The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea
Open accessAbstract
TADB (http://bioinfo-mml.sjtu.edu.cn/TADB/) is an integrated database that provides comprehensive information about Type 2 toxin-antitoxin (TA) loci, genetic features that are richly distributed throughout bacterial and archaeal genomes. Two-gene and much less frequently three-gene Type 2 TA loci code for cognate partners that have been hypothesized or demonstrated to play key roles in stress response, bacterial physiology and stabilization of horizontally acquired genetic elements. TADB offers a unique compilation of both predicted and experimentally supported Type 2 TA loci-relevant data and currently contains 10,753 Type 2 TA gene pairs identified within 1240 prokaryotic genomes, and details of over 240 directly relevant scientific publications. A broad range of similarity search, sequence alignment, genome context browser and phylogenetic tools are readily accessible via TADB. We propose that TADB will facilitate efficient, multi-disciplinary and innovative exploration of the bacteria and archaea Type 2 TA space, better defining presently recognized TA-related phenomena and potentially even leading to yet-to-be envisaged frontiers. The TADB database, envisaged as a one-stop shop for Type 2 TA-related research, will be maintained, updated and improved regularly to ensure its ongoing maximum utility to the research community.
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Cited by
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Jurėnas, D., Fraikin, N., Goormaghtigh, F., & Van Melderen, L. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00661-1 · Cited by 458
Regulation of growth and death in Escherichia coli by toxin–antitoxin systems
Yamaguchi, Y., & Inouye, M. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2651 · Cited by 383
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Metadata
- Authors
- Shao, Y., Harrison, E. M., Bi, D., Tai, C., He, X., Ou, H.-Y., Rajakumar, K., & Deng, Z.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-10-06
- Volume
- 39
- Issue
- suppl_1
- Pages
- D606-D611
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2045114886
- Cited by
- 254
- References
- 29
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shao, Y., Harrison, E. M., Bi, D., Tai, C., He, X., Ou, H.-Y., Rajakumar, K., & Deng, Z. (2011). TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea. Nucleic Acids Research. https://doi.org/10.1093/nar/gkq908
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