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Mouse genome database (MGD): Knowledgebase for mouse-human comparative biology

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Blake, Judith A, Baldarelli, Richard, Kadin, James A, Richardson, Joel E, Smith, Cynthia L, Bult, Carol J, the Mouse Genome Database Group, Anagnostopoulos, Anna V +30 more·2021·Nucleic Acids Research
DOI 10.1093/nar/gkaa1083PMC PMC7779030
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Abstract

The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism knowledgebase for the laboratory mouse, a widely used animal model for comparative studies of the genetic and genomic basis for human health and disease. MGD is the authoritative source for biological reference data related to mouse genes, gene functions, phenotypes and mouse models of human disease. MGD is the primary source for official gene, allele, and mouse strain nomenclature based on the guidelines set by the International Committee on Standardized Nomenclature for Mice. MGD’s biocuration scientists curate information from the biomedical literature and from large and small datasets contributed directly by investigators. In this report we describe significant enhancements to the content and interfaces at MGD, including (i) improvements in the Multi Genome Viewer for exploring the genomes of multiple mouse strains, (ii) inclusion of many more mouse strains and new mouse strain pages with extended query options and (iii) integration of extensive data about mouse strain variants. We also describe improvements to the efficiency of literature curation processes and the implementation of an information portal focused on mouse models and genes for the study of COVID-19.

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Crossref · 10.1093/nar/gkaa1083

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  • CAST, PWK, and WSB mice contain millions of variants across the mouse genome.

    “CAST, PWK, and WSB mice contain millions of variants across the mouse genome (Blake et al., 2021).”

    From Network analysis identifies strain-dependent response to tau and tau seeding-associated genes (2023) · cites this paper as Blake et al., 2021

    The section “Strain group comparisons for murine SNP data” (page not provided) says MGD contains almost 16 million SNPs from 88 mouse strains. It does not identify CAST, PWK, or WSB or establish that those particular strains each contain millions of variants. (LLM, conf=0.84)

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Research works printed but not linked: 16

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Authors
Blake, J. A., Baldarelli, R., Kadin, J. A., Richardson, J. E., Smith, C. L., Bult, C. J., the Mouse Genome Database Group, Anagnostopoulos, A. V., Beal, J. S., Bello, S. M., Blodgett, O., Butler, N. E., Campbell, J., Christie, K. R., Corbani, L. E., Dolan, M. E., Drabkin, H. J., Flores, M., Giannatto, S. L., Guerra, A., Hale, P., Hill, D. P., Judd, J., Law, M., McAndrews, M., Miers, D., Mitchell, C., Motenko, H., Ni, L., Onda, H., Ormsby, J., Perry, M., Recla, J. M., Shaw, D., Sitnikov, D., Tomczuk, M., Wilming, L., & Zhu, Y. ‘.
Affiliations
Jackson Laboratory (US)
Corresponding author
Blake, Judith A
ORCID
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2020-11-24
Volume
49
Issue
D1
Pages
D981-D987
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
DOI
10.1093/nar/gkaa1083
PMC
PMC7779030
OpenAlex
W3108679240
Cited by
422
References
4
Citations by year
2026: 45 · 2025: 80 · 2024: 160 · 2023: 104 · 2022: 21 · 2021: 10 · 2020: 1 · 2019: 1
FWCI
11.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Nucleic Acids Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion, cc-by)
Funders
  • National Institutes of Health
  • National Human Genome Research Institute (U41 HG000330, R25 HG007053)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords
Mouse Genome Database, gene nomenclature, allele nomenclature, mouse models of human disease, literature curation, gene function, phenotypes
MeSH terms
COVID-19, SARS-CoV-2, Animals, Disease Models, Animal, Humans, Information Storage and Retrieval, Genome, Internet, Genomics, Databases, Genetic, Knowledge Bases, Mice, Epidemics, Gene Ontology, Data Curation

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