The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways
Open accessAbstract
MicroRNAs (miRNAs) are key regulators of diverse biological processes and their functional analysis has been deemed central in many research pipelines. The new version of DIANA-miRPath web server was redesigned from the ground-up. The user of DNA Intelligent Analysis (DIANA) DIANA-miRPath v2.0 can now utilize miRNA targets predicted with high accuracy based on DIANA-microT-CDS and/or experimentally verified targets from TarBase v6; combine results with merging and meta-analysis algorithms; perform hierarchical clustering of miRNAs and pathways based on their interaction levels; as well as elaborate sophisticated visualizations, such as dendrograms or miRNA versus pathway heat maps, from an intuitive and easy to use web interface. New modules enable DIANA-miRPath server to provide information regarding pathogenic single nucleotide polymorphisms (SNPs) in miRNA target sites (SNPs module) or to annotate all the predicted and experimentally validated miRNA targets in a selected molecular pathway (Reverse Search module). DIANA-miRPath v2.0 is an efficient and yet easy to use tool that can be incorporated successfully into miRNA-related analysis pipelines. It provides for the first time a series of highly specific tools for miRNA-targeted pathway analysis via a web interface and can be accessed at http://www.microrna.gr/miRPathv2.
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Cites
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“Information regarding the number of targets and the derived predictive accuracy for different thresholds, as calculated against experimentally verified miRNA targets (20) is provided in Supplementary Table S1.”
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Cited by
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Metadata
- Authors
- Vlachos, I. S., Kostoulas, N., Vergoulis, T., Georgakilas, G., Reczko, M., Maragkakis, M., Paraskevopoulou, M. D., Prionidis, K., Dalamagas, T., & Hatzigeorgiou, A. G.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05-30
- Volume
- 40
- Issue
- W1
- Pages
- W498-W504
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2081113032
- Cited by
- 526
- References
- 31
- FWCI
- 17.34
- Type
- journal article
- Language
- en
- Open access
- gold
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