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MODOMICS: a database of RNA modification pathways—2013 update

Open access
Machnicka, Magdalena A., Milanowska, Kaja, Osman Oglou, Okan, Purta, Elzbieta, Kurkowska, Malgorzata, Olchowik, Anna, Januszewski, Witold, Kalinowski, Sebastian, Dunin-Horkawicz, Stanislaw, Rother, Kristian M., Helm, Mark, Bujnicki, Janusz M., Grosjean, Henri·2012·Nucleic Acids Research

Abstract

MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, RNA-modifying enzymes and location of modified residues in RNA sequences. In the current database version, accessible at http://modomics.genesilico.pl, we included new features: a census of human and yeast snoRNAs involved in RNA-guided RNA modification, a new section covering the 5'-end capping process, and a catalogue of 'building blocks' for chemical synthesis of a large variety of modified nucleosides. The MODOMICS collections of RNA modifications, RNA-modifying enzymes and modified RNAs have been also updated. A number of newly identified modified ribonucleosides and more than one hundred functionally and structurally characterized proteins from various organisms have been added. In the RNA sequences section, snRNAs and snoRNAs with experimentally mapped modified nucleosides have been added and the current collection of rRNA and tRNA sequences has been substantially enlarged. To facilitate literature searches, each record in MODOMICS has been cross-referenced to other databases and to selected key publications. New options for database searching and querying have been implemented, including a BLAST search of protein sequences and a PARALIGN search of the collected nucleic acid sequences.

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Metadata

Authors
Machnicka, M. A., Milanowska, K., Osman Oglou, O., Purta, E., Kurkowska, M., Olchowik, A., Januszewski, W., Kalinowski, S., Dunin-Horkawicz, S., Rother, K. M., Helm, M., Bujnicki, J. M., & Grosjean, H.
Venue
Nucleic Acids Research
Published
2012-10-30
Volume
41
Issue
D1
Pages
D262-D267
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W1982749428
Cited by
1,013
References
5
FWCI
25.56
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: MODOMICS: a database of RNA modification pathways—2013 update. https://app.cochat.ai/papers/10.1093/nar/gks1007
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Machnicka, M. A., Milanowska, K., Osman Oglou, O., Purta, E., Kurkowska, M., Olchowik, A., Januszewski, W., Kalinowski, S., Dunin-Horkawicz, S., Rother, K. M., Helm, M., Bujnicki, J. M., & Grosjean, H. (2012). MODOMICS: a database of RNA modification pathways—2013 update. Nucleic Acids Research. https://doi.org/10.1093/nar/gks1007

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