The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Molecular mechanisms of eukaryotic pre-mRNA 3′ end processing regulation
Open accessAbstract
Messenger RNA (mRNA) 3' end formation is a nuclear process through which all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a poly(A) tail. This process, which consists in the recognition of defined poly(A) signals of the pre-mRNAs by a large cleavage/polyadenylation machinery, plays a critical role in gene expression. Indeed, the poly(A) tail of a mature mRNA is essential for its functions, including stability, translocation to the cytoplasm and translation. In addition, this process serves as a bridge in the network connecting the different transcription, capping, splicing and export machineries. It also participates in the quantitative and qualitative regulation of gene expression in a variety of biological processes through the selection of single or alternative poly(A) signals in transcription units. A large number of protein factors associates with this machinery to regulate the efficiency and specificity of this process and to mediate its interaction with other nuclear events. Here, we review the eukaryotic 3' end processing machineries as well as the comprehensive set of regulatory factors and discuss the different molecular mechanisms of 3' end processing regulation by proposing several overlapping models of regulation.
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Cites
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BackgroundAn intron enhancer recognized by splicing factors activates polyadenylation.
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Analysis and design of RNA sequencing experiments for identifying isoform regulation
Katz, Y., Wang, E. T., Airoldi, E. M., & Burge, C. B. (2010) · Nature Methods · doi:10.1038/nmeth.1528 · Cited by 1,353
Mechanisms and Consequences of Alternative Polyadenylation
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U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
Kaida, D., Berg, M. G., Younis, I., Kasim, M., Singh, L. N., Wan, L., & Dreyfuss, G. (2010) · Nature · doi:10.1038/nature09479 · Cited by 638
Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression
Karn, J., & Stoltzfus, C. M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006916 · Cited by 437
Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq
Shepard, P. J., Choi, E.-A., Lu, J., Flanagan, L. A., Hertel, K. J., & Shi, Y. (2011) · RNA · doi:10.1261/rna.2581711 · Cited by 431
Metadata
- Authors
- Millevoi, S., & Vagner, S.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-30
- Volume
- 38
- Issue
- 9
- Pages
- 2757-2774
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2106774938
- Cited by
- 390
- References
- 6
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- gold
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