The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A DNA polymerase stop assay for G-quadruplex-interactive compounds
Open accessAbstract
We have developed and characterized an assay for G-quadruplex-interactive compounds that makes use of the fact that G-rich DNA templates present obstacles to DNA synthesis by DNA polymerases. Using Taq DNA polymerase and the G-quadruplex binding 2, 6-diamidoanthraquinone BSU-1051, we find that BSU-1051 leads to enhanced arrest of DNA synthesis in the presence of K+by stabilizing an intramolecular G-quadruplex structure formed by four repeats of either TTGGGG or TTAGGG in the template strand. The data provide additional evidence that BSU-1051 modulates telomerase activity by stabilization of telomeric G-quadruplex DNA and point to a polymerase arrest assay as a sensitive method for screening for G-quadruplex-interactive agents with potential clinical utility.
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Citations
Cites
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound
Sun, D., Thompson, B., Cathers, B. E., Salazar, M., Kerwin, S. M., Trent, J. O., Jenkins, T. C., Neidle, S., & Hurley, L. H. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970199z · Cited by 794
Self-citation
Cited by
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
Huppert, J. L. (2008) · Chemical Society Reviews · doi:10.1039/b702491f · Cited by 494
Dexheimer, T. S., Sun, D., & Hurley, L. H. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0563861 · Cited by 383
Self-citationIdentification and Characterization of Nucleolin as a c-myc G-quadruplex-binding Protein
González, V., Guo, K., Hurley, L., & Sun, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018028 · Cited by 321
Self-citationReevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action
De Cian, A., Cristofari, G., Reichenbach, P., De Lemos, E., Monchaud, D., Teulade-Fichou, M.-P., Shin-ya, K., Lacroix, L., Lingner, J., & Mergny, J.-L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707365104 · Cited by 292
Xu, H., & Hurley, L. H. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.129016 · Cited by 84
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Metadata
- Authors
- Han, H., Hurley, L. H., & Salazar, M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01-01
- Volume
- 27
- Issue
- 2
- Pages
- 537-542
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2045300344
- Cited by
- 235
- References
- 2
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Han, H., Hurley, L. H., & Salazar, M. (1999). A DNA polymerase stop assay for G-quadruplex-interactive compounds. Nucleic Acids Research. https://doi.org/10.1093/nar/27.2.537
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