The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
Open accessAbstract
Maintenance of genomic integrity is essential to ensure normal organismal development and to prevent diseases such as cancer. Nuclear DNA is packaged into chromatin, and thus genome maintenance can be influenced by distinct chromatin environments. In particular, post-translational modifications of histones have emerged as key regulators of genomic integrity. Intense research during the past few years has revealed histone H4 lysine 20 methylation (H4K20me) as critically important for the biological processes that ensure genome integrity, such as DNA damage repair, DNA replication and chromatin compaction. The distinct H4K20 methylation states are mediated by SET8/PR-Set7 that catalyses monomethylation of H4K20, whereas SUV4-20H1 and SUV4-20H2 enzymes mediate further H4K20 methylation to H4K20me2 and H4K20me3. Disruption of these H4K20-specific histone methyltransferases leads to genomic instability, demonstrating the important functions of H4K20 methylation in genome maintenance. In this review, we explain molecular mechanisms underlying these defects and discuss novel ideas for furthering our understanding of genome maintenance in higher eukaryotes.
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Cites
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Cited by
Writing, erasing and reading histone lysine methylations
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The roles of DNA, RNA and histone methylation in ageing and cancer
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Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
Biswas, S., & Rao, C. M. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.08.021 · Cited by 389
Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase
Lin, F., Zhang, R., Shao, W., Lei, C., Ma, M., Zhang, Y., Wen, Z., & Li, W. (2023) · Cell Discovery · doi:10.1038/s41421-023-00620-5 · Cited by 10
Metadata
- Authors
- Jorgensen, S., Schotta, G., & Sorensen, C. S.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-01-23
- Volume
- 41
- Issue
- 5
- Pages
- 2797-2806
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2118619702
- Cited by
- 396
- References
- 56
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- gold
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