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NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis

Open access
Lindahl, E., Azuara, C., Koehl, P., Delarue, M.·2006·Nucleic Acids Research

Abstract

Normal mode analysis (NMA) is an efficient way to study collective motions in biomolecules that bypasses the computational costs and many limitations associated with full dynamics simulations. The NOMAD-Ref web server presented here provides tools for online calculation of the normal modes of large molecules (up to 100,000 atoms) maintaining a full all-atom representation of their structures, as well as access to a number of programs that utilize these collective motions for deformation and refinement of biomolecular structures. Applications include the generation of sets of decoys with correct stereochemistry but arbitrary large amplitude movements, the quantification of the overlap between alternative conformations of a molecule, refinement of structures against experimental data, such as X-ray diffraction structure factors or Cryo-EM maps and optimization of docked complexes by modeling receptor/ligand flexibility through normal mode motions. The server can be accessed at the URL http://lorentz.immstr.pasteur.fr/nomad-ref.php.

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Metadata

Authors
Lindahl, E., Azuara, C., Koehl, P., & Delarue, M.
Venue
Nucleic Acids Research
Published
2006-07-01
Volume
34
Issue
Web Server
Pages
W52-W56
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2107268733
Cited by
309
References
27
FWCI
6.63
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis. https://app.cochat.ai/papers/10.1093/nar/gkl082
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Lindahl, E., Azuara, C., Koehl, P., & Delarue, M. (2006). NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis. Nucleic Acids Research. https://doi.org/10.1093/nar/gkl082

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