The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
DNA damage, cellular senescence and organismal ageing: causal or correlative?
Open accessAbstract
Cellular senescence has long been used as a cellular model for understanding mechanisms underlying the ageing process. Compelling evidence obtained in recent years demonstrate that DNA damage is a common mediator for both replicative senescence, which is triggered by telomere shortening, and premature cellular senescence induced by various stressors such as oncogenic stress and oxidative stress. Extensive observations suggest that DNA damage accumulates with age and that this may be due to an increase in production of reactive oxygen species (ROS) and a decline in DNA repair capacity with age. Mutation or disrupted expression of genes that increase DNA damage often result in premature ageing. In contrast, interventions that enhance resistance to oxidative stress and attenuate DNA damage contribute towards longevity. This evidence suggests that genomic instability plays a causative role in the ageing process. However, conflicting findings exist which indicate that ROS production and oxidative damage levels of macromolecules including DNA do not always correlate with lifespan in model animals. Here we review the recent advances in addressing the role of DNA damage in cellular senescence and organismal ageing.
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Cites
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Cited by
Early Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?
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Taking a good look at free radicals in the aging process
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Buford, T. W. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.007 · Cited by 561
Biomarkers of cellular senescence and skin aging
Wang, A. S., & Dreesen, O. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00247 · Cited by 404
Mechanisms involved in the developmental programming of adulthood disease
Warner, M. J., & Ozanne, S. E. (2010) · Biochemical Journal · doi:10.1042/bj20091861 · Cited by 316
Self-citation
Metadata
- Authors
- Chen, J.-H., Hales, C. N., & Ozanne, S. E.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-26
- Volume
- 35
- Issue
- 22
- Pages
- 7417-7428
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2134461109
- Cited by
- 476
- References
- 58
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- gold
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