CLINICAL TRIALS AND TRANSLATIONAL MEDICINE COMMENTARY: Drug Delivery Trends in Clinical Trials and Translational Medicine: Challenges and Opportunities in the Delivery of Nucleic Acid-Based Therapeutics

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., RINGOLD, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,954 · see citing works

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805135105 · Cited by 3,037 · see citing works

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.

Cavazzana-Calvo, M., Hacein-Bey, S., Basile, G. D. S., Gross, F., Yvon, E., Nusbaum, P., Selz, F., Hue, C., Certain, S., Casanova, J., et al. (2000) · Science · doi:10.1126/science.288.5466.669 · Cited by 2,703 · see citing works

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Davis, M. E., Zuckerman, J. E., Choi, C. H. J., Seligson, D. B., Tolcher, A. W., Alabi, C. A., Yen, Y., Heidel, J. D., & Ribas, A. (2010) · Nature · doi:10.1038/nature08956 · Cited by 2,508 · see citing works

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

Soutschek, J., Akinc, A., Bramlage, B., Charissé, K., Constien, R., Donoghue, M., Elbashir, S. M., Geick, A., Hadwiger, P., Harborth, J., et al. (2004) · Nature · doi:10.1038/nature03121 · Cited by 2,189 · see citing works

Pharmacokinetics and Biodistribution of Nanoparticles

Li, S., & Huang, L. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800049w · Cited by 1,570 · see citing works

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

Perrault, S. D., Walkey, C., Jennings, T. L., Fischer, H. C., & Chan, W. C. W. (2009) · Nano Letters · doi:10.1021/nl900031y · Cited by 1,516 · see citing works

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

Cartier, N., Hacein-Bey-Abina, S., Bartholomae, C. C., Veres, G., Schmidt, M., Kutschera, I., Vidaud, M., Abel, U., Dal-Cortivo, L., Caccavelli, L., et al. (2009) · Science · doi:10.1126/science.1171242 · Cited by 1,508 · see citing works

RNAi-mediated gene silencing in non-human primates

Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., et al. (2006) · Nature · doi:10.1038/nature04688 · Cited by 1,357 · see citing works

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akinc, A., Zumbuehl, A., Goldberg, M. S., Leshchiner, E. S., Busini, V., Hossain, N., Bacallado, S., Nguyen, D. N., Fuller, J. E., Alvarez, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1402 · Cited by 1,228 · see citing works

PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

Ogris, M., Brunner, S., Schüller, S., Kircheis, R., & Wagner, E. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300900 · Cited by 1,178 · see citing works

Mechanism of DNA Release from Cationic Liposome/DNA Complexes Used in Cell Transfection,

Xu, Y., & Szoka, F. C. (1996) · Biochemistry · doi:10.1021/bi9602019 · Cited by 1,136 · see citing works

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

Gabizón, A., & Papahadjopoulos, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6949 · Cited by 1,134 · see citing works

Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models

Kirpotin, D. B., Drummond, D. C., Shao, Y., Shalaby, M. R., Hong, K., Nielsen, U. B., Marks, J. D., Benz, C. C., & Park, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4199 · Cited by 1,129 · see citing works

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

Davis, M. E. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900015y · Cited by 979 · see citing works

Cationic liposome-mediated RNA transfection.

Malone, R. W., Felgner, P. L., & Verma, I. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6077 · Cited by 911 · see citing works

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.

Nabel, G. J., Nabel, E. G., Yang, Z., Fox, B. A., Plautz, G. E., Gao, X., Huang, L., Shu, S., Gordon, D., & Chang, A. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11307 · Cited by 882 · see citing works

Condensation of DNA by multivalent cations: Considerations on mechanism

Bloomfield, V. A. (1991) · Biopolymers · doi:10.1002/bip.360311305 · Cited by 721 · see citing works

A Phase III Clinical Evaluation of Herpes Simplex Virus Type 1 Thymidine Kinase and Ganciclovir Gene Therapy as an Adjuvant to Surgical Resection and Radiation in Adults with Previously Untreated Glioblastoma Multiforme

Rainov, N. G. (2000) · Human Gene Therapy · doi:10.1089/104303400750038499 · Cited by 702 · see citing works

Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

Rozema, D. B., Lewis, D. L., Wakefield, D. H., Wong, S. C., Klein, J. J., Roesch, P. L., Bertin, S. L., Reppen, T. W., Chu, Q., Blokhin, A. V., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703778104 · Cited by 658 · see citing works

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Frank-Kamenetsky, M. D., Grefhorst, A., Anderson, N. N., Racie, T., Bramlage, B., Akinc, A., Butler, D., Charissé, K., Dorkin, J. R., Fan, Y., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805434105 · Cited by 635 · see citing works

Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes

Dams, E. T. M., Laverman, P., Oyen, W. J. G., Storm, G., Scherphof, G. L., van der Meer, J. W. M., Corstens, F. H. M., & Boerman, O. C. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35391-1 · Cited by 606 · see citing works

On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

Hafez, I., Maurer, N., & Cullis, P. R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301506 · Cited by 601 · see citing works

Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery

Plank, C., Mechtler, K., Szoka, F. C., & Wagner, E. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.12-1437 · Cited by 584 · see citing works

Design of Noninflammatory Synthetic siRNA Mediating Potent Gene Silencing in Vivo

Judge, A. D., Bola, G., Lee, A. C. H., & MacLachlan, I. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.11.002 · Cited by 571 · see citing works

Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes

Ishida, T., Ichihara, M., Wang, X., Yamamoto, K., Kimura, J., Majima, E., & Kiwada, H. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.01.005 · Cited by 558 · see citing works

Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles

Prabha, S., Zhou, W.-Z., Panyam, J., & Labhasetwar, V. D. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00315-0 · Cited by 555 · see citing works

Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes

Ishida, T., & Kiwada, H. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.11.005 · Cited by 496 · see citing works

China Approves World's First Oncolytic Virus Therapy For Cancer Treatment

Garber, K. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj111 · Cited by 489 · see citing works

Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity

Torchilin, V. P., Omelyanenko, V. G., Papisov, M. I., Bogdanov, A. A., Jr., Trubetskoy, V. S., Herron, J. N., & Gentry, C. A. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90003-5 · Cited by 466 · see citing works

Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes

Liu, D., Mori, A., & Huang, L. (1992) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(92)90136-a · Cited by 464 · see citing works

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures

Semple, S. C., Klimuk, S. K., Harasym, T. O., Dos Santos, N., Ansell, S. M., Wong, K. F., Maurer, N., Stark, H., Cullis, P. R., Hope, M. J., et al. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00343-6 · Cited by 454 · see citing works

Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes

Wang, X., Ishida, T., & Kiwada, H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.02.010 · Cited by 421 · see citing works

Introduction of liposome-encapsulated SV40 DNA into cells.

Fraley, R. T., Subramani, S. E., Berg, P. R., & Papahadjopoulos, D. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70482-7 · Cited by 416 · see citing works

Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo

Semple, S. C., Chonn, A., & Cullis, P. R. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00128-2 · Cited by 403 · see citing works

Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

Hatakeyama, H., Akita, H., Kogure, K., Oishi, M., Nagasaki, Y., Kihira, Y., Ueno, M., Kobayashi, H., Kikuchi, H., & Harashima, H. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302843 · Cited by 397 · see citing works

A Transition to a Compact Form of DNA in Polymer Solutions

Lerman, L. S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.8.1886 · Cited by 396 · see citing works

Controlling the Physical Behavior and Biological Performance of Liposome Formulations Through Use of Surface Grafted Poly(ethylene Glycol)

Allen, C. J., Santos, N. D., Gallagher, R., Chiu, G. N. C., Shu, Y., Li, W. M., Johnstone, S. A., Janoff, A. S., Mayer, L. D., Webb, M. S., et al. (2002) · Bioscience Reports · doi:10.1023/a:1020186505848 · Cited by 388 · see citing works

Epidermal Growth Factor Receptor–Targeted Immunoliposomes Significantly Enhance the Efficacy of Multiple Anticancer DrugsIn vivo

Mamot, C., Drummond, D. C., Noble, C. O., Kallab, V., Guo, Z., Hong, K., Kirpotin, D. B., & Park, J. W. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1093 · Cited by 383 · see citing works

PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner

Ishida, T., Wang, X., Shimizu, T., Nawata, K., & Kiwada, H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.015 · Cited by 382 · see citing works

Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

Akinc, A., Goldberg, M. S., Qin, J., Dorkin, J. R., Gamba‐Vitalo, C., Maier, M. A., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Manoharan, M., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.36 · Cited by 353 · see citing works

Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection

Li, S., Tseng, W.-C., Stolz, D. B., Wu, S.-Y., Watkins, S. C., & Huang, L. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300865 · Cited by 351 · see citing works

Lipidic Carriers of siRNA: Differences in the Formulation, Cellular Uptake, and Delivery with Plasmid DNA

Spagnou, S., Miller, A. D., & Keller, M. (2004) · Biochemistry · doi:10.1021/bi048950a · Cited by 343 · see citing works

Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: Relating plasma circulation lifetimes to protein binding

Santos, N. D., Allen, C. J., Doppen, A.-M., Anantha, M., Cox, K. A. K., Gallagher, R. C., Karlsson, G., Edwards, K., Kenner, G. S., Samuels, L., et al. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.12.013 · Cited by 340 · see citing works

Liposome clearance in mice: the effect of a separate and combined presence of surface charge and polymer coating

Levchenko, T. S., Rammohan, R., Lukyanov, A. N., Whiteman, K. R., & Torchilin, V. P. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00129-1 · Cited by 332 · see citing works

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials

Dewey, R. A., Morrissey, G., Cowsill, C. M., Stone, D., Bolognani, F., Dodd, N. J. F., Southgate, T. D., Klatzmann, D., Lassmann, H., Castro, M. G., et al. (1999) · Nature Medicine · doi:10.1038/15207 · Cited by 311 · see citing works

Effect of serum components on the physico-chemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells

Zelphati, O., Uyechi, L. S., Barron, L. G., & Szoka, F. C. (1998) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(97)00169-0 · Cited by 310 · see citing works

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression

Hyde, S. C., Pringle, I. A., Abdullah, S., Lawton, A. E., Davies, L. A., Varathalingam, A., Nunez-Alonso, G. A., Green, A.-M., Bazzani, R. P., Jones, S., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1399 · Cited by 308 · see citing works

A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA

Jeffs, L. B., Palmer, L. R., Ambegia, E. G., Giesbrecht, C., Ewanick, S., & MacLachlan, I. (2005) · Pharmaceutical Research · doi:10.1007/s11095-004-1873-z · Cited by 307 · see citing works

Biological Barriers to Therapy with Antisense and siRNA Oligonucleotides

Juliano, R. L., Bauman, J. A., Kang, H. M., & Ming, X. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900093r · Cited by 306 · see citing works

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake.

Perales, J. C., Ferkol, T. W., Beegen, H., Ratnoff, O. D., & Hanson, R. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4086 · Cited by 301 · see citing works

Stabilized plasmid-lipid particles: construction and characterization

Wheeler, J. J., Palmer, L., Ossanlou, M., MacLachlan, I., Graham, R. W., Zhang, Y. P., Hope, M. J., Scherrer, P., & Cullis, P. R. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300821 · Cited by 300 · see citing works

Factors Affecting the Accelerated Blood Clearance of Polyethylene Glycol-Liposomes upon Repeated Injection

Laverman, P., Carstens, M. G., Boerman, O. C., Dams, E. T. M., Oyen, W. J. G., van Rooijen, N., Corstens, F. H. M., & Storm, G. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29419-2 · Cited by 298 · see citing works

Serum opsonins and liposomes: their interaction and opsonophagocytosis.

Hm, P. (1992) · PubMed · Cited by 298 · see citing works

Overcoming the inhibitory effect of serum on lipofection by increasing the charge ratio of cationic liposome to DNA

Yang, J.-P., & Huang, L. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300485 · Cited by 293 · see citing works

Tumor-targeted gene therapy: strategies for the preparation of ligand–polyethylene glycol–polyethylenimine/DNA complexes

Ogris, M. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00230-x · Cited by 287 · see citing works

Overcoming the Innate Immune Response to Small Interfering RNA

Judge, A. D., & MacLachlan, I. (2008) · Human Gene Therapy · doi:10.1089/hum.2007.179 · Cited by 279 · see citing works

Hydrolytic Degradation of Poly(ethylene oxide)-block-Polycaprolactone Worm Micelles

Geng, Y., & Discher, D. E. (2005) · Journal of the American Chemical Society · doi:10.1021/ja053902e · Cited by 269 · see citing works

Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum

Moghimi, S. M., Muir, I. S., Illum, L., Davis, S. S., & Kolb‐Bachofen, V. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(93)90137-e · Cited by 259 · see citing works

The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey

Madden, T. D., Harrigan, P. R., Tai, L. C. L., Bally, M. B., Mayer, L. D., Redelmeier, T. E., Loughrey, H. C., Tilcock, C., Reinish, L. W., & Cullis, P. R. (1990) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(90)90131-a · Cited by 255 · see citing works

Nonviral methods for siRNA delivery

Gao, K., & Huang, L. (2009) · Molecular Pharmaceutics · doi:10.1021/mp800134q · Cited by 244 · see citing works

Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes.

Xu, L., Huang, C., Huang, W., Tang, W., Rait, A. S., Yin, Y. Z., Cruz, I., Xiang, L., Pirollo, K. F., & Chang, E. H. (2002) · PubMed · Cited by 243 · see citing works

Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo

Torchilin, V. P., Shtilman, M. I., Trubetskoy, V. S., Whiteman, K. R., & Milstein, A. M. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90025-6 · Cited by 239 · see citing works

Lipid-DNA Complexes Induce Potent Activation of Innate Immune Responses and Antitumor Activity When Administered Intravenously

DOW, S. W., Fradkin, L. G., Liggitt, D. H., Willson, A. P., Heath, T. D., & Potter, T. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1552 · Cited by 237 · see citing works

Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes

Maurer, N., Wong, K. F., Stark, H., Louie, L. J., McIntosh, D. P., Wong, T., Scherrer, P., Semple, S. C., & Cullis, P. R. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76202-9 · Cited by 232 · see citing works

Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis

Hyde, S. C., Southern, K., Gileadi, U., Fitzjohn, E., Mofford, K., Waddell, B., Gooi, H. C., Goddard, C., Hannavy, K., Smyth, S., et al. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301212 · Cited by 230 · see citing works

Delivery Vehicles for Small Interfering RNA In Vivo

de Fougerolles, A. R. (2008) · Human Gene Therapy · doi:10.1089/hum.2008.928 · Cited by 228 · see citing works

Non-viral is superior to viral gene delivery

Li, S.-D., & Huang, L. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.09.004 · Cited by 225 · see citing works

Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors

Li, S., Wu, S.-P., Whitmore, M., Loeffert, E., Wang, L., Watkins, S. C., Pitt, B. R., & Huang, L. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.276.5.l796 · Cited by 225 · see citing works

A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery

Lu, J. J.-Q., Langer, R., & Chen, J. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900023v · Cited by 219 · see citing works

Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid

Semple, S. C., Harasym, T. O., Clow, K. A., Ansell, S. M., Klimuk, S. K., & Hope, M. J. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.078113 · Cited by 211 · see citing works

Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG–lipids

Shin, J. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00232-3 · Cited by 209 · see citing works

Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle

Wolff, J. A., Dowty, M. E., Jiao, S., Repetto, G., Berg, R. K., Ludtke, J. J., Williams, P., & Slautterback, D. B. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.1249 · Cited by 204 · see citing works

LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth

Whitmore, M., Li, S., & Huang, L. (1999) · Gene Therapy · doi:10.1038/sj.gt.3301026 · Cited by 199 · see citing works

DNA Toroids: Stages in Condensation

Golan, R., Pietrasanta, L. I., Hsieh, W. J., & Hansma, H. G. (1999) · Biochemistry · doi:10.1021/bi990901o · Cited by 198 · see citing works

Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

ZHANG, J., LIU, F., & Huang, L. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.004 · Cited by 195 · see citing works

Folate-Liposome-Mediated Antisense Oligodeoxynucleotide Targeting to Cancer Cells: Evaluation in Vitro and in Vivo

Leamon, C. P., Cooper, S. R., & Hardee, G. E. (2003) · Bioconjugate Chemistry · doi:10.1021/bc020089t · Cited by 181 · see citing works

Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA−Polymer Conjugate

Meyer, M., Dohmen, C., Philipp, A. B., Kiener, D., Maiwald, G., Scheu, C., Ogris, M., & Wagner, E. (2009) · Molecular Pharmaceutics · doi:10.1021/mp9000124 · Cited by 180 · see citing works

Liposome-mediated delivery of deoxyribonucleic acid to cells: enhanced efficiency of delivery by changes in lipid composition and incubation conditions

Fraley, R. T., Straubinger, R. M., Rule, G. S., Springer, E. L., & Papahadjopoulos, D. (1981) · Biochemistry · doi:10.1021/bi00527a031 · Cited by 180 · see citing works

Interaction between DNA–cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid

Sakurai, F., Nishioka, T., Saito, H., Baba, T., Okuda, A., Matsumoto, O., Taga, T., Yamashita, F., Takakura, Y., & Hashida, M. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301460 · Cited by 175 · see citing works

Comparison of different hydrophobic anchors conjugated to poly(ethylene glycol): effects on the pharmacokinetics of liposomal vincristine

Webb, M. S., Saxon, D., Wong, F. M. P., Lim, H. J., Wang, Z., Bally, M. B., Choi, L. S. L., Cullis, P. R., & Mayer, L. D. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00077-7 · Cited by 171 · see citing works

DNA condensation for gene therapy as monitored by atomic force microscopy

Hansma, H. G., Golan, R., Hsieh, K., Lollo, C. P., Mullen-Ley, P., & Kwoh, D. Y. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.10.2481 · Cited by 159 · see citing works

Oncolytic virotherapy for cancer with the adenovirus dl1520 (Onyx-015): results of Phase I and II trials

Kirn, D. H. (2001) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.1.3.525 · Cited by 159 · see citing works

Structure and Gene Silencing Activities of Monovalent and Pentavalent Cationic Lipid Vectors Complexed with siRNA

Bouxsein, N. F., McAllister, C. S., Ewert, K. K., Samuel, C. E., & Safinya, C. R. (2007) · Biochemistry · doi:10.1021/bi062138l · Cited by 155 · see citing works

Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum

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