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Cited by 512

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization

Open access
Yuan, H.-Y., Chiou, J.-J., Tseng, W.-H., Liu, C.-H., Liu, C.-K., Lin, Y.-J., Wang, H.-H., Yao, A., Chen, Y.-T., Hsu, C.-N.·2006·Nucleic Acids Research
DOI 10.1093/nar/gkl236
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Abstract

Single nucleotide polymorphism (SNP) prioritization based on the phenotypic risk is essential for association studies. Assessment of the risk requires access to a variety of heterogeneous biological databases and analytical tools. FASTSNP (function analysis and selection tool for single nucleotide polymorphisms) is a web server that allows users to efficiently identify and prioritize high-risk SNPs according to their phenotypic risks and putative functional effects. A unique feature of FASTSNP is that the functional effect information used for SNP prioritization is always up-to-date, because FASTSNP extracts the information from 11 external web servers at query time using a team of web wrapper agents. Moreover, FASTSNP is extendable by simply deploying more Web wrapper agents. To validate the results of our prioritization, we analyzed 1569 SNPs from the SNP500Cancer database. The results show that SNPs with a high predicted risk exhibit low allele frequencies for the minor alleles, consistent with a well-known finding that a strong selective pressure exists for functional polymorphisms. We have been using FASTSNP for 2 years and FASTSNP enables us to discover a novel promoter polymorphism. FASTSNP is available at http://fastsnp.ibms.sinica.edu.tw.

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Metadata

Authors
Yuan, H.-Y., Chiou, J.-J., Tseng, W.-H., Liu, C.-H., Liu, C.-K., Lin, Y.-J., Wang, H.-H., Yao, A., Chen, Y.-T., & Hsu, C.-N.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2006-07-01
Volume
34
Issue
Web Server
Pages
W635-W641
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
DOI
10.1093/nar/gkl236
OpenAlex
W2149385661
Cited by
512
References
3
FWCI
13.78
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. https://app.cochat.ai/papers/10.1093/nar/gkl236
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Yuan, H.-Y., Chiou, J.-J., Tseng, W.-H., Liu, C.-H., Liu, C.-K., Lin, Y.-J., Wang, H.-H., Yao, A., Chen, Y.-T., & Hsu, C.-N. (2006). FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Research. https://doi.org/10.1093/nar/gkl236

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