Fox transcription factors: from development to disease

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745 · see citing works

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090 · see citing works

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · see citing works

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Ross-Innes, C. S., Stark, R., Teschendorff, A. E., Holmes, K. A., Ali, H. R., Dunning, M., Brown, G. D., Gojiš, O., Ellis, I. O., Green, A. R., et al. (2012) · Nature · doi:10.1038/nature10730 · Cited by 2,182 · see citing works

A forkhead-domain gene is mutated in a severe speech and language disorder

Lai, C. S. L., Fisher, S. E., Hurst, J. A., Vargha‐Khadem, F., & Monaco, A. P. (2001) · Nature · doi:10.1038/35097076 · Cited by 2,053 · see citing works

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580 · see citing works

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

Adams, J., Palombella, V. J., Sausville, E. A., Johnson, J. I., Destree, A. T., Lazarus, D. D., Maas, J., Pien, C. S., Prakash, S., & Elliott, P. J. (1999) · PubMed · Cited by 1,457 · see citing works

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415 · see citing works

Differential Oestrogen Receptor Binding is Associated with Clinical Outcome in Breast Cancer

Stark, R. (2012) · Lecture notes in computer science · doi:10.1007/978-3-642-29627-7_30 · Cited by 1,403 · see citing works

Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1

Carroll, J. S., Liu, X. S., Brodsky, A. S., Li, W., Meyer, C. A., Szary, A. J., Eeckhoute, J., Shao, W., Hestermann, E. V., Geistlinger, T. R., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.008 · Cited by 1,384 · see citing works

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

Clark, K., Halay, E. D., Lai, E., & Burley, S. K. (1993) · Nature · doi:10.1038/364412a0 · Cited by 1,275 · see citing works

Opening of Compacted Chromatin by Early Developmental Transcription Factors HNF3 (FoxA) and GATA-4

Cirillo, L. A., Lin, F. R., Cuesta, I., Friedman, D., Jarník, M., & Zaret, K. S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00459-8 · Cited by 1,188 · see citing works

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145 · see citing works

FOXO3A genotype is strongly associated with human longevity

Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983 · see citing works

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

Lupien, M., Eeckhoute, J., Meyer, C. A., Wang, Q., Zhang, Y., Li, W., Carroll, J. S., Liu, X. S., & Brown, M. (2008) · Cell · doi:10.1016/j.cell.2008.01.018 · Cited by 983 · see citing works

HNF-3β is essential for node and notochord formation in mouse development

Ang, S., & Rossant, J. (1994) · Cell · doi:10.1016/0092-8674(94)90522-3 · Cited by 981 · see citing works

FOXA1 is a key determinant of estrogen receptor function and endocrine response

Hurtado, A., Holmes, K. A., Ross-Innes, C. S., Schmidt, D., & Carroll, J. S. (2010) · Nature Genetics · doi:10.1038/ng.730 · Cited by 847 · see citing works

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

Libina, N., Berman, J. R., & Kenyon, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00889-4 · Cited by 820 · see citing works

Redox Regulation of Forkhead Proteins Through a <i>p66shc</i> -Dependent Signaling Pathway

Nemoto, S., & Finkel, T. (2002) · Science · doi:10.1126/science.1069004 · Cited by 818 · see citing works

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo.

Weigel, D., Jürgens, G., Küttner, F., Seifert, E., & Jäckle, H. (1989) · Cell · doi:10.1016/0092-8674(89)90133-5 · Cited by 794 · see citing works

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

Weinstein, D. C., Altaba, A. R. I., Chen, W. S., Hoodless, P. A., Prezioso, V. R., Jessell, T. M., & Darnell, J. E., Jr. (1994) · Cell · doi:10.1016/0092-8674(94)90523-1 · Cited by 783 · see citing works

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

Tzivion, G., Dobson, M., & Ramakrishnan, G. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.06.002 · Cited by 728 · see citing works

Long live FOXO : unraveling the role of FOXO proteins in aging and longevity

Martins, R., Lithgow, G. J., & Link, W. (2015) · Aging Cell · doi:10.1111/acel.12427 · Cited by 728 · see citing works

Calorie restriction and aging: review of the literature and implications for studies in humans

Heilbronn, L. K., & Ravussin, E. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.361 · Cited by 701 · see citing works

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

Yang, J.-Y., Zong, C. S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J.-Y., Lai, C., Chang, C. J., Huang, W., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1676 · Cited by 698 · see citing works

The evolution of Fox genes and their role in development and disease

Hannenhalli, S., & Kaestner, K. (2009) · Nature reviews genetics · doi:10.1038/nrg2523 · Cited by 666 · see citing works

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/<i>forkhead</i> proteins

Ang, S.-L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J., & Zaret, K. S. (1993) · Development · doi:10.1242/dev.119.4.1301 · Cited by 618 · cited 1× · see citing works

Impaired Regulation of Hepatic Glucose Production in Mice Lacking the Forkhead Transcription Factor Foxo1 in Liver

Matsumoto, M., Pocai, A., Rossetti, L., DePinho, R. A., & Accili, D. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.006 · Cited by 616 · see citing works

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

Nakae, J., Biggs, W., Kitamura, T., Cavenee, W. K., Wright, C. V. E., Arden, K. C., & Accili, D. (2002) · Nature Genetics · doi:10.1038/ng890 · Cited by 616 · see citing works

The initiation of liver development is dependent on Foxa transcription factors

Lee, C. S., Friedman, J. R., Fulmer, J. T., & Kaestner, K. H. (2005) · Nature · doi:10.1038/nature03649 · Cited by 581 · see citing works

FOXO transcription factors

Carter, M. E., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.008 · Cited by 581 · see citing works

Association of <i>FOXO3A</i> variation with human longevity confirmed in German centenarians

Flachsbart, F., Caliebe, A., Kleindorp, R., Blanché, H., von Eller-Eberstein, H., Nikolaus, S., Schreiber, S., & Nebel, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809594106 · Cited by 572 · see citing works

C. elegans dauer formation and the molecular basis of plasticityPreprint

Fielenbach, N., & Antebi, A. (2008) · Genes & Development · doi:10.1101/gad.1701508 · Cited by 556 · see citing works

The role of FoxO in the regulation of metabolism

Gross, D. N., van den Heuvel, A. P. J., & Birnbaum, M. J. (2008) · Oncogene · doi:10.1038/onc.2008.25 · Cited by 555 · see citing works

FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

Kitamura, Y., Kitamura, T., Kruse, J.-P., Raum, J. C., Stein, R. W., Gu, W. J., & Accili, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.08.004 · Cited by 552 · see citing works

The Foxa family of transcription factors in development and metabolism

Friedman, J. R., & Kaestner, K. (2006) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-006-6095-6 · Cited by 541 · see citing works

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J., & Dillin, A. G. (2007) · Nature · doi:10.1038/nature05837 · Cited by 538 · see citing works

Multiple Hepatocyte-Enriched Nuclear Factors Function in the Regulation of Transthyretin and α1-Antitrypsin Genes

Costa, R. H., Grayson, D. R., & Darnell, J. E., Jr. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.4.1415 · Cited by 537 · see citing works

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501 · see citing works

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

Monaghan, A. P., Kaestner, K. H., Grau, E., & Schütz, G. (1993) · Development · doi:10.1242/dev.119.3.567 · Cited by 497 · see citing works

Incomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird Basal Ganglia Nucleus Area X

Haesler, S., Rochefort, C., Georgi, B., Licznerski, P., Osten, P., & Scharff, C. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050321 · Cited by 433 · see citing works

Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene

Shu, W., Cho, J. Y., Jiang, Y., Zhang, M., Weisz, D. J., Elder, G. A., Schmeidler, J., Gasperi, R. D., Sosa, M. A. G., Rabidou, D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503739102 · Cited by 415 · see citing works

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

Li, B., Samanta, A., Song, X., Iacono, K. T., Bembas, K., Tao, R. N., Basu, S., Riley, J. L., Hancock, W. W., Shen, Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700298104 · Cited by 410 · see citing works

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

Bramswig, N. C., Everett, L. J., Schug, J., Dorrell, C., Liu, C., Luo, Y., Streeter, P. R., Naji, A., Grompe, M., & Kaestner, K. H. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66514 · Cited by 402 · see citing works

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

Iwafuchi-Doi, M., Donahue, G., Kakumanu, A., Watts, J. A., Mahony, S., Pugh, B. F., Lee, D., Kaestner, K. H., & Zaret, K. S. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.001 · Cited by 390 · see citing works

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

Li, Z., Tuteja, G., Schug, J., & Kaestner, K. H. (2012) · Cell · doi:10.1016/j.cell.2011.11.026 · Cited by 383 · see citing works

FoxM1: At the crossroads of ageing and cancer

Laoukili, J., Stahl, M., & Medema, R. H. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.006 · Cited by 377 · see citing works

Epigenetic mechanisms of regulation of Foxp3 expression

Lal, G., & Bromberg, J. S. (2009) · Blood · doi:10.1182/blood-2009-05-219584 · Cited by 373 · see citing works

Regulation of Organogenesis by the Caenorhabditis elegans FoxA Protein PHA-4

Gaudet, J., & Mango, S. E. (2002) · Science · doi:10.1126/science.1065175 · Cited by 363 · see citing works

Characterization of a New Subfamily of Winged-helix/Forkhead (Fox) Genes That Are Expressed in the Lung and Act as Transcriptional Repressors

Shu, W., Yang, H., Zhang, L., Lu, M. M., & Morrisey, E. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100636200 · Cited by 353 · see citing works

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

Pawlikowska, L., Hu, D., Huntsman, S., Sung, A., Chu, C., Chen, J., Joyner, A. H., Schork, N. J., Hsueh, W., Reiner, A. P., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00493.x · Cited by 352 · see citing works

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.Preprint

Gao, N., Lelay, J., Vatamaniuk, M., Rieck, S., Friedman, J. R., & Kaestner, K. (2008) · Genes & Development · doi:10.1101/gad.1752608 · Cited by 338 · see citing works

Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions

Li, S., Weidenfeld, J., & Morrisey, E. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.809-822.2004 · Cited by 333 · see citing works

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations

Li, Y., Wang, W., Cao, H., Lu, J., Wu, C., Hu, F., Guo, J., Zhao, L., Yang, F., Zhang, Y.-X., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp459 · Cited by 323 · see citing works

FOXM1, a typical proliferation-associated transcription factor

Wierstra, I., & Alves, J. (2007) · Biological Chemistry · doi:10.1515/bc.2007.159 · Cited by 313 · see citing works

Cell fate control by pioneer transcription factors

Iwafuchi-Doi, M., & Zaret, K. S. (2016) · Development · doi:10.1242/dev.133900 · Cited by 304 · see citing works

Foxa2 regulates alveolarization and goblet cell hyperplasia

Wan, H.-J., Kaestner, K., Ang, S., Ikegami, M., Finkelman, F., Stahlman, M., Fulkerson, P., Rothenberg, M., & Whitsett, J. (2004) · Development · doi:10.1242/dev.00966 · Cited by 295 · see citing works

Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age

Kauffman, A., Ashraf, J. M., Corces, M. R., Landis, J. N., & Murphy, C. T. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000372 · Cited by 284 · see citing works

The Role of Hepatocyte Nuclear Factor-3α (Forkhead Box A1) and Androgen Receptor in Transcriptional Regulation of Prostatic Genes

Gao, N., Zhang, J., Rao, M. A., Case, T. C., Mirosevich, J., Wang, Y., Jin, R., Gupta, A., Rennie, P. S., & Matusik, R. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0020 · Cited by 279 · see citing works

Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell Niche

Aoki, R., Shoshkes-Carmel, M., Gao, N., Shin, S., May, C. L., Golson, M. L., Zahm, A. M., Ray, M., Wiser, C. L., Wright, C. V. E., et al. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.12.004 · Cited by 275 · see citing works

Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo.Preprint

Kaestner, K., Katz, J., Liu, Y.-F., Drucker, D., & Schütz, G. (1999) · Genes & Development · doi:10.1101/gad.13.4.495 · Cited by 253 · see citing works

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

Kittappa, R., Chang, W. W., Awatramani, R. B., & McKay, R. D. G. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050325 · Cited by 251 · see citing works

Mortality and Morbidity in Laboratory-maintained Rhesus Monkeys and Effects of Long-term Dietary Restriction

Bodkin, N. L., Alexander, T. M., Ortmeyer, H. K., Johnson, E., & Hansen, B. C. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.b212 · Cited by 250 · see citing works

Foxp1regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation

Wang, B., Weidenfeld, J., Lu, M. M., Maika, S. D., Kuziel, W. A., Morrisey, E. E., & Tucker, P. W. (2004) · Development · doi:10.1242/dev.01287 · Cited by 248 · see citing works

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2

Zuo, T., Liu, R., Zhang, H., Chang, X., Liu, Y., Wang, L., Zheng, P., & Liu, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32538 · Cited by 246 · see citing works

The winged-helix transcription factor Trident is expressed in cycling cells

Korver, W., Roose, J. P., & Clevers, H. C. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.9.1715 · Cited by 240 · see citing works

De Novo Mutations in FOXP1 in Cases with Intellectual Disability, Autism, and Language Impairment

Hamdan, F. F., Daoud, H., Rochefort, D., Piton, A., Gauthier, J., Langlois, M., Foomani, G., Dobrzeniecka, S., Krebs, M.-O., Joober, R., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.09.017 · Cited by 235 · see citing works

Multiple Domains Define the Expression and Regulatory Properties of Foxp1 Forkhead Transcriptional Repressors

Wang, B., Lin, D., Li, C., & Tucker, P. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207174200 · Cited by 231 · see citing works

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

Swindell, W. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.006 · Cited by 230 · see citing works

Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues.

Besnard, V., Wert, S., Hull, W., & Whitsett, J. (2004) · Gene Expression Patterns · doi:10.1016/j.modgep.2004.08.006 · Cited by 227 · see citing works

The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

Chen, X. X., Müller, G. A., Quaas, M., Fischer, M., Han, N., Stutchbury, B., Sharrocks, A. D., & Engeland, K. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00881-12 · Cited by 226 · see citing works

The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

Kaletsky, R. L., Lakhina, V., Arey, R. N., Williams, A. E., Landis, J. N., Ashraf, J. M., & Murphy, C. T. (2015) · Nature · doi:10.1038/nature16483 · Cited by 226 · see citing works

FOXO1 Represses Peroxisome Proliferator-activated Receptor-γ1 and -γ2 Gene Promoters in Primary Adipocytes

Armoni, M., Harel, C., Karni, S. M., Chen, H., Bar‐Yoseph, F., Ver, M. R., Quon, M. J., & Karnieli, E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600320200 · Cited by 224 · see citing works

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition

Gormally, M. V., Dexheimer, T. S., Marsico, G., Sanders, D. A., Lowe, C. E., Matak‐Vinković, D., Michael, S., Jadhav, A., Rai, G., Maloney, D. J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6165 · Cited by 223 · see citing works

Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomesPreprint

Caravaca, J. M., Donahue, G., Becker, J. S., He, X., Charles, V., & Zaret, K. S. (2013) · Genes & Development · doi:10.1101/gad.206458.112 · Cited by 218 · see citing works

The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis

Krupczak-Hollis, K., Wang, X., Kalinichenko, V. V., Gusarova, G. A., Wang, I., Dennewitz, M. B., Yoder, H. M., Kiyokawa, H., Kaestner, K. H., & Costa, R. H. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.08.022 · Cited by 213 · see citing works

FOX(M1) News—It Is Cancer

Halasi, M., & Gartel, A. L. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0712 · Cited by 210 · see citing works

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity

Riedel, C. G., Dowen, R. H., Lourenco, G. F., Kirienko, N. V., Heimbucher, T., West, J. A., Bowman, S. K., Kingston, R. E., Dillin, A., Asara, J. M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2720 · Cited by 207 · see citing works

Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System

Toth, M. L., Melentijevic, I., Shah, L., Bhatia, A., Lu, K., Talwar, A., Naji, H., Ibanez-Ventoso, C., Ghose, P., Jevince, A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1494-11.2012 · Cited by 205 · see citing works

Structure of the Forkhead Domain of FOXP2 Bound to DNA

Stroud, J. C., Wu, Y., Bates, D. L., Han, A., Nowick, K., Pääbo, S., Tong, H., & Chen, L. (2006) · Structure · doi:10.1016/j.str.2005.10.005 · Cited by 205 · see citing works

The HNF-3 Gene Family of Transcription Factors in Mice: Gene Structure, cDNA Sequence, and mRNA Distribution

Kaestner, K. H., Hiemisch, H., Luckow, B., & Schütz, G. (1994) · Genomics · doi:10.1006/geno.1994.1191 · Cited by 204 · see citing works

Foxa2 and H2A.Z Mediate Nucleosome Depletion during Embryonic Stem Cell Differentiation

Li, Z., Gadue, P. J., Chen, K., Jiao, Y., Tuteja, G., Schug, J., Li, W., & Kaestner, K. H. (2012) · Cell · doi:10.1016/j.cell.2012.11.018 · Cited by 202 · see citing works

Foxa2 is required for the differentiation of pancreatic α-cells

Lee, C. S., Sund, N. J., Behr, R., Herrera, P. L., & Kaestner, K. H. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.10.012 · Cited by 199 · see citing works

Environmentally Induced Foregut Remodeling by PHA-4/FoxA and DAF-12/NHR

Ao, W., Gaudet, J., Kent, W. J., Muttumu, S., & Mango, S. E. (2004) · Science · doi:10.1126/science.1102216 · Cited by 194 · see citing works

Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation

Gao, N., Ishii, K., Mirosevich, J., Kuwajima, S., Oppenheimer, S. R., Roberts, R. L., Jiang, M., Yu, X., Shappell, S. B., Caprioli, R. M., et al. (2005) · Development · doi:10.1242/dev.01917 · Cited by 193 · see citing works

FoxOs Function Synergistically to Promote Glucose Production

Haeusler, R. A., Kaestner, K. H., & Accili, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.175851 · Cited by 186 · see citing works

Characterization of the direct targets of<scp>FOXO</scp>transcription factors throughout evolution

Webb, A. E., Kundaje, A., & Brunet, A. (2016) · Aging Cell · doi:10.1111/acel.12479 · Cited by 182 · see citing works

Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans

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Caloric restriction and the aging process: a critique

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Foxa2 regulates multiple pathways of insulin secretion

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Foxa1 and Foxa2 Control the Differentiation of Goblet and Enteroendocrine L- and D-Cells in Mice

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The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

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FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers

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FoxO1 Stimulates Fatty Acid Uptake and Oxidation in Muscle Cells through CD36-dependent and -independent Mechanisms

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Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration

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Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence

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The Forkhead Box M1 Transcription Factor Contributes to the Development and Growth of Mouse Colorectal Cancer

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A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment

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Proteomic analyses reveal distinct chromatin‐associated and soluble transcription factor complexes

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Increased Hepatic Forkhead Box M1B (FoxM1B) Levels in Old-aged Mice Stimulated Liver Regeneration through Diminished p27Kip1 Protein Levels and Increased Cdc25B Expression

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Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour

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SnapShot:Forkhead Transcription Factors I

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The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders

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Hepatocyte Nuclear Factor 3β (Foxa2) Is Dispensable for Maintaining the Differentiated State of the Adult Hepatocyte

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Foxl1 is a marker of bipotential hepatic progenitor cells in mice†

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Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits

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The FoxM1 Transcription Factor Is Required to Maintain Pancreatic β-Cell Mass

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Molecular Analysis of a Novel Winged Helix Protein, WIN

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Role of FoxO1 in FFA-induced oxidative stress in adipocytes

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Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells

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Chromatin Opening and Stable Perturbation of Core Histone:DNA Contacts by FoxO1

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Role of the forkhead protein FoxO1 in cell compensation to insulin resistance

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SnapShot: Forkhead Transcription Factors II

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Foxa3 (Hepatocyte Nuclear Factor 3γ) Is Required for the Regulation of Hepatic GLUT2 Expression and the Maintenance of Glucose Homeostasis during a Prolonged Fast*

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Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues

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Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal inCaenorhabditis elegans

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Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2

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Multiple Hepatocyte-Enriched Nuclear Factors Function in the Regulation of Transthyretin and α1-Antitrypsin Genes

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Ubiquitous Expression of the Forkhead Box M1B Transgene Accelerates Proliferation of Distinct Pulmonary Cell Types following Lung Injury

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Advanced Cardiac Morphogenesis Does Not Require Heart Tube Fusion

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The life‐extending effect of dietary restriction requires F oxo3 in mice

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Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways

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Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasisPreprint

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Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance

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Cooperative regulation in development by SMRT and FOXP1Preprint

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Suppression of FOXM1 Sensitizes Human Cancer Cells to Cell Death Induced by DNA-Damage

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Forkhead box transcription factors in embryonic heart development and congenital heart disease

Zhu, H. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.12.001 · Cited by 91 · see citing works

FOXA2 attenuates the epithelial to mesenchymal transition by regulating the transcription of E-cadherin and ZEB2 in human breast cancer

Zhang, Z., Yang, C., Gao, W., Chen, T., Qian, T., Hu, J. X., & Tan, Y. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.03.008 · Cited by 89 · see citing works

A new target for proteasome inhibitors: FoxM1

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Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic KrasG12D

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FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

Zhang, T., Kim, D. H., Xiao, X., Lee, S., Gong, Z., Muzumdar, R. H., Calabuig-Navarro, V., Yamauchi, J., Harashima, H., Wang, R., et al. (2016) · Endocrinology · doi:10.1210/en.2015-1852 · Cited by 84 · see citing works

Expression of Foxm1 Transcription Factor in Cardiomyocytes Is Required for Myocardial Development

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Forkhead Box m1 transcription factor is required for perinatal lung function

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Regulation of adaptive behaviour during fasting by hypothalamic Foxa2

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The Forkhead Factor FoxE1 Binds to the Thyroperoxidase Promoter during Thyroid Cell Differentiation and Modifies Compacted Chromatin Structure

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The nucleosome map of the mammalian liver

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The estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness

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Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4

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Of Fox and Frogs: Fox (fork head/winged helix) transcription factors in Xenopus development

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Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus

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High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass

GANNON, M. A. (2010) · The Open Endocrinology Journal · doi:10.2174/1874216501004010066 · Cited by 71 · see citing works

The Role of the FOXP Family of Transcription Factors in ASD

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A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3β as a Novel Tumor Suppressor in Lung Cancer

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Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia

Wang, I., Zhang, Y., Snyder, J. E., Sutherland, M. J., Burhans, M. S., Shannon, J. M., Park, H. J., Whitsett, J. A., & Kalinichenko, V. V. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.027 · Cited by 69 · see citing works

Temporal Regulation of Foregut Development by HTZ-1/H2A.Z and PHA-4/FoxA

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FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice

Kobayashi, M., Kikuchi, O., Sasaki, T., Kim, H.-J., Yokota‐Hashimoto, H., Lee, Y., Amano, K., Kitazumi, T., Susanti, V. Y., Kitamura, Y., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00469.2011 · Cited by 65 · see citing works

The Role of the FOXP Family of Transcription Factors in ASD

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Parallel FoxP1 and FoxP2 Expression in Songbird and Human Brain Predicts Functional Interaction

Teramitsu, I., Kudo, L., London, S. E., Geschwind, D., & White, S. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5589-03.2004 · Cited by 64 · see citing works

FoxA1 as a lineage-specific oncogene in luminal type breast cancer

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Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms

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Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells.

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FOXA1 Promotes Tumor Progression in Prostate Cancer via the Insulin-Like Growth Factor Binding Protein 3 Pathway

Imamura, Y., Sakamoto, S., Endo, T., Utsumi, T., Fuse, M., Suyama, T., Kawamura, K., Imamoto, T., Yano, K., Uzawa, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042456 · Cited by 60 · see citing works

Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro

Wu, Q., Liu, C., Tai, M., Liu, D., Lei, L., Wang, R., Tian, M., & Lü, Y. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.4 · Cited by 60 · see citing works

FOXA2 suppresses the metastasis of hepatocellular carcinoma partially through matrix metalloproteinase-9 inhibition

Wang, J., Zhu, C.-P., Hu, P., Qian, H., Ning, B., Zhang, Q., Chen, F., Liu, J., Shi, B., Zhang, X., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu180 · Cited by 60 · see citing works

A complex regulatory network of transcription factors critical for ocular development and disease

Acharya, M., Huang, L., Fleisch, V. C., Allison, W. T., & Walter, M. A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr038 · Cited by 59 · see citing works

The Biology of FoxP3: A Key Player in Immune Suppression during Infections, Autoimmune Diseases and Cancer

Mercer, F. K., & Unutmaz, D. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1599-3_4 · Cited by 58 · see citing works

FOXP Genes, Neural Development, Speech and Language Disorders

Takahashi, H., Takahashi, K., & Liu, F. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1599-3_9 · Cited by 58 · see citing works

The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice

Spaeth, J. M., Hunter, C. S., Bonatakis, L., Guo, M. A., French, C. A., Slack, I. F., Hara, M., Fisher, S. E., Ferrer, J. P., Morrisey, E. E., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3635-3 · Cited by 56 · see citing works

Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions

Kalinina, O. A., Kalinin, S., Polack, E., Mikaelian, I., Panda, S., Costa, R. H., & Adami, G. R. (2003) · Oncogene · doi:10.1038/sj.onc.1206640 · Cited by 55 · see citing works

FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype

DeGraff, D. J., Grabowska, M. M., Case, T. C., Yu, X., Herrick, M. K., Hayward, W. J., Strand, D. W., Cates, J., Hayward, S. W., Gao, N., et al. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.64 · Cited by 51 · see citing works

The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA

Wang, M., & Gartel, A. L. (2011) · Oncotarget · doi:10.18632/oncotarget.359 · Cited by 51 · see citing works

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer

Jones, D. L., Wade, M., Nakjang, S., Chaytor, L., Grey, J., Robson, C. N., & Gaughan, L. (2015) · Oncotarget · doi:10.18632/oncotarget.4927 · Cited by 49 · see citing works

The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding

Xie, X., Stubbington, M. J. T., Nissen, J. K., Andersen, K. G., Hebenstreit, D., Teichmann, S. A., & Betz, A. G. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005251 · Cited by 43 · see citing works

Combination of Oxidative Stress and FOXM1 Inhibitors Induces Apoptosis in Cancer Cells and Inhibits Xenograft Tumor Growth

Halasi, M., Pandit, B., Wang, M., Nogueira, V., Hay, N., & Gartel, A. L. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.03.012 · Cited by 43 · see citing works

Lifespan Modulation in Mice and the Confounding Effects of Genetic Background

Mulvey, L., Sinclair, A., & Selman, C. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.06.002 · Cited by 40 · see citing works

Nuclear Mobility and Mitotic Chromosome Binding: Similarities between Pioneer Transcription Factor FoxA and Linker Histone H1Preprint

Zaret, K. S., Caravaca, J. M., Tulin, A. V., & Sekiya, T. (2010) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2010.75.061 · Cited by 38 · see citing works

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion

Golson, M. L., Dunn, J. C., Maulis, M. F., Dadi, P. K., Osipovich, A. B., Magnuson, M. A., Jacobson, D. A., & GANNON, M. A. (2015) · Diabetes · doi:10.2337/db15-0465 · Cited by 32 · see citing works

Mild Nephrogenic Diabetes Insipidus Caused by Foxa1 Deficiency

Behr, R., Brestelli, J. E., Fulmer, J. T., Miyawaki, N., Kleyman, T. R., & Kaestner, K. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403354200 · Cited by 30 · see citing works

The Transcription Factor FOXA2 Suppresses Gastric Tumorigenesis In Vitro and In Vivo

Zhu, C.-P., Wang, J., Shi, B., Hu, P., Ning, B., Zhang, Q., Chen, F., Chen, W., Zhang, X., & Xie, W. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3290-4 · Cited by 27 · see citing works

Transplanted Hepatocytes Over-expressing FoxM1B Efficiently Repopulate Chronically Injured Mouse Liver Independent of Donor Age

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A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

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FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response

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Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

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The microbiota programs DNA methylation to control intestinal homeostasis and inflammation

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The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways

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FOXM1 and Cancer: Faulty Cellular Signaling Derails Homeostasis

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FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression

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The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis

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Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance

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FOXM1: A small fox that makes more tracks for cancer progression and metastasis

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Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis

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Gender Differences in the Pathogenesis and Risk Factors of Hepatocellular Carcinoma

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Forkhead Transcription Factors in Health and Disease

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Dysregulated FOXM1 signaling in the regulation of cancer stem cells

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FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer

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FOXM1: A Multifunctional Oncoprotein and Emerging Therapeutic Target in Ovarian Cancer

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Integrative analyses of scRNA-seq and scATAC-seq reveal CXCL14 as a key regulator of lymph node metastasis in breast cancer

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Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

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FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer

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Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders

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Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones

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Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma

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FOXG1 Dose in Brain Development

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SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis

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Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer

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Dickkopf signaling, beyond Wnt-mediated biology

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The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect

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Lineage plasticity and treatment resistance in prostate cancer: the intersection of genetics, epigenetics, and evolution

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Genome‐wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads

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Zebrafish models of orofacial clefts

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Activated AMPK by metformin protects against fibroblast proliferation during pulmonary fibrosis by suppressing FOXM1

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Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer

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Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics

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The FOXO’s Advantages of Being a Family: Considerations on Function and Evolution

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Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer

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FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer

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The multisystemic functions of FOXD1 in development and disease

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FOXP1 negatively regulates tumor infiltrating lymphocyte migration in human breast cancer

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Knockdown of FOXK1 Suppresses Proliferation, Migration, and Invasion in Prostate Cancer Cells

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Molecular regulation of hematopoietic stem cell quiescence

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β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer

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Structural basis for DNA recognition by FOXC2

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FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis

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Cystic Fibrosis and the Cells of the Airway Epithelium: What Are Ionocytes and What Do They Do?

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The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers

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The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc

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Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma

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Role of FOXO3a Transcription Factor in the Regulation of Liver Oxidative Injury

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Transcription factors regulating vasculogenesis and angiogenesis

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PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells

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Genome-wide association study of blood lipids in Indians confirms universality of established variants

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FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer

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Regulation of Wnt Signaling by FOX Transcription Factors in Cancer

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The Genetics and Biology of FOXL2

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FOXM1: Functional Roles of FOXM1 in Non-Malignant Diseases

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Dynamic Foxp3–chromatin interaction controls tunable Treg cell function

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FOXP1 inhibits high glucose-induced ECM accumulation and oxidative stress in mesangial cells

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Recurrent microdeletions at chromosome 2p11.2 are associated with thymic hypoplasia and features resembling DiGeorge syndrome

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Childhood glaucoma genes and phenotypes: Focus on FOXC1 mutations causing anterior segment dysgenesis and hearing loss

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FOXI3 pathogenic variants cause one form of craniofacial microsomia

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Enhancer reprogramming in tumor progression: a new route towards cancer cell plasticity

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GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway

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Mechanism of forkhead transcription factors binding to a novel palindromic DNA site

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Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo

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FOXF2 is required for cochlear development in humans and mice

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Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment

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Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function

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USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1.

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A uniform expression library for the exploration of FOX transcription factor biology.

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Heterozygous variants that disturb the transcriptional repressor activity of FOXP4 cause a developmental disorder with speech/language delays and multiple congenital abnormalities

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FOXA1 is a determinant of drug resistance in breast cancer cells

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Single-cell insights into epithelial morphogenesis in the neonatal mouse uterus

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Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium

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A comprehensive study of arthropod and onychophoran Fox gene expression patterns

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The Fox Gene Repertoire in the Annelid Owenia fusiformis Reveals Multiple Expansions of the foxQ2 Class in Spiralia

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Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia–reperfusion injury

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Foxk1 and Foxk2 promote cardiomyocyte proliferation and heart regeneration

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SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells

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Dysregulation of miR‐431 and target gene FOXA1 in intestinal tissues of infants with necrotizing enterocolitis

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Gender differences in diet-induced steatotic disease in Cyp2b-null mice

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FOXN3 suppresses the growth and invasion of papillary thyroid cancer through the inactivation of Wnt/β-catenin pathway

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Loss of FOXO transcription factors in the liver mitigates stress-induced hyperglycemia

Whitlock, A. E. G., Sostre‐Colón, J., Gavin, M. J., Martin, N. D., Baur, J. A., Sims, C. A., & Titchenell, P. M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101246 · Cited by 27 · see citing works

FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal angiogenesis and blood-retina barrier formation

Bhakuni, T., Norden, P. R., Ujiie, N., Tan, C., Lee, S. K., Tedeschi, T. R., Hsieh, Y.-W., Wang, Y., Liu, T., Fawzi, A. A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48134-2 · Cited by 26 · see citing works

EWS ‐ FLI 1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma

Shimizu, R., Tanaka, M., Tsutsumi, S., Aburatani, H., Yamazaki, Y., Homme, M., Kitagawa, Y., & Nakamura, T. (2018) · Cancer Science · doi:10.1111/cas.13710 · Cited by 25 · see citing works

The Role of Forkhead Box Proteins in Acute Myeloid Leukemia

Gurnari, C., Falconi, G., Bellis, E. D., Voso, M. T., & Fabiani, E. (2019) · Cancers · doi:10.3390/cancers11060865 · Cited by 25 · see citing works

Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations

Dai, S., Li, J., Zhang, H., Chen, X., Guo, M., Chen, Z., & Chen, Y. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.10.007 · Cited by 24 · see citing works

Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death

Pascual-Carreras, E., Herrera-Úbeda, C., Rosselló, M., Coronel-Córdoba, P., García‐Fernàndez, J., Saló, E., & Adell, T. (2021) · Scientific Reports · doi:10.1038/s41598-020-80627-0 · Cited by 24 · see citing works

Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors

Santos‐Terra, J., Deckmann, I., Fontes‐Dutra, M., Schwingel, G. B., Bambini-Júnior, V., & Gottfried, C. (2021) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10141 · Cited by 24 · see citing works

FOXK1 regulates Wnt signalling to promote cardiogenesis

Sierra-Pagán, J. E., Dsouza, N., Das, S., Larson, T. A., Sorensen, J. R., Ma, X., Stan, P., Wanberg, E. J., Shi, X., Garry, M. G., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad054 · Cited by 24 · see citing works

Reduced glucose‐induced insulin secretion in low‐protein‐fed rats is associated with altered pancreatic islets redox status

Cappelli, A. P. G., Zoppi, C. C., Silveira, L. R., Batista, T. M., de Paula, F. M. M., Silva, P. M. R., Rafacho, A., Barbosa, H. C. L., Boschero, A. C., & Carneiro, E. M. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25908 · Cited by 24 · see citing works

Implications of Gene Inheritance Patterns on the Heterosis of Abdominal Fat Deposition in Chickens

Mai, C., Wen, C., Sun, C., Xu, Z., Chen, S., & Yang, N. (2019) · Genes · doi:10.3390/genes10100824 · Cited by 24 · see citing works

Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A

Rozanov, L. F., Ravichandran, M., Grigolon, G., Zanellati, M. C., Mansfeld, J., Zarse, K., Barzilai, N., Atzmon, G., Fischer, F., & Ristow, M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101448 · Cited by 21 · see citing works

TET2 and TET3 loss disrupts small intestine differentiation and homeostasis

Ansari, I., Solé‐Boldo, L., Ridnik, M., Gutekunst, J., Gilliam, O., Korshko, M., Liwinski, T., Jickeli, B., Weinberg-Corem, N., Shoshkes-Carmel, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39512-3 · Cited by 23 · see citing works

Chemokine signaling links cell-cycle progression and cilia formation for left–right symmetry breaking

Liu, J., Zhu, C., Ning, G., Yang, L., Cao, Y., Huang, S., & Wang, Q. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000203 · Cited by 23 · see citing works

Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain

Morrison, K. E., Cole, A. B., Kane, P. J., Meadows, V. E., Thompson, S. M., & Bale, T. L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0634-y · Cited by 23 · see citing works

FOXC1 Negatively Regulates DKK1 Expression to Promote Gastric Cancer Cell Proliferation Through Activation of Wnt Signaling Pathway

Jiang, J., Li, J., Yao, W., Wang, W., Shi, B., Yuan, F., Dong, J., & Zhang, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.662624 · Cited by 21 · see citing works

The evolution of Fox genes and their role in development and disease

Hannenhalli, S., & Kaestner, K. (2009) · Nature reviews genetics · doi:10.1038/nrg2523 · Cited by 666 · see citing works

In control of biology: of mice, men and Foxes

Wijchers, P. J., Burbach, J. P. H., & Smidt, M. P. (2006) · Biochemical Journal · doi:10.1042/bj20060387 · Cited by 139 · see citing works

Forkhead transcription factors: key players in health and disease

Benayoun, B. A., Caburet, S., & Veitia, R. A. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.03.003 · Cited by 302 · see citing works

Forkhead Transcription Factors in Health and Disease

Herman, L., Todeschini, A., & Veitia, R. A. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.11.003 · Cited by 111 · see citing works

Forkhead Transcription Factors in Genetic Disease

Baetens, D., Verdin, H., Cools, M., & Baere, E. D. (2013) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0024256 · Cited by 1 · see citing works