The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
PubChem: a public information system for analyzing bioactivities of small molecules
Open accessAbstract
PubChem (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological properties of small molecules hosted by the US National Institutes of Health (NIH). PubChem BioAssay database currently contains biological test results for more than 700 000 compounds. The goal of PubChem is to make this information easily accessible to biomedical researchers. In this work, we present a set of web servers to facilitate and optimize the utility of biological activity information within PubChem. These web-based services provide tools for rapid data retrieval, integration and comparison of biological screening results, exploratory structure-activity analysis, and target selectivity examination. This article reviews these bioactivity analysis tools and discusses their uses. Most of the tools described in this work can be directly accessed at http://pubchem.ncbi.nlm.nih.gov/assay/. URLs for accessing other tools described in this work are specified individually.
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Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
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PubChem Substance and Compound databases
Kim, S., Thiessen, P. A., Bolton, E. E., Chen, J., Fu, G., Gindulyte, A., Han, L., He, J., He, S., Shoemaker, B. A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv951 · Cited by 5,436
Self-citationEnumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17
Ruddigkeit, L., van Deursen, R., Blum, L. C., & Reymond, J.-L. (2012) · Journal of Chemical Information and Modeling · doi:10.1021/ci300415d · Cited by 1,505
Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment
Zhang, R., Zhu, X., Bai, H., & Ning, K. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00123 · Cited by 1,257
Geer, L. Y., Marchler-Bauer, A., Geer, R. C., Han, L., He, J., He, S., Liu, C., Shi, W., & Bryant, S. H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp858 · Cited by 875
Self-citationDatabase resources of the National Center for Biotechnology Information
Coordinators, N. R. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1189 · Cited by 854
Metadata
- Authors
- Wang, Y., Xiao, J., Suzek, T. O., Zhang, J., Wang, J., & Bryant, S. H.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06-04
- Volume
- 37
- Issue
- Web Server
- Pages
- W623-W633
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2127553917
- Cited by
- 1,467
- References
- 1
- FWCI
- 72.43
- Type
- journal article
- Language
- en
- Open access
- gold
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