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MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis

Open access
Xia, J., Mandal, R., Sinelnikov, I. V., Broadhurst, D., Wishart, D. S.·2012·Nucleic Acids Research

Abstract

First released in 2009, MetaboAnalyst (www.metaboanalyst.ca) was a relatively simple web server designed to facilitate metabolomic data processing and statistical analysis. With continuing advances in metabolomics along with constant user feedback, it became clear that a substantial upgrade to the original server was necessary. MetaboAnalyst 2.0, which is the successor to MetaboAnalyst, represents just such an upgrade. MetaboAnalyst 2.0 now contains dozens of new features and functions including new procedures for data filtering, data editing and data normalization. It also supports multi-group data analysis, two-factor analysis as well as time-series data analysis. These new functions have also been supplemented with: (i) a quality-control module that allows users to evaluate their data quality before conducting any analysis, (ii) a functional enrichment analysis module that allows users to identify biologically meaningful patterns using metabolite set enrichment analysis and (iii) a metabolic pathway analysis module that allows users to perform pathway analysis and visualization for 15 different model organisms. In developing MetaboAnalyst 2.0 we have also substantially improved its graphical presentation tools. All images are now generated using anti-aliasing and are available over a range of resolutions, sizes and formats (PNG, TIFF, PDF, PostScript, or SVG). To improve its performance, MetaboAnalyst 2.0 is now hosted on a much more powerful server with substantially modified code to take advantage the server's multi-core CPUs for computationally intensive tasks. MetaboAnalyst 2.0 also maintains a collection of 50 or more FAQs and more than a dozen tutorials compiled from user queries and requests. A downloadable version of MetaboAnalyst 2.0, along detailed instructions for local installation is now available as well.

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Metadata

Authors
Xia, J., Mandal, R., Sinelnikov, I. V., Broadhurst, D., & Wishart, D. S.
Venue
Nucleic Acids Research
Published
2012-05-02
Volume
40
Issue
W1
Pages
W127-W133
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2135607659
Cited by
1,150
References
4
FWCI
49.84
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis. https://app.cochat.ai/papers/10.1093/nar/gks374
The paper
Xia, J., Mandal, R., Sinelnikov, I. V., Broadhurst, D., & Wishart, D. S. (2012). MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis. Nucleic Acids Research. https://doi.org/10.1093/nar/gks374

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