Taking a good look at free radicals in the aging process

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

The Free Radical Theory of Aging Matures

BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works

Mitochondrial free radical generation, oxidative stress, and aging

Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010 · see citing works

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520 · see citing works

Reconciling the chemistry and biology of reactive oxygen species

Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504 · see citing works

Cellular defenses against damage from reactive oxygen species

Yu, B. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.139 · Cited by 2,378 · see citing works

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works

The Biologic Clock: The Mitochondria?

Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 1,991 · see citing works

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789 · see citing works

Redox regulation of cell survival

Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781 · see citing works

Hydrogen peroxide sensing and signaling

Veal, E. A., Day, A. M., & Morgan, B. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.016 · Cited by 1,604 · see citing works

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

Qiu, X., Brown, K., Hirschey, M. D., Verdin, E., & Chen, D. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.015 · Cited by 1,310 · see citing works

Regulation of autophagy by ROS: physiology and pathology

Scherz-Shouval, R., & Elazar, Z. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.007 · Cited by 1,263 · see citing works

The sites and topology of mitochondrial superoxide production

Brand, M. D. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.003 · Cited by 1,217 · see citing works

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209 · see citing works

Molecular inflammation: Underpinnings of aging and age-related diseases

Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203 · see citing works

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

Fraga, C. G., Shigenaga, M. K., Park, J. W., Degan, P., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4533 · Cited by 1,106 · see citing works

Trends in oxidative aging theories

Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011 · see citing works

Lipid peroxidation: Physiological levels and dual biological effects

Niki, E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.032 · Cited by 1,006 · see citing works

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789 · see citing works

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

Azad, M. B., Chen, Y., & Gibson, S. B. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2270 · Cited by 761 · see citing works

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734 · see citing works

Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans

Feng, J., Bussière, F., & Hekimi, S. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00071-5 · Cited by 675 · see citing works

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

Elchuri, S., Oberley, T. D., Qi, W., Eisenstein, R. S., Jackson Roberts, L., Van Remmen, H., Epstein, C. J., & Huang, T.-T. (2005) · Oncogene · doi:10.1038/sj.onc.1208207 · Cited by 667 · see citing works

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

Yang, W., & Hekimi, S. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000556 · Cited by 630 · see citing works

Is the oxidative stress theory of aging dead?

Pérez, V. I., Bokov, A., Remmen, H. V., Mele, J., Ran, Q., Ikeno, Y., & Richardson, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.003 · Cited by 604 · see citing works

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

Trifunovic, A., Hansson, A., Wredenberg, A., Rovio, A. T., Dufour, E., Khvorostov, I., Spelbrink, J. N., Wibom, R., Jacobs, H. T., & Larsson, N.-G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508886102 · Cited by 555 · see citing works

Somatic Mitochondrial DNA Mutations in Mammalian Aging

Larsson, N. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060408-093701 · Cited by 543 · see citing works

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

Van Raamsdonk, J. M., & Hekimi, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000361 · Cited by 511 · see citing works

Global Impairment of the Ubiquitin-Proteasome System by Nuclear or Cytoplasmic Protein Aggregates Precedes Inclusion Body Formation

Bennett, E. J., Bence, N., Rajadas, J., & Kopito, R. R. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.021 · Cited by 509 · see citing works

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

Lee, S., Hwang, A. B., & Kenyon, C. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.057 · Cited by 495 · see citing works

DNA damage, cellular senescence and organismal ageing: causal or correlative?

Chen, J.-H., Hales, C. N., & Ozanne, S. E. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm681 · Cited by 481 · see citing works

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegansPreprint

Doonan, R., McElwee, J., Matthijssens, F., Walker, G. A., Houthoofd, K., Back, P., Matscheski, A., Vanfleteren, J. R., & Gems, D. (2008) · Genes & Development · doi:10.1101/gad.504808 · Cited by 480 · see citing works

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

Sun, J., & Tower, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.216 · Cited by 467 · see citing works

The wanderings of a free radical

Halliwell, B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.008 · Cited by 467 · see citing works

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

Pérez, V. I., Buffenstein, R., Masamsetti, V., Leonard, S., Salmon, A. B., Mele, J., Andziak, B., Yang, T., Edrey, Y., Friguet, B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809620106 · Cited by 418 · see citing works

Antioxidants: Molecules, medicines, and myths

Gutteridge, J. M. C., & Halliwell, B. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.071 · Cited by 405 · see citing works

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

Phillips, J. P., Campbell, S. D., Michaud, D., Charbonneau, M., & Hilliker, A. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2761 · Cited by 389 · see citing works

Aging: ROS or TOR

Blagosklonny, M. V. (2008) · Cell Cycle · doi:10.4161/cc.7.21.6965 · Cited by 375 · see citing works

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00449.x · Cited by 353 · see citing works

High oxidative damage levels in the longest‐living rodent, the naked mole‐rat

Andziak, B., O’Connor, T. P., Qi, W., deWaal, E., Pierce, A. P., Chaudhuri, A. R., Remmen, H. V., & Buffenstein, R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00237.x · Cited by 351 · see citing works

Evolutionary conservation of the <i>clk-1</i> -dependent mechanism of longevity: loss of <i>mclk1</i> increases cellular fitness and lifespan in mice

Liu, X., Jiang, N., Hughes, B., Bigras, E., Shoubridge, E., & Hekimi, S. (2005) · Genes &amp; Development · doi:10.1101/gad.1352905 · Cited by 345 · see citing works

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Cochemé, H. M., Quin, C., McQuaker, S. J., Cabreiro, F., Logan, A., Prime, T. A., Abakumova, I., Patel, J. V., Fearnley, I. M., James, A. M., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.003 · Cited by 313 · see citing works

Hydrogen Peroxide as a Cell-Survival Signaling Molecule

Groeger, G., Quiney, C., & Cotter, T. G. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2728 · Cited by 312 · see citing works

Hydrogen peroxide release by mitochondria increases during aging

Sohal, R. S., & Sohal, B. H. (1991) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(91)90034-w · Cited by 296 · see citing works

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H 2 O 2 and superoxide dismutase activity

Mesquita, A., Weinberger, M., Silva, A., Sampaio‐Marques, B., Almeida, B., Leão, C., Costa, V., Rodrigues, F. J. S., Burhans, W. C., & Ludovico, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004432107 · Cited by 268 · see citing works

Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms

Lambert, A. J., Boysen, H. M., Buckingham, J. A., Yang, T., Podlutsky, A. J., Austad, S. N., Kunz, T., Buffenstein, R., & Brand, M. D. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00312.x · Cited by 264 · see citing works

When a theory of aging ages badly

Lapointe, J., & Hekimi, S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0138-8 · Cited by 261 · see citing works

Age to survive: DNA damage and aging

Schumacher, B., Garinis, G. A., & Hoeijmakers, J. H. J. (2008) · Trends in Genetics · doi:10.1016/j.tig.2007.11.004 · Cited by 255 · see citing works

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

Yang, W., & Hekimi, S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00571.x · Cited by 251 · see citing works

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

Fukui, H., & Moraes, C. T. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.008 · Cited by 248 · see citing works

Tumor Necrosis Factor-α Generates Reactive Oxygen Species via a Cytosolic Phospholipase A2-linked Cascade

Woo, C.-H., Eom, Y. W., Yoo, M., You, H.-J., Han, H. J., Song, W. K., Yoo, Y. J., Chun, J.-S., & Kim, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005638200 · Cited by 234 · see citing works

Early Mitochondrial Dysfunction in Long-lived Mclk1+/- Mice

Lapointe, J., & Hekimi, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803287200 · Cited by 207 · see citing works

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

Zhang, Y., Ikeno, Y., Qi, W., Chaudhuri, A., Li, Y., Bokov, A., Thorpe, S. R., Baynes, J., Epstein, C. J., Richardson, A. G., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp132 · Cited by 206 · see citing works

[23] Ratio of reduced to oxidized glutathione as indicator of oxidative stress status and DNA damage

Asensi, M. A., Sastre, J., Pallardó, F. V., Lloret, A., Lehner, M., de la Asunción, J. G., & Viña, J. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)99026-2 · Cited by 193 · see citing works

Aging of myocardial collagen

de Souza, R. R. (2002) · Biogerontology · doi:10.1023/a:1021312027486 · Cited by 190 · see citing works

Protein Homeostasis in Models of Aging and Age-Related Conformational Disease

Kikis, E. A., Gidalevitz, T., & Morimoto, R. I. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7002-2_11 · Cited by 187 · see citing works

Reactive Oxygen Species and Aging in Caenorhabditis elegans : Causal or Casual Relationship?

Raamsdonk, J. M. V., & Hekimi, S. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3215 · Cited by 184 · see citing works

The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms

Buffenstein, R., Edrey, Y. H., Yang, T., & Mele, J. (2008) · AGE · doi:10.1007/s11357-008-9058-z · Cited by 182 · see citing works

A Measurable Increase in Oxidative Damage Due to Reduction in Superoxide Detoxification Fails to Shorten the Life Span of Long-Lived Mitochondrial Mutants of Caenorhabditis elegans

Yang, W., Li, J., & Hekimi, S. (2007) · Genetics · doi:10.1534/genetics.107.080788 · Cited by 171 · see citing works

A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

Duttaroy, A., Paul, A., Kundu, M., & Belton, A. (2003) · Genetics · doi:10.1093/genetics/165.4.2295 · Cited by 153 · see citing works

Oxidized Mitochondrial Protein Degradation and Repair in Aging and Oxidative Stress

Ugarte, N., Petropoulos, I., & Friguet, B. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2998 · Cited by 136 · see citing works

Ubiquinone Is Necessary for Mouse Embryonic Development but Is Not Essential for Mitochondrial Respiration

Levavasseur, F., Miyadera, H., Sirois, J., Tremblay, M. L., Kita, K., Shoubridge, E. A., & Hekimi, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108980200 · Cited by 127 · see citing works

Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1α in Long-Lived <i>Mclk1</i> +/− Mouse Mutants

Wang, D., Malo, D., & Hekimi, S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902352 · Cited by 123 · see citing works

Disparate patterns of age‐related changes in lipid peroxidation in long‐lived naked mole‐rats and shorter‐lived mice

Andziak, B., & Buffenstein, R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00246.x · Cited by 121 · see citing works

Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice

Huang, T., Carlson, E. J., Kozy, H. M., Mantha, S., Goodman, S. I., Ursell, P. C., & Epstein, C. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00694-3 · Cited by 114 · see citing works

Epithelial Cell Death Is an Important Contributor to Oxidant-mediated Acute Lung Injury

Budinger, G. R. S., Mutlu, G. M., Urich, D., Soberanes, S., Buccellato, L. J., Hawkins, K. A., Chiarella, S. E., Radigan, K. A., Eisenbart, J. D., Agrawal, H., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201002-0181oc · Cited by 114 · see citing works

Comparison of endothelial function, O2−· and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice

Labinskyy, N., Csiszár, A., Orosz, Z. Z., Smith, K. E., Rivera, A., Buffenstein, R., & Ungvari, Z. I. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00534.2006 · Cited by 102 · see citing works

Role of 4-hydroxynonenal and its metabolites in signaling

Dwivedi, S., Sharma, A., Patrick, B., Sharma, R., & Awasthi, S. (2007) · Redox Report · doi:10.1179/135100007x162211 · Cited by 99 · see citing works

Reactive oxygen species generated by renal ischemia and reperfusion trigger protection against subsequent renal ischemia and reperfusion injury in mice

Kim, J., Jang, H., & Park, K. M. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00474.2009 · Cited by 98 · see citing works

Changing Paradigms in Thiology

Flohé, L. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)73001-9 · Cited by 96 · see citing works

Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span

Sun, J., Molitor, J., & Tower, J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.01.009 · Cited by 93 · see citing works

Reversal of the Mitochondrial Phenotype and Slow Development of Oxidative Biomarkers of Aging in Long-lived Mclk1+/− Mice

Lapointe, J., Stepanyan, Z., Bigras, E., & Hekimi, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.006569 · Cited by 91 · see citing works

The Free Radical Fantasy

Howes, R. M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.004 · Cited by 88 · see citing works

Natural aging, expression of fibrosis-related genes and collagen deposition in rat lung

Calabresi, C., Arosio, B., Galimberti, L., Scanziani, E., Bergottini, R., Annoni, G., & Vergani, C. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.016 · Cited by 80 · see citing works

Acetate metabolism and aging: An emerging connection

Shimazu, T., Hirschey, M. D., Huang, J.-Y., Ho, L., & Verdin, E. M. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.05.001 · Cited by 79 · see citing works

Age-Dependent Expression of Fibrosis-Related Genes and Collagen Deposition in Rat Kidney Cortex

Gagliano, N., Arosio, B., Santambrogio, D., Balestrieri, M. R., Padoani, G., Tagliabue, J., Masson, S., Vergani, C., & Annoni, G. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.8.b365 · Cited by 71 · see citing works

The Role of Mitochondria in Drosophila Aging

Cho, J., Hur, J. H., & Walker, D. W. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.010 · Cited by 67 · see citing works

Disruption of the mGsta4 Gene Increases Life Span of C57BL Mice

Singh, S., Niemczyk, M., Saini, D., Sadovov, V., Zimniak, L., & Zimniak, P. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp165 · Cited by 56 · see citing works

Mitochondrial oxidative stress and mammalian healthspan

Wanagat, J., Dai, D., & Rabinovitch, P. S. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.06.002 · Cited by 52 · see citing works

Oxidative Damage in Mitochondrial DNA Is Not Extensive

Lim, K. S., Jeyaseelan, K., Whiteman, M., Jenner, A. M., & Halliwell, B. B. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.023 · Cited by 49 · see citing works

Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster

Mockett, R. J., Sohal, B. H., & Sohal, R. S. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.029 · Cited by 48 · see citing works

A bad boy comes good

Theopold, U. (2009) · Nature · doi:10.1038/461486a · Cited by 25 · see citing works

Reactive oxygen species contribute to the induction of superoxide dismutase during heat shock in cultured rat neonatal cardiomyocytes.

Wang, S., Zhu, H., & Chen, C. (2000) · PubMed · Cited by 9 · see citing works

Reactive oxygen species contribute to the induction of superoxide dismutase during heat shock in cultured rat neonatal cardiomyocytes

王胜, 朱洪生, & 陈长志 (2000) · 中华医学杂志：英文版 · Cited by 4 · see citing works

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931 · see citing works

ROS Are Good

Mittler, R. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2016.08.002 · Cited by 3,499 · see citing works

Physiological Roles of Mitochondrial Reactive Oxygen Species

Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632 · see citing works

The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology

Graves, D. B. (2012) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/45/26/263001 · Cited by 1,512 · see citing works

Mitochondrial ROS Signaling in Organismal Homeostasis

Shadel, G. S., & Horvath, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.10.001 · Cited by 1,353 · see citing works

Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0227-y · Cited by 1,272 · see citing works

Reactive oxygen species: from health to disease

Brieger, K., Schiavone, S., Miller Jr., F. J., & Krause, K.-H. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13659 · Cited by 1,133 · see citing works

The role of mitochondria in aging

Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087 · see citing works

Free radicals and antioxidants: updating a personal view

Halliwell, B. B. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00476.x · Cited by 918 · see citing works

Aging and age‐related diseases: from mechanisms to therapeutic strategies

Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021) · Biogerontology · doi:10.1007/s10522-021-09910-5 · Cited by 668 · see citing works

Ageing, age-related diseases and oxidative stress: What to do next?

Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100982 · Cited by 581 · see citing works

Mitochondria as signaling organelles

Chandel, N. S. (2014) · BMC Biology · doi:10.1186/1741-7007-12-34 · Cited by 576 · see citing works

Mitochondria as playmakers of apoptosis, autophagy and senescence

Abate, M., Festa, A., Falco, M., Lombardi, A., Luce, A., Grimaldi, A., Zappavigna, S., Sperlongano, P., Irace, C., Caraglia, M., et al. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.022 · Cited by 543 · see citing works

Role of mitochondrial reverse electron transport in ros signaling: Potential roles in health and disease

Scialò, F., Fernández-Ayala, D. J., & Sanz, A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00428 · Cited by 517 · see citing works

Molecular and physiological manifestations and measurement of aging in humans

Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530 · see citing works

Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies

Shields, H. J., Traa, A., & Van Raamsdonk, J. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628157 · Cited by 478 · see citing works

ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

de Almeida, A. J. P. O., de Oliveira, J. C. P. L., Pontes, L. V. D. S., Júnior, J. F. D. S., Gonçalves, T. A. F., Dantas, S. H., Feitosa, M. S. D. A., Silva, A. O., & de Medeiros, I. A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1225578 · Cited by 521 · see citing works

Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

Bernardi, P., Gerle, C., Halestrap, A. P., Jonas, E. A., Karch, J. M., Mnatsakanyan, N., Pavlov, E. V., Sheu, S., & Soukas, A. A. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01187-0 · Cited by 482 · see citing works

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi, C., Marchi, S., Simões, I. C. M., Ren, Z., Morciano, G., Perrone, M., Patalas‐Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., et al. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 467 · see citing works

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14023834 · Cited by 457 · see citing works

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

Nissanka, N., & Moraes, C. T. (2017) · FEBS Letters · doi:10.1002/1873-3468.12956 · Cited by 453 · see citing works

The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress

Koskenkorva-Frank, T. S., Weiss, G., Koppenol, W. H., & Burckhardt, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.001 · Cited by 406 · see citing works

Axis of ageing: telomeres, p53 and mitochondria

Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 380 · see citing works

Reactive Oxygen Species: the Dual Role in Physiological and Pathological Conditions of the Human Body

Bardaweel, S. K., Gül, M., Alzweiri, M., Ishaqat, A., ALSalamat, H., & Bashatwah, R. M. (2018) · Eurasian Journal of Medicine · doi:10.5152/eurasianjmed.2018.17397 · Cited by 376 · see citing works

The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans

Yee, C., Yang, W., & Hekimi, S. (2014) · Cell · doi:10.1016/j.cell.2014.02.055 · Cited by 356 · see citing works

Accelerated ageing of the lung in COPD: new concepts

Mercado, N., Ito, K., & Barnes, P. J. (2015) · Thorax · doi:10.1136/thoraxjnl-2014-206084 · Cited by 340 · see citing works

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

Tai, H., Wang, Z., Gong, H., Han, X., Zhou, J., Wang, X., Wei, X., Ding, Y., Huang, N., Qin, J., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1247143 · Cited by 334 · see citing works

Superoxide dismutase is dispensable for normal animal lifespan

Raamsdonk, J. M. V., & Hekimi, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116158109 · Cited by 334 · see citing works

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

Chandel, N. S., Jasper, H., Ho, T. T., & Passegué, E. (2016) · Nature Cell Biology · doi:10.1038/ncb3385 · Cited by 326 · see citing works

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

Baker, B. M., Nargund, A. M., Sun, T., & Haynes, C. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002760 · Cited by 326 · see citing works

The antioxidant paradox: less paradoxical now?

Halliwell, B. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04272.x · Cited by 318 · see citing works

Molecular and biological hallmarks of ageing

Aunan, J. R., Watson, M. M., Hagland, H. R., & Søreide, K. (2016) · British journal of surgery · doi:10.1002/bjs.10053 · Cited by 322 · see citing works

Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

Wang, C., Wu, S., Wu, Y., & Wei, Y. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213493069 · Cited by 315 · see citing works

Effects of aging on the male reproductive system

Gunes, S. O., Hekim, N., Arslan, M. A., & Aşçı, R. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0663-y · Cited by 306 · see citing works

Frailty and Protein-Energy Wasting in Elderly Patients with End Stage Kidney Disease

Kim, J. C., Kalantar‐Zadeh, K., & Kopple, J. D. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012010047 · Cited by 302 · see citing works

Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases

Lagoumtzi, S. M., & Chondrogianni, N. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.003 · Cited by 279 · see citing works

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

Polonikov, A. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00288 · Cited by 275 · see citing works

The role of mitochondrial DNA mutations and free radicals in disease and ageing

Lagouge, M., & Larsson, N. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12055 · Cited by 270 · see citing works

Senescence in COPD and Its Comorbidities

Barnes, P. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034314 · Cited by 267 · see citing works

Hallmarks of Aging: An Autophagic Perspective

Barbosa, M. C., Grosso, R. A., & Fader, C. M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00790 · Cited by 265 · see citing works

Toxicological and pharmacological concerns on oxidative stress and related diseases

Saeidnia, S., & Abdollahi, M. R. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.09.031 · Cited by 257 · see citing works

Mitochondrial redox signalling at a glance

Collins, Y., Chouchani, E. T., James, A. M., Menger, K. E., Cochemé, H. M., & Murphy, M. P. (2012) · Journal of Cell Science · doi:10.1242/jcs.098475 · Cited by 255 · see citing works

Antioxidants: Positive or Negative Actors?

Salehi, B., Martorell, M., Arbiser, J. L., Sureda, A., Martins, N. A., Maurya, P. K., Sharifi‐Rad, M., Kumar, P., & Sharifi‐Rad, J. (2018) · Biomolecules · doi:10.3390/biom8040124 · Cited by 259 · see citing works

Aging Hallmarks: The Benefits of Physical Exercise

Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246 · see citing works

Mitochondrial dysfunction and longevity in animals: Untangling the knot

Wang, Y., & Hekimi, S. (2015) · Science · doi:10.1126/science.aac4357 · Cited by 248 · see citing works

Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging

Lapenna, D. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102066 · Cited by 239 · see citing works

A complex systems approach to aging biology

Cohen, A. A., Ferrucci, L., Fülöp, T., Gravel, D., Hao, N., Kriete, A., Levine, M. E., Lipsitz, L. A., Olde Rikkert, M. G. M., Rutenberg, A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00252-6 · Cited by 221 · see citing works

Redox interplay between mitochondria and peroxisomes

Lismont, C., Nordgren, M., Van Veldhoven, P. P., & Fransen, M. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00035 · Cited by 214 · see citing works

C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair

Xu, S., & Chisholm, A. D. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.08.002 · Cited by 211 · see citing works

The Free Radical Theory of Aging Revisited: The Cell Signaling Disruption Theory of Aging

Viña, J., Borrás, C., Abdelaziz, K. M., Garcia-Valles, R., & Gómez‐Cabrera, M. C. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5111 · Cited by 215 · see citing works

Peroxisomal metabolism and oxidative stress

Nordgren, M., & Fransen, M. (2013) · Biochimie · doi:10.1016/j.biochi.2013.07.026 · Cited by 201 · see citing works

Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection

Sas, K., Szabó, E., & Vécsei, L. (2018) · Molecules · doi:10.3390/molecules23010191 · Cited by 199 · see citing works

Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century

Saeidnia, S., & Abdollahi, M. R. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.004 · Cited by 190 · see citing works

Ageing and the border between health and disease

MacNee, W., Rabinovich, R., & Choudhury, G. (2014) · European Respiratory Journal · doi:10.1183/09031936.00134014 · Cited by 188 · see citing works

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans

Hwang, A. B., Ryu, E.-A., Artan, M., Chang, H., Kabir, M. H., Nam, H.-J., Lee, D.-Y., Yang, J., Kim, S., Mair, W. B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411199111 · Cited by 189 · see citing works

Mechanisms linking mtDNA damage and aging

Pinto, M., & Moraes, C. T. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.005 · Cited by 179 · see citing works

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

DeBalsi, K. L., Hoff, K. E., & Copeland, W. C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.006 · Cited by 180 · see citing works

Measuring Biological Age via Metabonomics: The Metabolic Age Score

Hertel, J., Friedrich, N., Wittfeld, K., Pietzner, M., Budde, K., Van der Auwera, S., Lohmann, T., Teumer, A., Völzke, H., Nauck, M., et al. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00561 · Cited by 181 · see citing works

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results

Mut‐Salud, N., Alvarez, P. J., Garrido, J. M., Carrasco, E., Aránega, A., & Rodríguez‐Serrano, F. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6719534 · Cited by 180 · see citing works

Caloric restriction and the aging process: a critique

Sohal, R. S., & Forster, M. J. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.015 · Cited by 178 · see citing works

Anti-Inflammatory Lactobacillus rhamnosus CNCM I-3690 Strain Protects against Oxidative Stress and Increases Lifespan in Caenorhabditis elegans

Grompone, G., Martorell, P., Llopis, S., González, N., Genovés, S., Mulet, A. P., Fernández-Calero, T., Tiscornia, I. S., Bollati‐Fogolín, M., Chambaud, I., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052493 · Cited by 176 · see citing works

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.007 · Cited by 155 · see citing works

Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction

Smits, M. A. J., Schomakers, B. V., van Weeghel, M., Wever, E. J. M., Wüst, R. C. I., Dijk, F., Janssens, G. E., Goddijn, M., Mastenbroek, S., Houtkooper, R. H., et al. (2023) · Human Reproduction · doi:10.1093/humrep/dead177 · Cited by 169 · see citing works

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

Ramis, M. R., Esteban, S., Miralles, A., Tan, D., & Reiter, R. J. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.008 · Cited by 164 · see citing works

Signaling networks determining life span

Riera, C. E., Merkwirth, C., De Magalhaes Filho, C. D., & Dillin, A. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014451 · Cited by 161 · see citing works

Is Chronic Obstructive Pulmonary Disease an Accelerated Aging Disease?

MacNee, W. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-124aw · Cited by 149 · see citing works

The B55α Subunit of PP2A Drives a p53-Dependent Metabolic Adaptation to Glutamine Deprivation

Reid, M. A., Wang, W.-I., Rosales, K. R., Welliver, M. X., Pan, M., & Kong, M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.02.008 · Cited by 154 · see citing works

Mitochondrial Dysfunction and Ovarian Aging

Kasapoğlu, I., & Seli, E. U. (2020) · Endocrinology · doi:10.1210/endocr/bqaa001 · Cited by 156 · see citing works

NADPH—The Forgotten Reducing EquivalentPreprint

Chandel, N. S. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040550 · Cited by 156 · see citing works

Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace

Hecker, L. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00275.2017 · Cited by 153 · see citing works

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

Menéndez, J. A., Joven, J., Aragonès, G., Barrajón‐Catalán, E., Beltrán‐Debón, R., Borrás‐Linares, I., Camps, J., Corominas-Faja, B., Cufí, S., Fernández‐Arroyo, S., et al. (2013) · Cell Cycle · doi:10.4161/cc.23756 · Cited by 150 · see citing works

The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases

Nixon, R. A. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140443 · Cited by 149 · see citing works

Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells

Lee, J., Baek, K., Soetandyo, N., & Ye, Y. (2013) · Nature Communications · doi:10.1038/ncomms2532 · Cited by 147 · see citing works

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

Lucanic, M., Plummer, W. T., Chen, E., Harke, J., Foulger, A., Onken, B., Coleman-Hulbert, A. L., Dumas, K. J., Guo, S., Johnson, E., et al. (2017) · Nature Communications · doi:10.1038/ncomms14256 · Cited by 134 · see citing works

Mechanism of Inflammation in Age-Related Macular Degeneration

Parmeggiani, F., Romano, M., Costagliola, C., Semeraro, F., Incorvaia, C., D’Angelo, S., Perri, P., Palma, P. D., Nadai, K. D., & Sebastiani, A. (2012) · Mediators of Inflammation · doi:10.1155/2012/546786 · Cited by 135 · see citing works

Versatile Ti3C2Tx MXene for free-radical scavenging

Liu, J., Lü, W., Lu, X., Zhang, L., Dong, H., & Li, Y. (2021) · Nano Research · doi:10.1007/s12274-021-3751-y · Cited by 132 · see citing works

Adaptive Capacity to Bacterial Diet Modulates Aging in C. elegans

Pang, S., & Curran, S. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.005 · Cited by 132 · see citing works

Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways

Dues, D. J., Andrews, E. K., Schaar, C. E., Bergsma, A. L., Senchuk, M. M., & Raamsdonk, J. M. V. (2016) · Aging · doi:10.18632/aging.100939 · Cited by 131 · see citing works

Mediterranean diet and the hallmarks of ageing

Shannon, O. M., Ashor, A. W., Scialò, F., Saretzki, G. C., Martin-Ruiz, C. M., Lara, J., Matu, J., Griffiths, A., Robinson, N., Lionetti, L., et al. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00841-x · Cited by 131 · see citing works

Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice

Tian, G., Sawashita, J., Kubo, H., Nishio, S.-Y., Hashimoto, S., Suzuki, N., Yoshimura, H., Tsuruoka, M., Wang, Y., Liu, Y., et al. (2014) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2013.5406 · Cited by 123 · see citing works

CoQ10 and Aging

de Barcelos, I. P., & Haas, R. (2019) · Biology · doi:10.3390/biology8020028 · Cited by 126 · see citing works

Dietary antioxidant intake decreases carotid intima media thickness in women but not in men: A cross‐sectional assessment in the Kardiovize study

Maugeri, A., Hrušková, J., Jakubik, J., Kunzová, Š., Sochor, O., Barchitta, M., Agodi, A., Bauerová, H., Medina-Inojosa, J., & Vinciguerra, M. (2019) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2018.12.018 · Cited by 116 · see citing works

Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

Wang, Y., Oxer, D., & Hekimi, S. (2015) · Nature Communications · doi:10.1038/ncomms7393 · Cited by 120 · see citing works

Mitophagy in neurodegeneration and aging

Palikaras, K., & Tavernarakis, N. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00297 · Cited by 122 · see citing works

Innate Immunity in C. elegans

Engelmann, I., & Pujol, N. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8059-5_6 · Cited by 121 · see citing works

Thyroid Hormone Signaling and Homeostasis During Aging

Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117 · see citing works

Aging: Molecular Pathways and Implications on the Cardiovascular System

de Almeida, A. J. P. O., Ribeiro, T. P., & de Medeiros, I. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7941563 · Cited by 117 · see citing works

Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis

Matai, L., Sarkar, G. C., Chamoli, M., Malik, Y., Kumar, R., Rautela, U., Jana, N. R., Chakraborty, K., & Mukhopadhyay, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900055116 · Cited by 120 · see citing works

Revisiting the Hallmarks of Aging to Identify Markers of Biological Age

Guerville, F., Barreto, P. D. S., Ader, I., Andrieu, S., Casteilla, L., Dray, C., Fazilleau, N., Guyonnet, S., Langin, D., Liblau, R., et al. (2020) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2019.50 · Cited by 120 · see citing works

Chronic low‐grade inflammation in heart failure with preserved ejection fraction

Mesquita, T., Lin, Y., & Ibrahim, A. G.-E. (2021) · Aging Cell · doi:10.1111/acel.13453 · Cited by 117 · see citing works

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells

Goldberg, A. A., Beach, A., Davies, G. F., Harkness, T. A. A., LeBlanc, A. C., & Titorenko, V. I. (2011) · Oncotarget · doi:10.18632/oncotarget.338 · Cited by 112 · see citing works

Sex-related differences in oxidative stress and neurodegeneration

Tenkorang, M. A. A., Snyder, B., & Cunningham, R. L. (2017) · Steroids · doi:10.1016/j.steroids.2017.12.010 · Cited by 116 · see citing works

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis

Wang, H., Wang, N., Xu, D., Ma, Q., Chen, Y., Xu, S., Qin, X., Zhang, Y., Prehn, J. H. M., Wang, G., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1704104 · Cited by 112 · see citing works

Hsp90 inhibitors and drug resistance in cancer: The potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs

Lu, X., Xiao, L., Wang, L., & Ruden, D. M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.11.011 · Cited by 113 · see citing works

Oxidative Stress, Mitochondrial Dysfunction and the Mitochondria Theory of Aging

Kong, Y., Trabucco, S. E., & Zhang, H. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000358901 · Cited by 112 · see citing works

Biochemical Basis Underlying Sestrins’ Physiological Activities

Ho, A., Cho, C., Namkoong, S., Cho, U., & Lee, J.-H. (2016) · TIBS -Trends in Biochemical Sciences. Regular ed · doi:10.1016/j.tibs.2016.04.005 · Cited by 110 · see citing works

The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders

Fang, C., Gu, L., Smerin, D., Mao, S., & Xiong, X. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8495160 · Cited by 110 · see citing works

Functional Consequences of Age-Dependent Changes in Glutathione Status in the Brain

Currais, A. J. M., & Maher, P. A. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4996 · Cited by 104 · see citing works

Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control

Chen, L., Zhang, Y., Zhang, Q., Li, H., Luo, Z., Fang, H., Kim, S. H., Qin, L., Yotnda, P., Xu, J., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.002 · Cited by 104 · see citing works

A midlife crisis for the mitochondrial free radical theory of aging

Stuart, J. A., Maddalena, L. A., Merilovich, M., & Robb, E. L. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-4 · Cited by 84 · see citing works

When a theory of aging ages badly

Lapointe, J., & Hekimi, S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0138-8 · Cited by 261 · see citing works

Mitochondrial free radical theory of aging: Who moved my premise?: MFRTA: Who moved my premise?

Liu, Y., Long, J., & Liu, J. (2014) · Geriatrics &amp; Gerontology International · doi:10.1111/ggi.12296 · Cited by 27 · see citing works

doi:10.1155/2012/646354 Review Article

Stress, O., Dysfunction, M., Cui, H., Kong, Y., & Zhang, H. (2011)

The role of mitochondrial DNA mutations and free radicals in disease and ageing

Lagouge, M., & Larsson, N. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12055 · Cited by 270 · see citing works