Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres

Udugama, Maheshi; Chang, Fiona T. M.; Chan, F. Lyn; Tang, Michelle C.; Pickett, Hilda A.; McGhie, James D. R.; Mayne, Lynne; Collas, Philippe; Mann, Jeffrey R.; Wong, Lee H.

doi:10.1093/nar/gkv847

Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres

In addition to being a hallmark at active genes, histone variant H3.3 is deposited by ATRX at repressive chromatin regions, including the telomeres. It is unclear how H3.3 promotes heterochromatin assembly. We show that H3.3 is targeted for K9 trimethylation to establish a heterochromatic state e…