The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DNA condensation for gene therapy as monitored by atomic force microscopy
Open accessAbstract
The atomic force microscope (AFM) was used to assay the extent of DNA condensation in approximately 100 different complexes of DNA with polylysine (PL) or PL covalently attached to the glycoproteins asialoorosomucoid (AsOR) or orosomucoid (OR). The best condensation of DNA was obtained with 10 kDa PL covalently attached to AsOR, at a lysine:nucleotide (Lys:nt) ratio of 5:1 or higher. These conditions produce large numbers of toroids and short rods with contour lengths of 300-400 nm. Some DNA condensation into shortened thickened structures was seen with 10 kDa PL attached to AsOR at Lys:nt ratios of 1.6:1 and 3:1. Some DNA condensation was also seen with 4 kDa PL at Lys:nt ratios of 3:1 and higher. Little DNA condensation was seen with PL alone or with PL convalently attached to OR at Lys:nt ratios up to 6:1. AsOR-PL enhanced gene expression in the mouse liver approximately 10- to 50-fold as compared with PL alone.
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Cites
Nanoscopic structure of DNA condensed for gene delivery
Dunlap, D. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.3095 · Cited by 409
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Nimse, S. B., & Kim, T. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35233h · Cited by 435
Spagnou, S., Miller, A. D., & Keller, M. (2004) · Biochemistry · doi:10.1021/bi048950a · Cited by 342
Xu, L., & Anchordoquy, T. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22243 · Cited by 209
Metadata
- Authors
- Hansma, H. G., Golan, R., Hsieh, W., Lollo, C. P., Mullen-Ley, P., & Kwoh, D.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-05-01
- Volume
- 26
- Issue
- 10
- Pages
- 2481-2487
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2087589993
- Cited by
- 159
- References
- 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Hansma, H. G., Golan, R., Hsieh, W., Lollo, C. P., Mullen-Ley, P., & Kwoh, D. (1998). DNA condensation for gene therapy as monitored by atomic force microscopy. Nucleic Acids Research. https://doi.org/10.1093/nar/26.10.2481
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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