G-quadruplex RNA structure as a signal for neurite mRNA targeting
Open accessAbstract
Targeting of messenger RNAs (mRNAs) in neuron processes relies on cis-acting regulatory elements, the nature of which is poorly understood. Here, we report that approximately 30% of the best-known dendritic mRNAs contain a guanine (G)-quadruplex consensus in their 3'-untranslated region. Among these mRNAs, we show by using RNA structure probing that a G-quadruplex is present in the mRNAs of two key postsynaptic proteins: PSD-95 and CaMKIIa. The G-quadruplex structure is necessary and sufficient for the potent and fast localization of mRNAs in cortical neurites and this occurs in a metabotropic glutamate receptor-responsive manner. Thus, G-quadruplex seems to be a common neurite localization signal.
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RNA G-quadruplex-forming structures are involved in several steps of mRNA metabolism.
“RNA G-quadruplex-forming structures are involved in several steps of mRNA metabolism (Melko and Bardoni, 2010; Subramanian et al., 2011).”
From New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes (2017) · cites this paper as Subramanian et al., 2011
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Kinesin superfamily motor proteins and intracellular transport
Hirokawa, N., Noda, Y., Tanaka, Y., & Niwa, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2774 · Cited by 1,859 · cited 3× · see citing works
“G–quadruplex RNA structure as a signal for neurite mRNA targeting”
BackgroundmRNA localization: Gene expression in the spatial dimension
Martin, K. C., & Ephrussi, A. (2009) · Cell · doi:10.1016/j.cell.2009.01.044 · Cited by 1,048 · see citing works
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T., & Darnell, R. B. (2001) · Cell · doi:10.1016/s0092-8674(01)00566-9 · Cited by 952 · see citing works
Translational control of long-lasting synaptic plasticity and memory
Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944 · see citing works
Dendritic Protein Synthesis, Synaptic Plasticity, and Memory
Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 894 · see citing works
G-quadruplex structures: in vivo evidence and function
Lipps, H. J., & Rhodes, D. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.05.002 · Cited by 829 · see citing works
Spatial regulation of β-actin translation by Src-dependent phosphorylation of ZBP1
Hüttelmaier, S., Zenklusen, D., Lederer, M., Dictenberg, J., Lorenz, M., Meng, X.-H., Bassell, G., Condeelis, J., & Singer, R. (2005) · Nature · doi:10.1038/nature04115 · Cited by 681 · see citing works
Dendritic mRNA: transport, translation and function
Bramham, C. R., & Wells, D. G. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2150 · Cited by 574 · see citing works
Burgin, K., Waxham, M., Rickling, S., Westgate, S., Mobley, W. C., & Kelly, P. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-06-01788.1990 · Cited by 564 · see citing works
Kislauskis, E., Zhu, X., & Singer, R. H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.2.441 · Cited by 511 · see citing works
Dictenberg, J. B., Swanger, S. A., Antar, L. N., Singer, R. H., & Bassell, G. J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.04.003 · Cited by 511 · see citing works
The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
Schaeffer, C., Bardoni, B., Mandel, J., Ehresmann, B., Ehresmann, C., & Moine, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4803 · Cited by 471 · see citing works
Self-citationMuddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0937-07.2007 · Cited by 421 · see citing works
Subcellular mRNA Localization in Animal Cells and Why It Matters
Holt, C. E., & Bullock, S. L. (2009) · Science · doi:10.1126/science.1176488 · Cited by 418 · see citing works
Translational control of localized mRNAs: restricting protein synthesis in space and time
Besse, F., & Ephrussi, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2548 · Cited by 373 · see citing works
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
Zalfa, F., Eleuteri, B., Dickson, K. S., Mercaldo, V., Rubeis, S. D., di Penta, A., Tabolacci, E., Chiurazzi, P., Neri, G., Grant, S. G. N., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1893 · Cited by 364 · see citing works
Mayford, M., Baranes, D., Podsypanina, K., & Kandel, E. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.23.13250 · Cited by 346 · see citing works
To localize or not to localize: mRNA fate is in 3′UTR ends
Andreassi, C., & Riccio, A. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.06.001 · Cited by 338 · see citing works
Barciszewski, J. (2023) · RNA technologies · doi:10.1007/978-3-031-36390-0 · Cited by 283 · see citing works
Todd, P. K., Mack, K. J., & Malter, J. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336265100 · Cited by 280 · see citing works
Facilitation of dendritic mRNA transport by CPEBPreprint
Huang, Y., Carson, J. H., Barbarese, E., & Richter, J. D. (2003) · Genes & Development · doi:10.1101/gad.1053003 · Cited by 265 · see citing works
λN-GFP: an RNA reporter system for live-cell imaging
Daigle, N., & Ellenberg, J. (2007) · Nature Methods · doi:10.1038/nmeth1065 · Cited by 228 · see citing works
In Situ Hybridization Histochemistry
Young, W. S. (1989) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-10726-1_1 · Cited by 213 · see citing works
The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer
Didiot, M.-C., Tian, Z., Schaeffer, C., Subramanian, M., Mandel, J., & Moine, H. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn472 · Cited by 196 · see citing works
Self-citationTwo cis-acting elements in the 3′ untranslated region of α-CaMKII regulate its dendritic targeting
Mori, Y., Imaizumi, K., Katayama, T., Yoneda, T., & Tohyama, M. (2000) · Nature Neuroscience · doi:10.1038/80591 · Cited by 186 · see citing works
Cougot, N., Bhattacharyya, S. N., Tapia-Arancibia, L., Bordonné, R., Filipowicz, W., Bertrand, E., & Rage, F. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4155-08.2008 · Cited by 165 · see citing works
Self-citationLiu, D. (2024) · CRC Press eBooks · doi:10.1201/9781003055211-13 · Cited by 157 · see citing works
Kao, D.-I., Aldridge, G. M., Weiler, I. J., & Greenough, W. T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010564107 · Cited by 143 · see citing works
GRSDB2 and GRS_UTRdb: databases of quadruplex forming G-rich sequences in pre-mRNAs and mRNAs
Kikin, O., Zappala, Z., D’Antonio, L., & Bagga, P. S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm982 · Cited by 115 · see citing works
RNA localization and polarity: from A(PC) to Z(BP)
Mili, S., & Macara, I. G. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.02.001 · Cited by 57 · see citing works
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Varshney, D., Spiegel, J., Zyner, K. G., Tannahill, D., & Balasubramanian, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0236-x · Cited by 1,265 · see citing works
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Leal, G., Comprido, D., & Duarte, C. B. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.005 · Cited by 685 · see citing works
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Bugaut, A., & Balasubramanian, S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks068 · Cited by 643 · see citing works
Biffi, G., Antonio, M. D., Tannahill, D., & Balasubramanian, S. (2013) · Nature Chemistry · doi:10.1038/nchem.1805 · Cited by 608 · see citing works
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Guo, J. U., & Bartel, D. P. (2016) · Science · doi:10.1126/science.aaf5371 · Cited by 472 · see citing works
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Wan, Y., Kertesz, M., Spitale, R. C., Segal, E., & Chang, H. Y. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3049 · Cited by 469 · see citing works
RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms
Fay, M. M., Lyons, S. M., & Ivanov, P. V. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.05.017 · Cited by 448 · see citing works
Intracellular mRNA transport and localized translation
Das, S., Vera, M., Gandin, V., Singer, R. H., & Tutucci, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00356-8 · Cited by 384 · see citing works
Tushev, G., Glock, C., Heumüller, M., Biever, A., Jovanovic, M., & Schuman, E. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.030 · Cited by 377 · see citing works
Fratta, P., Mizielinska, S., Nicoll, A. J., Zloh, M., Fisher, E., Parkinson, G. N., & Isaacs, A. M. (2012) · Scientific Reports · doi:10.1038/srep01016 · Cited by 335 · see citing works
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Jung, H., Gkogkas, C. G., Sonenberg, N., & Holt, C. E. (2014) · Cell · doi:10.1016/j.cell.2014.03.005 · Cited by 302 · see citing works
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Richter, J. D., Bassell, G. J., & Klann, E. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4001 · Cited by 275 · see citing works
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Doyle, M., & Kiebler, M. A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.278 · Cited by 288 · see citing works
Millevoi, S., Moine, H., & Vagner, S. (2012) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1113 · Cited by 277 · see citing works
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Zamiri, B., Reddy, K., Macgregor, R. B., & Pearson, C. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.502336 · Cited by 220 · see citing works
G‐quadruplexes: Emerging roles in neurodegenerative diseases and the non‐coding transcriptome
Simone, R., Fratta, P., Neidle, S., Parkinson, G. N., & Isaacs, A. M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.003 · Cited by 216 · see citing works
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Cammas, A., & Millevoi, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1280 · Cited by 219 · see citing works
Vasilyev, N., Polonskaia, A., Darnell, J. C., Darnell, R. B., Patel, D. J., & Serganov, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515737112 · Cited by 202 · see citing works
Beaudoin, J.-D., & Perreault, J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt265 · Cited by 169 · see citing works
Agarwala, P., Pandey, S., & Maiti, S. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob02681k · Cited by 168 · see citing works
The Kinetics and Folding Pathways of Intramolecular G-Quadruplex Nucleic Acids
Zhang, A. Y. Q., & Balasubramanian, S. (2012) · Journal of the American Chemical Society · doi:10.1021/ja309851t · Cited by 164 · see citing works
Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back
Kharel, P., Becker, G., Цветков, В. Б., & Ivanov, P. V. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1126 · Cited by 163 · see citing works
RNA G-quadruplexes and their potential regulatory roles in translation
Song, J., Perreault, J., Topisirović, I., & Richard, S. (2016) · Translation · doi:10.1080/21690731.2016.1244031 · Cited by 153 · see citing works
Maurin, T., Lebrigand, K., Castagnola, S., Paquet, A. C., Jarjat, M., Popa, A., Grossi, M., Rage, F., & Bardoni, B. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky267 · Cited by 152 · see citing works
Self-citationG-Quadruplexes as pathogenic drivers in neurodegenerative disorders
Wang, E., Thombre, R., Shah, Y., Latanich, R., & Wang, J. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab164 · Cited by 148 · see citing works
Piazza, A., Adrian, M., Samazan, F., Heddi, B., Hamon, F., Serero, A., Lopes, J., Teulade‐Fichou, M., Phan, A. T., & Nicolas, A. G. (2015) · The EMBO Journal · doi:10.15252/embj.201490702 · Cited by 142 · see citing works
Goering, R., Hudish, L. I., Guzmán, B. B., Raj, N., Bassell, G. J., Russ, H. A., Dominguez, D., & Taliaferro, J. M. (2020) · eLife · doi:10.7554/elife.52621 · Cited by 132 · see citing works
The diverse structural landscape of quadruplexes
Lightfoot, H., Hagen, T., Tatum, N., & Hall, J. (2019) · FEBS Letters · doi:10.1002/1873-3468.13547 · Cited by 114 · see citing works
Stress promotes RNA G-quadruplex folding in human cells
Kharel, P., Fay, M. M., Manasova, E. V., Anderson, P., Kurkin, A. V., Guo, J. U., & Ivanov, P. V. (2023) · Nature Communications · doi:10.1038/s41467-023-35811-x · Cited by 131 · see citing works
Effect of loops and G-quartets on the stability of RNA G-quadruplexes.
Pandey, S., Agarwala, P., & Maiti, S. (2013) · Journal of Physical Chemistry B · doi:10.1021/jp401739m · Cited by 116 · see citing works
TDP ‐43 binds and transports G ‐quadruplex‐containing m RNA s into neurites for local translation
Ishiguro, A., Kimura, N., Watanabe, Y., Watanabe, S., & Ishihama, A. (2016) · Genes to Cells · doi:10.1111/gtc.12352 · Cited by 120 · see citing works
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Janusz, A., Miłek, J., Perycz, M., Pacini, L., Bagni, C., Kaczmarek, L., & Dziembowska, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2207-13.2013 · Cited by 112 · see citing works
Fragile X Syndrome: from molecular pathology to therapy
Maurin, T., Zongaro, S., & Bardoni, B. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.006 · Cited by 113 · see citing works
Banerjee, A., Ifrim, M. F., Valdez‐Sinon, A. N., Raj, N., & Bassell, G. J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.008 · Cited by 103 · see citing works
Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back
Gross, C., Hoffmann, A., Bassell, G. J., & Berry-Kravis, E. M. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0355-9 · Cited by 105 · see citing works
The role of RNA G‐quadruplexes in human diseases and therapeutic strategies
Kharel, P., Balaratnam, S., Beals, N., & Basu, S. (2019) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1568 · Cited by 105 · see citing works
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Tabet, R., Moutin, E., Becker, J. A. J., Heintz, D., Fouillen, L., Flatter, E., Krężel, W., Alunni, V., Koebel, P., Dembélé, D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522631113 · Cited by 103 · see citing works
Self-citation3′ UTR G-quadruplexes regulate miRNA binding
Rouleau, S. G., Glouzon, J.-P. S., Brumwell, A., Bisaillon, M., & Perreault, J. (2017) · RNA · doi:10.1261/rna.060962.117 · Cited by 104 · see citing works
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The Conservation and Function of RNA Secondary Structure in Plants
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Lee, D. S. M., Ghanem, L. R., & Barash, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-14404-y · Cited by 97 · see citing works
Burguete, A. S., Almeida, S., Gao, F., Kalb, R. G., Akins, M. R., & Bonini, N. M. (2015) · eLife · doi:10.7554/elife.08881 · Cited by 94 · see citing works
G-quadruplex in cancer biology and drug discovery
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Ifrim, M. F., Williams, K. R., & Bassell, G. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2802-14.2015 · Cited by 89 · see citing works
Roles of non-canonical structures of nucleic acids in cancer and neurodegenerative diseases
Tateishi‐Karimata, H., & Sugimoto, N. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab580 · Cited by 89 · see citing works
A stable RNA G-quadruplex within the 5′-UTR of Arabidopsis thaliana ATR mRNA inhibits translation
Kwok, C. K., Ding, Y., Shahid, S., Assmann, S. M., & Bevilacqua, P. C. (2015) · Biochemical Journal · doi:10.1042/bj20141063 · Cited by 88 · see citing works
Single-molecule insights into mRNA dynamics in neurons
Buxbaum, A. R., Yoon, Y. J., Singer, R. H., & Park, H. Y. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.05.005 · Cited by 86 · see citing works
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Lammich, S., Kamp, F., Wagner, J., Nuscher, B., Zilow, S., Ludwig, A., Willem, M., & Haass, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.296921 · Cited by 84 · see citing works
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Matsuo, K., Asamitsu, S., Maeda, K., Suzuki, H., Kawakubo, K., Komiya, G., Kudo, K., Sakai, Y., Hori, K., Ikenoshita, S., et al. (2024) · Cell · doi:10.1016/j.cell.2024.09.037 · Cited by 82 · see citing works
The travels of mRNAs in neurons: do they know where they are going?
Das, S., Singer, R. H., & Yoon, Y. J. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.01.016 · Cited by 81 · see citing works
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The G-Quadruplex Augments Translation in the 5′ Untranslated Region of Transforming Growth Factor β2
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Bae, B., & Miura, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103413 · Cited by 74 · see citing works
Davidovic, L., Durand, N., Khalfallah, O., Tabet, R., Barbry, P., Mari, B. P., Sacconi, S., Moine, H., & Bardoni, B. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003367 · Cited by 75 · see citing works
Self-citationNeurodegenerative diseases: Quantitative predictions of protein–RNA interactions
Cirillo, D., Agostini, F., Klus, P., Marchese, D., Rodriguez-Mulero, S., Bolognesi, B., & Tartaglia, G. G. (2012) · RNA · doi:10.1261/rna.034777.112 · Cited by 74 · see citing works
Middleton, S. A., Eberwine, J. H., & Kim, J. (2019) · BMC Biology · doi:10.1186/s12915-019-0630-z · Cited by 74 · see citing works
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Nainar, S., Marshall, P. R., Steadman, C. R., Spitale, R. C., & Bredy, T. W. (2016) · Nature Neuroscience · doi:10.1038/nn.4378 · Cited by 69 · see citing works
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Imperatore, J. A., McAninch, D. S., Valdez‐Sinon, A. N., Bassell, G. J., & Mihailescu, M. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00006 · Cited by 66 · see citing works
Recent advances in RNA structurome
Xu, B., Zhu, Y., Cao, C., Chen, H., Jin, Q., Li, G., Ma, J., Yang, S. L., Zhao, J., Zhu, J., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2116-2 · Cited by 62 · see citing works
Identification of a cis-acting element that localizes mRNA to synapses
Meer, E. J., Wang, D. O., Kim, S., Barr, I., Guo, F., & Martin, K. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116269109 · Cited by 65 · see citing works
Ishiguro, A., Lu, J., Ozawa, D., Nagai, Y., & Ishihama, A. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101284 · Cited by 64 · see citing works
Lee, S. C., Zhang, J. Y., Strom, J. G., Yang, D., Dinh, T. N., Kappeler, K. V., & Chen, Q. M. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00122-16 · Cited by 64 · see citing works
QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs
Frees, S., Menendez, C., Crum, M., & Bagga, P. S. (2014) · Human Genomics · doi:10.1186/1479-7364-8-8 · Cited by 62 · see citing works
G-Quadruplexes in Neurobiology and Virology: Functional Roles and Potential Therapeutic Approaches
Xu, J., Huang, H., & Zhou, X. (2021) · JACS Au · doi:10.1021/jacsau.1c00451 · Cited by 61 · see citing works
mRNA Localization: An Orchestration of Assembly, Traffic and Synthesis
Xing, L., & Bassell, G. J. (2012) · Traffic · doi:10.1111/tra.12004 · Cited by 61 · see citing works
Marshall, P. R., & Bredy, T. W. (2016) · npj Science of Learning · doi:10.1038/npjscilearn.2016.14 · Cited by 58 · see citing works
G-Quadruplex-Induced Liquid–Liquid Phase Separation in Biomimetic Protocells
Liu, X., Xiong, Y., Zhang, C., Lai, R., Liu, H., Peng, R., Fu, T., Liu, Q., Fang, X., Mann, S., et al. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c03627 · Cited by 60 · see citing works
Abekhoukh, S., Sahin, H. B., Grossi, M., Zongaro, S., Maurin, T., Madrigal, I., Kazue-Sugioka, D., Raas-Rothschild, A., Doulazmi, M., Carrera, P., et al. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.025809 · Cited by 59 · see citing works
“RNA G-quadruplex-forming structures are involved in several steps of mRNA metabolism (Melko and Bardoni, 2010; Subramanian et al., 2011).”
FMRP interacts with G-quadruplex structures in the 3’-UTR of its dendritic target Shank1 mRNA
Zhang, Y., Gaetano, C. M., Williams, K. R., Bassell, G. J., & Mihailescu, M. (2014) · RNA Biology · doi:10.1080/15476286.2014.996464 · Cited by 58 · see citing works
Zhang, J., Harvey, S. E., & Cheng, C. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz036 · Cited by 59 · see citing works
Alternative polyadenylation in the nervous system: To what lengths will 3′ UTR extensions take us?
Miura, P., Sanfilippo, P., Shenker, S., & Lai, E. C. (2014) · BioEssays · doi:10.1002/bies.201300174 · Cited by 57 · see citing works
Identification and targeting of G-quadruplex structures in MALAT1 long non-coding RNA
Mou, X., Liew, S. W., & Kwok, C.-K. (2021) · bioRxiv · doi:10.1093/nar/gkab1208 · Cited by 46 · see citing works
Stefanovic, S., Bassell, G. J., & Mihailescu, M. (2014) · RNA · doi:10.1261/rna.046722.114 · Cited by 56 · see citing works
Perspectives for Applying G-Quadruplex Structures in Neurobiology and Neuropharmacology
Asamitsu, S., Takeuchi, M., Ikenoshita, S., Imai, Y., Kashiwagi, H., & Shioda, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122884 · Cited by 56 · see citing works
RNA localization mechanisms transcend cell morphology
Goering, R., Arora, A., Pockalny, M. C., & Taliaferro, J. M. (2023) · eLife · doi:10.7554/elife.80040 · Cited by 48 · see citing works
Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex
Crenshaw, E. M. D., Leung, B. C. L., Kwok, C. K., Sharoni, M. A., Olson, K. J., Sebastian, N. P., Ansaloni, S., Schweitzer‐Stenner, R., Akins, M. R., Bevilacqua, P. C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143160 · Cited by 53 · see citing works
High-throughput identification of RNA localization elements in neuronal cells
Arora, A., Castro-Gutiérrez, R., Moffatt, C., Eletto, D., Becker, R., Brown, M. R., Moor, A. E., Russ, H. A., & Taliaferro, J. M. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac763 · Cited by 52 · see citing works
RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates
Hase, K., Fujiwara, Y., Kikuchi, H., Aizawa, S., Hakuno, F., Takahashi, S., Wada, K., & Kabuta, T. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv579 · Cited by 52 · see citing works
Plant 3’ Regulatory Regions From mRNA-Encoding Genes and Their Uses to Modulate Expression
Bernardes, W. S., & Menossi, M. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.01252 · Cited by 50 · see citing works
Irregular G-quadruplexes Found in the Untranslated Regions of Human mRNAs Influence Translation
Bolduc, F., Garant, J., Allard, F., & Perreault, J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.744839 · Cited by 51 · see citing works
Masai, H., & Tanaka, T. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.05.132 · Cited by 50 · see citing works
Ghosh, A., Pandey, S., Joshi, D. C., Rana, P., Ansari, A. H., Sundar, J. S., Singh, P., Khan, Y., Ekka, M. K., Chakraborty, D., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad639 · Cited by 49 · see citing works
Matsumoto, S., Tateishi‐Karimata, H., Takahashi, S., Ohyama, T., & Sugimoto, N. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00346 · Cited by 48 · see citing works
Marchand, V., Gáspár, I., & Ephrussi, A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.12.014 · Cited by 47 · see citing works
Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae
Piazza, A., Cui, X., Adrian, M., Samazan, F., Heddi, B., Phan, A. T., & Nicolas, A. G. (2017) · eLife · doi:10.7554/elife.26884 · Cited by 44 · see citing works
RNA G-quadruplex in functional regulation of noncoding RNA: Challenges and emerging opportunities
Sahayasheela, V. J., & Sugiyama, H. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.08.010 · Cited by 43 · see citing works
Epigenetic Modulation of Chromatin States and Gene Expression by G-Quadruplex Structures
Reina, C., & Cavalieri, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114172 · Cited by 41 · see citing works
Thomsen, R., Pallesen, J., Daugaard, T. F., Børglum, A. D., & Nielsen, A. L. (2013) · Glia · doi:10.1002/glia.22569 · Cited by 40 · see citing works
Taking a cellular road-trip: mRNA transport and anchoring
Pratt, C. A., & Mowry, K. L. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.015 · Cited by 39 · see citing works
Zhang, P., Abdelmohsen, K., Liu, Y., Tominaga, K., Yoon, J., Grammatikakis, I., Martindale, J. L., Zhang, Y., Becker, K. G., Yang, I. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms9888 · Cited by 38 · see citing works
RNA Misprocessing in C9orf72-Linked Neurodegeneration
Barker, H., Niblock, M., Lee, Y., Shaw, C. E., & Gallo, J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00195 · Cited by 39 · see citing works
Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches
Rouleau, S. G., Beaudoin, J.-D., Bisaillon, M., & Perreault, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1311 · Cited by 35 · see citing works
G‐quadruplex regulation of neural gene expression
Cave, J. W., & Willis, D. E. (2021) · FEBS Journal · doi:10.1111/febs.15900 · Cited by 38 · see citing works
Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., & Yoshii, K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704454114 · Cited by 36 · see citing works
Ishiguro, A., Kimura, N., Noma, T., Shimo‐Kon, R., Ishihama, A., & Kon, T. (2020) · FEBS Letters · doi:10.1002/1873-3468.13800 · Cited by 37 · see citing works
- Authors
- Subramanian, M., Rage, F., Tabet, R., Flatter, E., Mandel, J., & Moine, H.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut de Génétique Moléculaire de Montpellier (FR)
- Corresponding author
- Moine, Hervé
- Venue
- The EMBO Reports
- Published
- 2011-05-13
- Volume
- 12
- Issue
- 7
- Pages
- 697-704
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC3128965
- OpenAlex
- W2163533539
- Cited by
- 250
- References
- 30
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 10 · 2023: 20 · 2022: 18 · 2021: 19 · 2020: 28 · 2019: 19 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 22 · 2014: 16 · 2013: 16 · 2012: 14
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- mRNA localization, dendritic mRNA, 3' untranslated region, PSD-95, postsynaptic proteins, cis-regulatory elements
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Base Sequence, Humans, Membrane Proteins, Mice, Inbred C57BL, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Messenger, Neurites, RNA Transport, Intracellular Signaling Peptides and Proteins, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2, G-Quadruplexes
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