bruin, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1203 · Cited by 125 · see citing works

The central role of CDE/CHR promoter elements in the regulation of cell cycle‐dependent gene transcription

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FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer

Lam (2009) · International Journal of Oncology · doi:10.3892/ijo_00000313 · Cited by 124 · see citing works

The human synMuv‐like protein LIN‐9 is required for transcription of G2/M genes and for entry into mitosis

Osterloh, L., von Eyß, B., Schmit, F., Rein, L., Hübner, D., Samans, B., Hauser, S., & Gaubatz, S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601478 · Cited by 122 · see citing works

A role for E2F6 in distinguishing G1/S- and G2/M-specific transcriptionPreprint

Giangrande, P. H., Zhu, W., Schlisio, S., Sun, X., Mori, S., Gaubatz, S., & Nevins, J. R. (2004) · Genes & Development · doi:10.1101/gad.1239304 · Cited by 121 · see citing works

Anaphase-Promoting Complex/Cyclosome-Cdh1-Mediated Proteolysis of the Forkhead Box M1 Transcription Factor Is Critical for Regulated Entry into S Phase

Park, H. J., Costa, R. H., Lau, L. F., Tyner, A. L., & Raychaudhuri, P. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00387-08 · Cited by 118 · see citing works

Phosphorylation and activation of B-Myb by cyclin A–Cdk2

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Distinct mechanisms act in concert to mediate cell cycle arrest

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Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex

Pilkinton, M. A., Sandoval, R., & Colamonici, O. R. (2007) · Oncogene · doi:10.1038/sj.onc.1210562 · Cited by 111 · see citing works

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes

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p53 can repress transcription of cell cycle genes through a p21^WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

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A Dual Role for the dREAM/MMB Complex in the Regulation of Differentiation-Specific E2F/RB Target Genes

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