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PANTHER version 10: expanded protein families and functions, and analysis tools
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Identification of WASH-FAM21-CCC-retriever-SNX17 pathway provides a mechanism to account for several studies showing role for WASH complex in α5β1-integrin recycling even though sorting of this cargo is retromer-independent.
“Importantly, the identification of the WASH-FAM21-CCC-retriever-SNX17 pathway provides a mechanism to account for several studies that have shown a role for the WASH complex in α5β1-integrin recycling even though the sorting of this cargo is known to be retromer-independent26, 56–58.”
From Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling (2017) · cites this paper as [56]
Our copy discusses PANTHER protein families and analysis tools, including the Prowler interface (Website and Analysis Tool Improvements; page unavailable). Searches for the WASH–FAM21–CCC–retriever–SNX17 pathway and for integrin recycling found no passage addressing the proposed mechanism or retromer-independent sorting. (LLM, conf=0.78)
Experimental — accuracy not yet measuredEndosomal association of FAM21 and WASH is mediated through both retromer-dependent and retromer-independent mechanisms in human cells.
“This clearly establishes that in human cells the endosomal association of FAM21 and WASH is mediated through both retromer-dependent and retromer-independent mechanisms, a conclusion that is in agreement with work in Dictyostelium describing the retromer-independent recruitment of the WASH complex56.”
From Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling (2017) · cites this paper as [56]
The cited paper’s Improved phylogenetic trees and Prowler in JavaScript sections (pages not provided) discuss PANTHER data and tools, not endosomal recruitment. Searches for FAM21, WASH, retromer-dependent mechanisms, and Dictyostelium recruitment found no passage addressing the claim. (LLM, conf=0.78)
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Research works printed but not linked: 18
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- Koonin E.V. Galperin M.Y. Sequence - Evolution - Function: Computational Approaches in Comparative Genomics. Boston: Kluwer Academic; 2003. Evolutionary Concept in Genetics and Genomics. · DOI
- Thomas P.D. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. Chichester: Wiley; 2006. PANTHER: Protein families and subfamilies modeled on the divergence of function. p. 1-5. · DOI
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Metadata
- Authors
- Mi, H., Poudel, S., Muruganujan, A., Casagrande, J. T., & Thomas, P. D.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-11-17
- Volume
- 44
- Issue
- D1
- Pages
- D336-D342
- ISSN
- 0305-1048
- 1362-4962
- PMC
- PMC4702852
- Cited by
- 770
- References
- 0
- Language
- en
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