Gene silencing by microRNAs: contributions of translational repression and mRNA decay

MicroRNAs: Target Recognition and Regulatory Functions

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Untitled work

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Origins and Mechanisms of miRNAs and siRNAs

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Mammalian microRNAs predominantly act to decrease target mRNA levels

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Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

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The impact of microRNAs on protein output

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Widespread changes in protein synthesis induced by microRNAs

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The mechanism of eukaryotic translation initiation and principles of its regulation

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Prediction of Plant MicroRNA Targets

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Origin, Biogenesis, and Activity of Plant MicroRNAs

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Regulation of Flowering Time and Floral Organ Identity by a MicroRNA and Its APETALA2 -Like Target Genes

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A MicroRNA as a Translational Repressor of APETALA2 in Arabidopsis Flower Development

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MicroRNA-Directed Cleavage of <i>HOXB8</i> mRNA

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The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

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Widespread translational inhibition by plant miRNAs and siRNAs

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Specific effects of microRNAs on the plant transcriptome

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Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

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Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

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Cleavage of <i>Scarecrow-like</i> mRNA Targets Directed by a Class of <i>Arabidopsis</i> miRNA

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Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

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MicroRNAs direct rapid deadenylation of mRNA

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Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

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Getting to the Root of miRNA-Mediated Gene Silencing

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesPreprint

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A biochemical framework for RNA silencing in plantsPreprint

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The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

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Global identification of microRNA–target RNA pairs by parallel analysis of RNA ends

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Endogenous siRNA and miRNA Targets Identified by Sequencing of the Arabidopsis Degradome

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Short RNAs Repress Translation after Initiation in Mammalian Cells

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A three-dimensional view of the molecular machinery of RNA interference

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A role for the P-body component GW182 in microRNA function

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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

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MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F

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The miRNA156/157 recognition element in the 3′ UTR of the Arabidopsis SBP box gene SPL3 prevents early flowering by translational inhibition in seedlings

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Identification of Novel Argonaute-Associated Proteins

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Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54

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Disruption of GW bodies impairs mammalian RNA interference

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A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

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Human let-7a miRNA blocks protein production on actively translating polyribosomes

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Deadenylation is a widespread effect of miRNA regulation

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Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA

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GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

Eulálio, A., Huntzinger, E., & Izaurralde, E. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1405 · Cited by 414 · see citing works

Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs

Wu, L., & Belasco, J. G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.010 · Cited by 409 · see citing works

Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation

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A Collection of Target Mimics for Comprehensive Analysis of MicroRNA Function in Arabidopsis thaliana

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Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

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AtXRN4 Degrades mRNA in Arabidopsis and Its Substrates Include Selected miRNA Targets

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Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

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Evidence that microRNAs are associated with translating messenger RNAs in human cells

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Biochemical Evidence for Translational Repression by Arabidopsis MicroRNAs

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Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free systemPreprint

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Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencingPreprint

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Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430

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The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans

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Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells

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Sucrose induction of Arabidopsis miR398 represses two Cu/Zn superoxide dismutases

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A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

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Systematic Identification of C. elegans miRISC Proteins, miRNAs, and mRNA Targets by Their Interactions with GW182 Proteins AIN-1 and AIN-2

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Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells

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The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

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Drosophila Argonaute1 and Argonaute2 Employ Distinct Mechanisms for Translational Repression

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The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release

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Recapitulation of Short RNA-Directed Translational Gene Silencing In Vitro

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The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

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The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

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CCR4-NOT Deadenylates mRNA Associated with RNA-Induced Silencing Complexes in Human Cells

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Genome-Wide Analysis of mRNAs Regulated by Drosha and Argonaute Proteins in Drosophila melanogaster

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Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression

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GW182 family proteins are crucial for microRNA-mediated gene silencing

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Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

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Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

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A C-terminal silencing domain in GW182 is essential for miRNA function

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Regulation of Poly(A)-binding Protein through PABP-interacting ProteinsPreprint

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Two PABPC1‐binding sites in GW182 proteins promote miRNA‐mediated gene silencing

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microRNA-Mediated Messenger RNA Deadenylation Contributes to Translational Repression in Mammalian Cells

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Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

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Structural Basis of Binding of P-body-associated Proteins GW182 and Ataxin-2 by the Mlle Domain of Poly(A)-binding Protein

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Pervasive and Cooperative Deadenylation of 3′UTRs by Embryonic MicroRNA Families

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Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

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Drosophila miR2 Primarily Targets the m7GpppN Cap Structure for Translational Repression

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Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila

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Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing

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Regulation of microRNA biogenesis

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Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

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Towards a molecular understanding of microRNA-mediated gene silencing

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DIANA-miRPath v3.0: deciphering microRNA function with experimental support

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MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

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Expanded identification and characterization of mammalian circular RNAs

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miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis

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Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

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DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions

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