The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
G-quadruplexes: the beginning and end of UTRs
Open accessAbstract
Molecular mechanisms that regulate gene expression can occur either before or after transcription. The information for post-transcriptional regulation can lie within the sequence or structure of the RNA transcript and it has been proposed that G-quadruplex nucleic acid sequence motifs may regulate translation as well as transcription. Here, we have explored the incidence of G-quadruplex motifs in and around the untranslated regions (UTRs) of mRNA. We observed a significant strand asymmetry, consistent with a general depletion of G-quadruplex-forming RNA. We also observed a positional bias in two distinct regions, each suggestive of a specific function. We observed an excess of G-quadruplex motifs towards the 5'-ends of 5'-UTRs, supportive of a hypothesis linking 5'-UTR RNA G-quadruplexes to translational control. We then analysed the vicinity of 3'-UTRs and observed an over-representation of G-quadruplex motifs immediately after the 3'-end of genes, especially in those cases where another gene is in close proximity, suggesting that G-quadruplexes may be involved in the termination of gene transcription.
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
Kumari, S., Bugaut, A., Huppert, J. L., & Balasubramanian, S. (2007) · Nature Chemical Biology · doi:10.1038/nchembio864 · Cited by 822
Self-citationControl of mammalian translation by mRNA structure near caps
Babendure, J. R., Babendure, J. L., Ding, J.-H., & Tsien, R. Y. (2006) · RNA · doi:10.1261/rna.2309906 · Cited by 339
Cited by
DNA secondary structures: stability and function of G-quadruplex structures
Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,446
The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA
Dominissini, D., Nachtergaele, S., Moshitch-Moshkovitz, S., Peer, E., Kol, N., Ben-Haim, M. S., Dai, Q., Di Segni, A., Salmon-Divon, M., Clark, W. C., et al. (2016) · Nature · doi:10.1038/nature16998 · Cited by 1,021
Skourti-Stathaki, K., Proudfoot, N. J., & Gromak, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.026 · Cited by 819
Re-evaluation of G-quadruplex propensity with G4Hunter
Bedrat, A., Lacroix, L., & Mergny, J.-L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw006 · Cited by 687
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
Wolfe, A. L., Singh, K., Zhong, Y., Drewe, P., Rajasekhar, V. K., Sanghvi, V. R., Mavrakis, K. J., Jiang, M., Roderick, J. E., Van der Meulen, J., et al. (2014) · Nature · doi:10.1038/nature13485 · Cited by 635
Metadata
- Authors
- Huppert, J. L., Bugaut, A., Kumari, S., & Balasubramanian, S.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-02
- Volume
- 36
- Issue
- 19
- Pages
- 6260-6268
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2130652515
- Cited by
- 429
- References
- 3
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- gold
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