The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening
Open accessAbstract
Guanine-rich RNA sequences can fold into non-canonical, four stranded helical structures called G-quadruplexes that have been shown to be widely distributed within the mammalian transcriptome, as well as being key regulatory elements in various biological mechanisms. That said, their role within the 3'-untranslated region (UTR) of mRNA remains to be elucidated and appreciated. A bioinformatic analysis of the 3'-UTRs of mRNAs revealed enrichment in G-quadruplexes. To shed light on the role(s) of these structures, those found in the LRP5 and FXR1 genes were characterized both in vitro and in cellulo. The 3'-UTR G-quadruplexes were found to increase the efficiencies of alternative polyadenylation sites, leading to the expression of shorter transcripts and to possess the ability to interfere with the miRNA regulatory network of a specific mRNA. Clearly, G-quadruplexes located in the 3'-UTRs of mRNAs are cis-regulatory elements that have a significant impact on gene expression.
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Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613
An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
Kumari, S., Bugaut, A., Huppert, J. L., & Balasubramanian, S. (2007) · Nature Chemical Biology · doi:10.1038/nchembio864 · Cited by 822
Mechanism and regulation of mRNA polyadenylation
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In-Line Probing Analysis of Riboswitches
Regulski, E. E., & Breaker, R. R. (2008) · Methods In Molecular Biology™ · doi:10.1007/978-1-59745-033-1_4 · Cited by 338
G-quadruplex RNA structure as a signal for neurite mRNA targeting
Subramanian, M., Rage, F., Tabet, R., Flatter, E., Mandel, J., & Moine, H. (2011) · The EMBO Reports · doi:10.1038/embor.2011.76 · Cited by 250 · cited 2×
“For example, it was recently reported that two dendritic mRNAs, PSD-95 and CaMKIIa, possessed 30UTR G4s with the ability to act as specific localization signals, targeting these RNAs to cortical neuritis (17).”
Background
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Moreno-Mateos, M. A., Vejnar, C. E., Beaudoin, J.-D., Fernandez, J. P., Mis, E. K., Khokha, M. K., & Giraldez, A. J. (2015) · Nature Methods · doi:10.1038/nmeth.3543 · Cited by 1,290
Self-citationReadhead, B., Haure-Mirande, J.-V., Funk, C. C., Richards, M. A., Shannon, P., Haroutunian, V., Sano, M., Liang, W. S., Beckmann, N. D., Price, N. D., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.023 · Cited by 708
rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome
Kwok, C. K., Marsico, G., Sahakyan, A. B., Chambers, V. S., & Balasubramanian, S. (2016) · Nature Methods · doi:10.1038/nmeth.3965 · Cited by 438
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Metadata
- Authors
- Beaudoin, J.-D., & Perreault, J.-P.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04-22
- Volume
- 41
- Issue
- 11
- Pages
- 5898-5911
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1964335041
- Cited by
- 167
- References
- 6
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- gold
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- Beaudoin, J.-D., & Perreault, J.-P. (2013). Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening. Nucleic Acids Research. https://doi.org/10.1093/nar/gkt265
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