The highways and byways of mRNA decay
Abstract
When considering the control of gene expression, the focus has traditionally been on transcriptional regulation. Recently, however, the large contribution made by mRNA decay has become difficult to ignore. Large-scale analyses indicate that as many as half of all changes in the amounts of mRNA in some responses can be attributed to altered rates of decay. In this article, we discuss some of the mechanisms that are used by the cell to mediate and regulate this intriguing process.
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mRNA therapeutics require optimization of mRNA sequences because their effectiveness primarily depends on the rate of degradation and the rate of translation initiation.
“Nevertheless, mRNA therapeutics require the optimization of mRNA sequences because their effectiveness primarily depends on the rate of degradation (and the rate of translation initiation) of mRNA [1,2].”
From Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis (2024) · cites this paper as [1]
3′UTR AU-rich elements can determine the rate of mRNA decay under various conditions.
“3′UTR AU-rich elements can determine the rate of mRNA decay under various conditions [1,8].”
From Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis (2024) · cites this paper as [1]
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- Authors
- Garneau, N. L., Wilusz, J., & Wilusz, C. J.
- Affiliations
- Colorado State University (US)
- Corresponding author
- Wilusz, Carol J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-02
- Volume
- 8
- Issue
- 2
- Pages
- 113-126
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2088860412
- Cited by
- 1,294
- References
- 0
- Citations by year
- 2026: 33 · 2025: 54 · 2024: 55 · 2023: 58 · 2022: 62 · 2021: 52 · 2020: 61 · 2019: 67 · 2018: 57 · 2017: 43 · 2016: 74 · 2015: 75 · 2014: 75 · 2013: 81 · 2012: 93
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- mRNA degradation, mRNA turnover, gene expression regulation, post-transcriptional regulation, signal transduction, mRNA metabolism
- MeSH terms
- Cell Line, Gene Expression Regulation, Humans, Models, Genetic, RNA, Messenger, Transcription, Genetic, Signal Transduction, RNA Stability
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