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Cited by 905

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Low-level processing of Illumina Infinium DNA Methylation BeadArrays

Open access
Triche, Timothy J., Weisenberger, Daniel J., Van Den Berg, David, Laird, Peter W., Siegmund, Kimberly D.·2013·Nucleic Acids Research

Abstract

We propose a novel approach to background correction for Infinium HumanMethylation data to account for technical variation in background fluorescence signal. Our approach capitalizes on a new use for the Infinium I design bead types to measure non-specific fluorescence in the colour channel opposite of their design (Cy3/Cy5). This provides tens of thousands of features for measuring background instead of the much smaller number of negative control probes on the platforms (n = 32 for HumanMethylation27 and n = 614 for HumanMethylation450, respectively). We compare the performance of our methods with existing approaches, using technical replicates of both mixture samples and biological samples, and demonstrate that within- and between-platform artefacts can be substantially reduced, with concomitant improvement in sensitivity, by the proposed methods.

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Metadata

Authors
Triche, T. J., Weisenberger, D. J., Van Den Berg, D., Laird, P. W., & Siegmund, K. D.
Venue
Nucleic Acids Research
Published
2013-03-09
Volume
41
Issue
7
Pages
e90-e90
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2081182312
Cited by
905
References
7
FWCI
10.49
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Low-level processing of Illumina Infinium DNA Methylation BeadArrays. https://app.cochat.ai/papers/10.1093/nar/gkt090
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Triche, T. J., Weisenberger, D. J., Van Den Berg, D., Laird, P. W., & Siegmund, K. D. (2013). Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Research. https://doi.org/10.1093/nar/gkt090

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