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GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes

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Chan, Patricia P., Lowe, Todd M.·2016·Nucleic Acids Research

Abstract

Transfer RNAs represent the largest, most ubiquitous class of non-protein coding RNA genes found in all living organisms. The tRNAscan-SE search tool has become the de facto standard for annotating tRNA genes in genomes, and the Genomic tRNA Database (GtRNAdb) was created as a portal for interactive exploration of these gene predictions. Since its published description in 2009, the GtRNAdb has steadily grown in content, and remains the most commonly cited web-based source of tRNA gene information. In this update, we describe not only a major increase in the number of tRNA predictions (>367000) and genomes analyzed (>4370), but more importantly, the integration of new analytic and functional data to improve the quality and biological context of tRNA gene predictions. New information drawn from other sources includes tRNA modification data, epigenetic data, single nucleotide polymorphisms, gene expression and evolutionary conservation. A richer set of analytic data is also presented, including better tRNA functional prediction, non-canonical features, predicted structural impacts from sequence variants and minimum free energy structural predictions. Views of tRNA genes in genomic context are provided via direct links to the UCSC genome browsers. The database can be searched by sequence or gene features, and is available at http://gtrnadb.ucsc.edu/.

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Metadata

Authors
Chan, P. P., & Lowe, T. M.
Venue
Nucleic Acids Research
Published
2015-12-15
Volume
44
Issue
D1
Pages
D184-D189
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2223836536
Cited by
1,051
References
23
FWCI
13.64
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes. https://app.cochat.ai/papers/10.1093/nar/gkv1309
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Chan, P. P., & Lowe, T. M. (2016). GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes. Nucleic Acids Research. https://doi.org/10.1093/nar/gkv1309

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