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DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides

Open access
Shi, Guobang, Kang, Xinyue, Dong, Fanyi, Liu, Yanchao, Zhu, Ning, Hu, Yuxuan, Xu, Hanmei, Lao, Xingzhen, Zheng, Heng·2022·Nucleic Acids Research

Abstract

Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules which have antimicrobial activity and potent structure stability. We previously published the Data Repository of Antimicrobial Peptides (DRAMP) as a manually annotated and open-access database of antimicrobial peptides (AMPs). In the update of version 3.0, special emphasis was placed on the new development of stapled AMPs, and a subclass of specific AMPs was added to store information on these special chemically modified AMPs. To help design low toxicity AMPs, we also added the cytotoxicity property of AMPs, as well as the expansion of newly discovered AMP data. At present, DRAMP has been expanded and contains 22259 entries (2360 newly added), consisting of 5891 general entries, 16110 patent entries, 77 clinical entries and 181 stapled AMPs. A total of 263 entries have predicted structures, and more than 300 general entries have links to experimentally determined structures in the Protein Data Bank. The update also covers new annotations, statistics, categories, functions and download links. DRAMP is available online at http://dramp.cpu-bioinfor.org/.

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Metadata

Authors
Shi, G., Kang, X., Dong, F., Liu, Y., Zhu, N., Hu, Y., Xu, H., Lao, X., & Zheng, H.
Venue
Nucleic Acids Research
Published
2021-08-14
Volume
50
Issue
D1
Pages
D488-D496
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W3188372451
Cited by
308
References
44
FWCI
24.33
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides. https://app.cochat.ai/papers/10.1093/nar/gkab651
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Shi, G., Kang, X., Dong, F., Liu, Y., Zhu, N., Hu, Y., Xu, H., Lao, X., & Zheng, H. (2022). DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides. Nucleic Acids Research. https://doi.org/10.1093/nar/gkab651

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