The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination
Open accessAbstract
Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence. These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination. The long non-coding RNA HOTAIR acts as a scaffold to bring together chromatin silencing complexes in the nucleus. Here, the authors show that HOTAIRalso serves as a scaffold between E3 ubiquitin ligases and their substrates and thereby enhances their ubiquitination.
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Cites
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
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Self-citationGenome Regulation by Long Noncoding RNAs
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Self-citationMammalian microRNAs predominantly act to decrease target mRNA levels
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Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
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A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
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lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements
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History, Discovery, and Classification of lncRNAs
Jarroux, J., Morillon, A., & Pinskaya, M. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-10-5203-3_1 · Cited by 865
Circular RNAs: analysis, expression and potential functions
Barrett, S. P., & Salzman, J. (2016) · Development · doi:10.1242/dev.128074 · Cited by 859
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1
Abdelmohsen, K., Panda, A. C., Munk, R., Grammatikakis, I., Dudekula, D. B., De, S., Kim, J., Noh, J. H., Kim, K. M., Martindale, J. L., et al. (2017) · RNA Biology · doi:10.1080/15476286.2017.1279788 · Cited by 858
Self-citationLong noncoding RNA MALAT1 suppresses breast cancer metastasis
Kim, J., Piao, H.-L., Kim, B.-J., Yao, F., Han, Z., Wang, Y., Xiao, Z., Siverly, A. N., Lawhon, S. E., Ton, B. N., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0252-3 · Cited by 771
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Metadata
- Authors
- Yoon, J.-H., Abdelmohsen, K., Kim, J., Yang, X., Martindale, J. L., Tominaga-Yamanaka, K., White, E. J., Orjalo, A. V., Rinn, J. L., Kreft, S. G., Wilson, G. M., & Gorospe, M.
- Venue
- Nature Communications
- Published
- 2013-12-11
- Volume
- 4
- Issue
- 1
- Pages
- 2939-2939
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2082268152
- Cited by
- 458
- References
- 38
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yoon, J.-H., Abdelmohsen, K., Kim, J., Yang, X., Martindale, J. L., Tominaga-Yamanaka, K., White, E. J., Orjalo, A. V., Rinn, J. L., Kreft, S. G., Wilson, G. M., & Gorospe, M. (2013). Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Nature Communications. https://doi.org/10.1038/ncomms3939
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