The DOI matches its Crossref record; 239 of the 239 references it cites were found in a registry or an index.
Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
Abstract
Addition of chemical tags on the DNA and modification of histone proteins impart a distinct feature on chromatin architecture. With the advancement in scientific research, the key players underlying these changes have been identified as epigenetic modifiers of the chromatin. Indeed, the plethora of enzymes catalyzing these modifications, portray the diversity of epigenetic space and the intricacy in regulating gene expression. These epigenetic players are categorized as writers: that introduce various chemical modifications on DNA and histones, readers: the specialized domain containing proteins that identify and interpret those modifications and erasers: the dedicated group of enzymes proficient in removing these chemical tags. Research over the past few decades has established that these epigenetic tools are associated with numerous disease conditions especially cancer. Besides, with the involvement of epigenetics in cancer, these enzymes and protein domains provide new targets for cancer drug development. This is certain from the volume of epigenetic research conducted in universities and R&D sector of pharmaceutical industry. Here we have highlighted the different types of epigenetic enzymes and protein domains with an emphasis on methylation and acetylation. This review also deals with the recent developments in small molecule inhibitors as potential anti-cancer drugs targeting the epigenetic space.
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1 retracted
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Cited by
The timeline of epigenetic drug discovery: from reality to dreams
Ganesan, A., Arimondo, P. B., Rots, M. G., Jeronimo, C., & Berdasco, M. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0776-0 · Cited by 341
The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases
Todd, A. C., & Hardingham, G. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249607 · Cited by 172
Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg
Fernández-Barrena, M. G., Arechederra, M., Colyn, L., Berasain, C., & Avila, M. A. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100167 · Cited by 126
Epigenetic genes and epilepsy — emerging mechanisms and clinical applications
Van Loo, K. M. J., Carvill, G. L., Becker, A. J., Conboy, K., Goldman, A. M., Kobow, K., Lopes-Cendes, I., Reid, C. A., van Vliet, E. A., & Henshall, D. C. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00693-y · Cited by 68
Poziello, A., Nebbioso, A., Stunnenberg, H. G., Martens, J. H. A., Carafa, V., & Altucci, L. (2021) · Epigenetics · doi:10.1080/15592294.2020.1827723 · Cited by 44
Metadata
- Authors
- Biswas, S., & Rao, C. M.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 837
- Pages
- 8-24
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2887245558
- Cited by
- 389
- References
- 239
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Biswas, S., & Rao, C. M. (2018). Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy. European Journal of Pharmacology. https://doi.org/10.1016/j.ejphar.2018.08.021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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