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Rfam 12.0: updates to the RNA families database

Open access
Nawrocki, Eric P., Burge, Sarah W., Bateman, Alex, Daub, Jennifer, Eberhardt, Ruth Y., Eddy, Sean R., Floden, Evan W., Gardner, Paul P., Jones, Thomas A., Tate, John, Finn, Robert D.·2015·Nucleic Acids Research

Abstract

The Rfam database (available at http://rfam.xfam.org) is a collection of non-coding RNA families represented by manually curated sequence alignments, consensus secondary structures and annotation gathered from corresponding Wikipedia, taxonomy and ontology resources. In this article, we detail updates and improvements to the Rfam data and website for the Rfam 12.0 release. We describe the upgrade of our search pipeline to use Infernal 1.1 and demonstrate its improved homology detection ability by comparison with the previous version. The new pipeline is easier for users to apply to their own data sets, and we illustrate its ability to annotate RNAs in genomic and metagenomic data sets of various sizes. Rfam has been expanded to include 260 new families, including the well-studied large subunit ribosomal RNA family, and for the first time includes information on short sequence- and structure-based RNA motifs present within families.

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Crossref · 10.1093/nar/gku1063

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Metadata

Authors
Nawrocki, E. P., Burge, S. W., Bateman, A., Daub, J., Eberhardt, R. Y., Eddy, S. R., Floden, E. W., Gardner, P. P., Jones, T. A., Tate, J., & Finn, R. D.
Venue
Nucleic Acids Research
Published
2014-11-11
Volume
43
Issue
D1
Pages
D130-D137
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2108230379
Cited by
1,071
References
5
FWCI
41.37
Type
journal article
Language
en
Open access
gold

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