The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
DIANA-miRPath v3.0: deciphering microRNA function with experimental support
Open accessAbstract
The functional characterization of miRNAs is still an open challenge. Here, we present DIANA-miRPath v3.0 (http://www.microrna.gr/miRPathv3) an online software suite dedicated to the assessment of miRNA regulatory roles and the identification of controlled pathways. The new miRPath web server renders possible the functional annotation of one or more miRNAs using standard (hypergeometric distributions), unbiased empirical distributions and/or meta-analysis statistics. DIANA-miRPath v3.0 database and functionality have been significantly extended to support all analyses for KEGG molecular pathways, as well as multiple slices of Gene Ontology (GO) in seven species (Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus and Danio rerio). Importantly, more than 600 000 experimentally supported miRNA targets from DIANA-TarBase v7.0 have been incorporated into the new schema. Users of DIANA-miRPath v3.0 can harness this wealth of information and substitute or combine the available in silico predicted targets from DIANA-microT-CDS and/or TargetScan v6.2 with high quality experimentally supported interactions. A unique feature of DIANA-miRPath v3.0 is its redesigned Reverse Search module, which enables users to identify and visualize miRNAs significantly controlling selected pathways or belonging to specific GO categories based on in silico or experimental data. DIANA-miRPath v3.0 is freely available to all users without any login requirement.
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Cites
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Gene Ontology: tool for the unification of biology
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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dbSNP: the NCBI database of genetic variation
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miRBase: annotating high confidence microRNAs using deep sequencing data
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Gene silencing by microRNAs: contributions of translational repression and mRNA decay
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mirPub: a database for searching microRNA publications
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Cited by
DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions
Karagkouni, D., Paraskevopoulou, M. D., Chatzopoulos, S., Vlachos, I. S., Tastsoglou, S., Kanellos, I., Papadimitriou, D., Kavakiotis, I., Maniou, S., Skoufos, G., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1141 · Cited by 1,135
Self-citationDIANA-LncBase v2: indexing microRNA targets on non-coding transcripts
Paraskevopoulou, M. D., Vlachos, I. S., Karagkouni, D., Georgakilas, G., Kanellos, I., Vergoulis, T., Zagganas, K., Tsanakas, P., Floros, E., Dalamagas, T., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1270 · Cited by 708
Self-citationCheng, X., Zhang, G., Zhang, L., Hu, Y., Zhang, K., Sun, X., Zhao, C., Li, H., Li, Y. M., & Zhao, J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13316 · Cited by 317
miRTargetLink 2.0—interactive miRNA target gene and target pathway networks
Kern, F., Aparicio-Puerta, E., Li, Y., Fehlmann, T., Kehl, T., Wagner, V., Ray, K., Ludwig, N., Lenhof, H.-P., Meese, E., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab297 · Cited by 205
Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E. A., Vialou, V., Ku, S. M., Gerald, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15497 · Cited by 201
Metadata
- Authors
- Vlachos, I. S., Zagganas, K., Paraskevopoulou, M. D., Georgakilas, G., Karagkouni, D., Vergoulis, T., Dalamagas, T., & Hatzigeorgiou, A. G.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-05-14
- Volume
- 43
- Issue
- W1
- Pages
- W460-W466
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1609044025
- Cited by
- 1,699
- References
- 7
- FWCI
- 34.54
- Type
- journal article
- Language
- en
- Open access
- gold
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