The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
The effect of tRNA levels on decoding times of mRNA codons
Open accessAbstract
The possible effect of transfer ribonucleic acid (tRNA) concentrations on codons decoding time is a fundamental biomedical research question; however, due to a large number of variables affecting this process and the non-direct relation between them, a conclusive answer to this question has eluded so far researchers in the field. In this study, we perform a novel analysis of the ribosome profiling data of four organisms which enables ranking the decoding times of different codons while filtering translational phenomena such as experimental biases, extreme ribosomal pauses and ribosome traffic jams. Based on this filtering, we show for the first time that there is a significant correlation between tRNA concentrations and the codons estimated decoding time both in prokaryotes and in eukaryotes in natural conditions (-0.38 to -0.66, all P values <0.006); in addition, we show that when considering tRNA concentrations, codons decoding times are not correlated with aminoacyl-tRNA levels. The reported results support the conjecture that translation efficiency is directly influenced by the tRNA levels in the cell. Thus, they should help to understand the evolution of synonymous aspects of coding sequences via the adaptation of their codons to the tRNA pool.
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Cited by
Codon influence on protein expression in E. coli correlates with mRNA levels
Boël, G., Letso, R., Neely, H., Price, W. N., Wong, K.-H., Su, M., Luff, J. D., Valecha, M., Everett, J. K., Acton, T. B., et al. (2016) · Nature · doi:10.1038/nature16509 · Cited by 440
Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations
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Chloroplast Translation: Structural and Functional Organization, Operational Control, and Regulation
Zoschke, R., & Bock, R. (2018) · The Plant Cell · doi:10.1105/tpc.18.00016 · Cited by 285
Monosomes actively translate synaptic mRNAs in neuronal processes
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Multiple roles of the coding sequence 5′ end in gene expression regulation
Tuller, T., & Zur, H. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1313 · Cited by 206
Self-citation
Metadata
- Authors
- Dana, A., & Tuller, T.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-07-23
- Volume
- 42
- Issue
- 14
- Pages
- 9171-9181
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2147837708
- Cited by
- 263
- References
- 79
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- gold
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