The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Variation in the strength of selected codon usage bias among bacteria
Open accessAbstract
Among bacteria, many species have synonymous codon usage patterns that have been influenced by natural selection for those codons that are translated more accurately and/or efficiently. However, in other species selection appears to have been ineffective. Here, we introduce a population genetics-based model for quantifying the extent to which selection has been effective. The approach is applied to 80 phylogenetically diverse bacterial species for which whole genome sequences are available. The strength of selected codon usage bias, S, is found to vary substantially among species; in 30% of the genomes examined, there was no significant evidence that selection had been effective. Values of S are highly positively correlated with both the number of rRNA operons and the number of tRNA genes. These results are consistent with the hypothesis that species exposed to selection for rapid growth have more rRNA operons, more tRNA genes and more strongly selected codon usage bias. For example, Clostridium perfringens, the species with the highest value of S, can have a generation time as short as 7 min.
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Metadata
- Authors
- Sharp, P. M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02-23
- Volume
- 33
- Issue
- 4
- Pages
- 1141-1153
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2143221412
- Cited by
- 429
- References
- 62
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- gold
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