The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix
Open accessAbstract
Human telomeric DNA composed of (TTAGGG/CCCTAA)n repeats may form a classical Watson-Crick double helix. Each individual strand is also prone to quadruplex formation: the G-rich strand may adopt a G-quadruplex conformation involving G-quartets whereas the C-rich strand may fold into an i-motif based on intercalated C*C+ base pairs. Using an equimolar mixture of the telomeric oligonucleotides d[AGGG(TTAGGG)3] and d[(CCCTAA)3CCCT], we defined which structures existed and which would be the predominant species under a variety of experimental conditions. Under near-physiological conditions of pH, temperature and salt concentration, telomeric DNA was predominantly in a double-helix form. However, at lower pH values or higher temperatures, the G-quadruplex and/or the i-motif efficiently competed with the duplex. We also present kinetic and thermodynamic data for duplex association and for G-quadruplex/i-motif unfolding.
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Citations
Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1×
“In contrast to cancer cells, which often express high levels of telomerase ( 3 ), this activity is tightly regulated in normal human somatic cells (reviewed in 4). In a large number of organisms, telomeric DNA consists of highly repetitive short sequences.”
BackgroundTelomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Mammalian Telomeres End in a Large Duplex Loop
Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447
Cited by
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
Huppert, J. L. (2008) · Chemical Society Reviews · doi:10.1039/b702491f · Cited by 494
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Multistep mechanism of G-quadruplex resolution during DNA replication
Sato, K., Martin-Pintado, N., Post, H., Altelaar, M., & Knipscheer, P. (2021) · Science Advances · doi:10.1126/sciadv.abf8653 · Cited by 80
Metadata
- Authors
- Phan, A. T.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 30
- Issue
- 21
- Pages
- 4618-4625
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2105669930
- Cited by
- 471
- References
- 3
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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