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Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

Sandler, Heike, Kreth, Jochen, Timmers, H. Th. Marc, Stoecklin, Georg·2011·Nucleic Acids Research
DOI 10.1093/nar/gkr011PMC PMC3105394
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  • The CCR4-NOT poly(A) deadenylase complex interacts with ZFP36 and ZFP36L1 and acts as an important effector complex of ZFP36-mediated mRNA-destabilization.

    “It is known to interact with ZFP36 and ZFP36L1 and to act as an important effector complex of ZFP36-mediated mRNA-destabilization (16,17).”

    From ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) · cites this paper as [17]

    The Results sections report that Not1, a scaffold of the CCR4–NOT complex, associates with tristetraprolin (TTP/ZFP36) and is required for TTP-mediated mRNA decay. The Introduction mentions related proteins BRF1 and BRF2, but our copy does not show an interaction between CCR4–NOT and ZFP36L1; that part of the claim is unsupported. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • MAPKAPK2, a downstream kinase of p38, phosphorylates ZFP36, but not in the C-terminal region, leading to dissociation of ZFP36 and CNOT7.

    “Recently, MAPKAPK2, a downstream kinase of p38, has been shown to phosphorylate ZFP36, but not in the C-terminal region, leading to dissociation of ZFP36 and CNOT7 (16,17).”

    From ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) · cites this paper as [17]

    The Discussion (page unavailable) says MK2 phosphorylates TTP/ZFP36 at S52 and S178 and that phosphorylation reduces its interaction with Caf1; the Introduction identifies Caf1a as CNOT7. Our copy does not establish that phosphorylation excludes the C-terminal region or identify MK2 as downstream of p38. It reports reduced interaction, not complete dissociation. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The CCR4-NOT deadenylase complex interacts with the C-terminus of ZFP36.

    “The CCR4-NOT deadenylase complex has recently been shown to interact with the C-terminus of ZFP36 (16,17); therefore, we next examined whether ZFP36L1 interacts with the CCR4-NOT deadenylase complex and whether this interaction is affected by PMA.”

    From ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) · cites this paper as [17]

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Research works printed but not linked: 57

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Metadata

Authors
Sandler, H., Kreth, J., Timmers, H. T. M., & Stoecklin, G.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2011-01-29
Volume
39
Issue
10
Pages
4373-4386
ISSN
  • 1362-4962
  • 0305-1048
DOI
10.1093/nar/gkr011
PMC
PMC3105394
Cited by
221
References
0
Language
en
Licence
creativecommons.org/licenses/by-nc/2.5 (vor, 2075 d)

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