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Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies
Open accessAbstract
In Caenorhabditis elegans, the Mex-3 protein is a translational regulator that specifies the posterior blastomere identity in the early embryo and contributes to the maintenance of the germline totipotency. We have now identified a family of four homologous human Mex-3 genes, called hMex-3A to -3D that encode proteins containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. The hMex-3 are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1-dependent export pathway. Our analysis further revealed that hMex-3A and hMex-3B, but not hMex-3C, colocalize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover. Taken together, these findings indicate that hMex-3 proteins constitute a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms.
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Gibbings, D. J., Ciaudo, C., Erhardt, M., & Voinnet, O. (2009) · Nature Cell Biology · doi:10.1038/ncb1929 · Cited by 991
RNA-Binding Proteins in Cancer: Old Players and New Actors
Pereira, B., Billaud, M., & Almeida, R. (2017) · Trends in Cancer · doi:10.1016/j.trecan.2017.05.003 · Cited by 773
Self-citationScaffold function of long non-coding RNA HOTAIR in protein ubiquitination
Yoon, J.-H., Abdelmohsen, K., Kim, J., Yang, X., Martindale, J. L., Tominaga-Yamanaka, K., White, E. J., Orjalo, A. V., Rinn, J. L., Kreft, S. G., et al. (2013) · Nature Communications · doi:10.1038/ncomms3939 · Cited by 458
Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases
Groot, M., & Lee, H. (2020) · Cells · doi:10.3390/cells9041044 · Cited by 364
Baumgart, M., Groth, M., Priebe, S., Savino, A., Testa, G., Dix, A., Ripa, R., Spallotta, F., Gaetano, C., Ori, M., et al. (2014) · Aging Cell · doi:10.1111/acel.12257 · Cited by 167
Metadata
- Authors
- Buchet-Poyau, K., Courchet, J., Hir, H. L., Seraphin, B., Scoazec, J.-Y., Duret, L., Domon-Dell, C., Freund, J.-N., & Billaud, M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-01-30
- Volume
- 35
- Issue
- 4
- Pages
- 1289-1300
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2144851403
- Cited by
- 170
- References
- 3
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- gold
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- Buchet-Poyau, K., Courchet, J., Hir, H. L., Seraphin, B., Scoazec, J.-Y., Duret, L., Domon-Dell, C., Freund, J.-N., & Billaud, M. (2007). Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Research. https://doi.org/10.1093/nar/gkm016
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