Mechanism and regulation of mRNA polyadenylation
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The 3′ UTR harbors polyadenylation signals, which can generate multiple isoforms with distinct 3′ ends through alternative polyadenylation.
“The 3′ untranslated region (UTR) harbors regulatory regions called polyadenylation signals (PASs), which can generate multiple isoforms with distinct 3′ ends through alternative polyadenylation (APA)39–41.”
From Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation (2025) · cites this paper as [39]
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Ashe, M. P., Griffin, P., James, W., & Proudfoot, N. J. (1995) · Genes & Development · doi:10.1101/gad.9.23.3008 · Cited by 125 · see citing works
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Mechanisms of Alternative Pre-Messenger RNA Splicing
Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704 · see citing works
Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613 · see citing works
Mechanisms and Consequences of Alternative Polyadenylation
Di Giammartino, D. C., Nishida, K., & Manley, J. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.017 · Cited by 737 · see citing works
Self-citationTranscriptional and Posttranscriptional Regulation of HIV-1 Gene Expression
Karn, J., & Stoltzfus, C. M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006916 · Cited by 437 · see citing works
Cytoplasmic Polyadenylation in Development and Beyond
Richter, J. D. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.446-456.1999 · Cited by 299 · see citing works
Ji, Z., & Tian, B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008419 · Cited by 264 · see citing works
Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation
Linder, J., Srivastava, D., Yuan, H., Agarwal, V., & Kelley, D. R. (2025) · Nature Genetics · doi:10.1038/s41588-024-02053-6 · Cited by 265 · see citing works
The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site
Shi, Y., & Manley, J. L. (2015) · Genes & Development · doi:10.1101/gad.261974.115 · Cited by 249 · see citing works
Self-citationPre‐mRNA 3′‐end processing complex assembly and function
Chan, S., Choi, E., & Shi, Y. (2011) · WIREs RNA · doi:10.1002/wrna.54 · Cited by 147 · see citing works
A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing
Yu, S., & Kim, V. N. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0246-8 · Cited by 142 · see citing works
RNA polymerase II kinetics in polo polyadenylation signal selection
Pinto, P. A. B., Henriques, T., Freitas, M. O., Martins, T., Domingues, R. G., Wyrzykowska, P. S., Coelho, P. A., Carmo, A. M., Sunkel, C. E., Proudfoot, N. J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.156 · Cited by 136 · see citing works
Tamaddon, M., Shokri, G., Hosseini Rad, S. M. A., Rad, I., Emami Razavi, À., & Kouhkan, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-68406-3 · Cited by 25 · see citing works
- Authors
- Colgan, D. F., & Manley, J. L.
- Affiliations
- Columbia University (US)
- ORCID
- Manley, James L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1997-11-01
- Volume
- 11
- Issue
- 21
- Pages
- 2755-2766
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2151971476
- Cited by
- 784
- References
- 1
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 14 · 2023: 20 · 2022: 16 · 2021: 31 · 2020: 17 · 2019: 22 · 2018: 14 · 2017: 28 · 2016: 21 · 2015: 28 · 2014: 30 · 2013: 38 · 2012: 29
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- mRNA polyadenylation, poly(A) site selection, poly(A) polymerase, mRNA 3' end processing, post-transcriptional regulation, RNA polymerase II
- MeSH terms
- Animals, Base Sequence, Humans, Poly A, RNA, Messenger, Saccharomyces cerevisiae, RNA-Binding Proteins, mRNA Cleavage and Polyadenylation Factors
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