Cited by 250RNA Research and SplicingDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

G-quadruplex RNA structure as a signal for neurite mRNA targeting

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Subramanian, Murugan, Rage, Florence, Tabet, Ricardos, Flatter, Eric, Mandel, Jean‐Louis, Moine, Hervé·2011·The EMBO Reports

Abstract

Targeting of messenger RNAs (mRNAs) in neuron processes relies on cis-acting regulatory elements, the nature of which is poorly understood. Here, we report that approximately 30% of the best-known dendritic mRNAs contain a guanine (G)-quadruplex consensus in their 3'-untranslated region. Among these mRNAs, we show by using RNA structure probing that a G-quadruplex is present in the mRNAs of two key postsynaptic proteins: PSD-95 and CaMKIIa. The G-quadruplex structure is necessary and sufficient for the potent and fast localization of mRNAs in cortical neurites and this occurs in a metabotropic glutamate receptor-responsive manner. Thus, G-quadruplex seems to be a common neurite localization signal.

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Crossref · 10.1038/embor.2011.76

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Authors
Subramanian, M., Rage, F., Tabet, R., Flatter, E., Mandel, J., & Moine, H.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Institut de Génétique Moléculaire de Montpellier (FR)
Corresponding author
Moine, Hervé
Venue
The EMBO Reports
Published
2011-05-13
Volume
12
Issue
7
Pages
697-704
ISSN
  • 1469-221X (ISSN-L)
  • 1469-3178
OpenAlex
W2163533539
Cited by
250
References
30
Citations by year
2026: 6 · 2025: 13 · 2024: 10 · 2023: 20 · 2022: 18 · 2021: 19 · 2020: 28 · 2019: 19 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 22 · 2014: 16 · 2013: 16 · 2012: 14
FWCI
7.00
Type
journal article
Language
en
Open access
Locations
  • EMBO Reports (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
mRNA localization, dendritic mRNA, 3' untranslated region, PSD-95, postsynaptic proteins, cis-regulatory elements
MeSH terms
Disks Large Homolog 4 Protein, Animals, Base Sequence, Humans, Membrane Proteins, Mice, Inbred C57BL, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Messenger, Neurites, RNA Transport, Intracellular Signaling Peptides and Proteins, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2, G-Quadruplexes

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