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Cited by 2,759RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancerRNA Research and Splicing

The mechanism of eukaryotic translation initiation and principles of its regulation

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Jackson, Richard J., Hellen, Christopher U. T., Pestova, Tatyana V.·2010·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm2838PMC PMC4461372
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Abstract

Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial control of gene expression. Progress over recent years in determining the structures and activities of initiation factors, and in mapping their interactions in ribosomal initiation complexes, have advanced our understanding of the complex translation initiation process. These developments have provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity (which affects almost all scanning-dependent initiation) and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).

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Authors
Jackson, R. J., Hellen, C. U. T., & Pestova, T. V.
Affiliations
  • University of Cambridge (GB)
  • SUNY Downstate Health Sciences University (US)
ORCID
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2010-02
Volume
11
Issue
2
Pages
113-127
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm2838
PMC
PMC4461372
OpenAlex
W2008410413
Cited by
2,759
References
0
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FWCI
15.20
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Wellcome Trust
  • Biotechnology and Biological Sciences Research Council
  • National Institute of General Medical Sciences (R01GM063940, R01GM080623, R01GM059660)
  • National Institute of Allergy and Infectious Diseases (R56AI051340, R01AI051340)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
translation initiation, eukaryotic translation, initiation factors, RNA-binding proteins, microRNA, protein synthesis regulation
MeSH terms
Animals, Gene Expression Regulation, Humans, Protein Biosynthesis, RNA-Binding Proteins, MicroRNAs, Eukaryotic Initiation Factors, Eukaryota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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