Cited by 393Circular RNAs in diseasesRNA Research and SplicingRNA and protein synthesis mechanisms

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RNA circularization strategies in vivo and in vitro

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Petkovic, Sonja, Müller, Sabine·2015·Nucleic Acids Research

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Abstract

In the plenitude of naturally occurring RNAs, circular RNAs (circRNAs) and their biological role were underestimated for years. However, circRNAs are ubiquitous in all domains of life, including eukaryotes, archaea, bacteria and viruses, where they can fulfill diverse biological functions. Some of those functions, as for example playing a role in the life cycle of viral and viroid genomes or in the maturation of tRNA genes, have been elucidated; other putative functions still remain elusive. Due to the resistance to exonucleases, circRNAs are promising tools for in vivo application as aptamers, trans-cleaving ribozymes or siRNAs. How are circRNAs generated in vivo and what approaches do exist to produce ring-shaped RNAs in vitro? In this review we illustrate the occurrence and mechanisms of RNA circularization in vivo, survey methods for the generation of circRNA in vitro and provide appropriate protocols.

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RETRACTED: Construction of circular miRNA sponges targeting miR-21 or miR-221and demonstration of their excellent anticancer effects on malignant melanoma cells
Liu, Y., Cui, H., Wang, W., Li, L., Wang, Z., Yang, S., & Zhang, X. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.03.013 · Cited by 42
Retracted
Circular RNAs are a large class of animal RNAs with regulatory potency
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Additional file 12 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
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Additional file 4 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
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Additional file 2 of SRCP: a comprehensive pipeline for accurate annotation and quantification of circRNAs
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Additional file 14 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
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Additional file 5 of Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress
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Additional file 4 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
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Additional file 11 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
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Additional file 10 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636250
Additional file 2 of Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress
Wang, R., Zhang, M., Wang, H., Liangliang, C. H. E. N., Zhang, X., Guo, L., Qi, T., Tang, H., Shahzad, K., Hailin, W. A. N. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26662966
Additional file 8 of Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress
Wang, R., Zhang, M., Wang, H., Liangliang, C. H. E. N., Zhang, X., Guo, L., Qi, T., Tang, H., Shahzad, K., Hailin, W. A. N. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26662987
Additional file 13 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636259
Additional file 3 of Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress
Wang, R., Zhang, M., Wang, H., Liangliang, C. H. E. N., Zhang, X., Guo, L., Qi, T., Tang, H., Shahzad, K., Hailin, W. A. N. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26662969
Additional file 4 of Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress
Wang, R., Zhang, M., Wang, H., Liangliang, C. H. E. N., Zhang, X., Guo, L., Qi, T., Tang, H., Shahzad, K., Hailin, W. A. N. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26662975
Additional file 1 of Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress
Wang, R., Zhang, M., Wang, H., Liangliang, C. H. E. N., Zhang, X., Guo, L., Qi, T., Tang, H., Shahzad, K., Hailin, W. A. N. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26662963
Additional file 7 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636241
Additional file 19 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636277
Additional file 1 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219259
Additional file 5 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636235
Additional file 10 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219238
Additional file 3 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636229
Additional file 2 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219262
Additional file 11 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219244
Additional file 18 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636274
Additional file 6 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219274
Additional file 17 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636271
Additional file 7 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219277
Additional file 6 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636238
Additional file 9 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636247
Additional file 2 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24516078
Additional file 15 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636265
Additional file 6 of Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress
Wang, R., Zhang, M., Wang, H., Liangliang, C. H. E. N., Zhang, X., Guo, L., Qi, T., Tang, H., Shahzad, K., Hailin, W. A. N. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26662981
Additional file 16 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636268
Additional file 7 of SRCP: a comprehensive pipeline for accurate annotation and quantification of circRNAs
Rabin, A., Zaffagni, M., Ashwal-Fluss, R., Patop, I. L., Jajoo, A., Shenzis, S., Carmel, L., & Kadener, S. (2021) · Figshare · doi:10.6084/m9.figshare.16674690
Additional file 3 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219265
Additional file 14 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636262
Additional file 8 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219280
Additional file 7 of Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress
Wang, R., Zhang, M., Wang, H., Liangliang, C. H. E. N., Zhang, X., Guo, L., Qi, T., Tang, H., Shahzad, K., Hailin, W. A. N. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26662984
Additional file 9 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219283
Additional file 12 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636256
Additional file 5 of Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13219271
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Authors: Petkovic, S., & Müller, S.
Affiliations: Universität Greifswald (DE)
Corresponding author: Müller, Sabine
ORCID: Petkovic, Sonja
Müller, Sabine
Venue: Nucleic Acids Research
Publisher: Oxford University Press (OUP)
Published: 2015-02-06
Volume: 43
Issue: 4
Pages: 2454-2465
ISSN: 0305-1048 (ISSN-L)
1362-4962
DOI: 10.1093/nar/gkv045
PMC: PMC4344496
OpenAlex: W2121626677
Cited by: 386
References: 128
Citations by year: 2026: 21 · 2025: 42 · 2024: 51 · 2023: 39 · 2022: 40 · 2021: 51 · 2020: 46 · 2019: 31 · 2018: 26 · 2017: 18 · 2016: 15 · 2015: 5
FWCI: 2.07
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor, 640 d)
Locations: Nucleic Acids Research (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: University of Oxford
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: circular RNA, RNA circularization, aptamers, siRNA, tRNA maturation, RNA biogenesis
MeSH terms: RNA, Circular, Exons, Introns, RNA Ligase (ATP), RNA, RNA, Viral, RNA, Archaeal

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