Altered Telomeres in Tumors with ATRX and DAXX Mutations
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Chromosome tips seem to be maintained by an unusual mechanism in tumors that have mutations in chromatin remodeling genes.
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ALT is associated with mutations in ATRX in vitro and in several human cancers, including glioblastomas.
“ALT is associated with mutations in the chromatin remodeller α-thalassaemia/mental retardation syndrome X-linked (AT R X ) both in vitro and in several human cancers, including glioblastomas162–165.”
From Telomeres in cancer: tumour suppression and genome instability (2017) · cites this paper as [164]
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- Authors
- Heaphy, C. M., de Wilde, R. F., Jiao, Y., Klein, A. P., Edil, B. H., Shi, C., Bettegowda, C., Rodriguez, F. J., Eberhart, C. G., Hebbar, S., Offerhaus, G. J., McLendon, R., Rasheed, B. A., He, Y., Yan, H., Bigner, D. D., Oba-Shinjo, S. M., Marie, S. K. N., Riggins, G. J., Kinzler, K. W., Vogelstein, B., Hruban, R. H., Maitra, A., Papadopoulos, N., & Meeker, A. K.
- Affiliations
- Johns Hopkins University (US)
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
- Vanderbilt University (US)
- University Medical Center Utrecht (NL)
- Duke University (US)
- Department of Neurology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
- Universidade de São Paulo (BR)
- Corresponding author
- Heaphy, Christopher M.
- Jiao, Yuchen
- Papadopoulos, Nickolas
- Meeker, Alan K.
- ORCID
- Heaphy, Christopher M.
- Jiao, Yuchen
- Klein, Alison P.
- Edil, Barish H.
- Shi, Chanjuan
- Bettegowda, Chetan
- Eberhart, Charles G.
- Offerhaus, G. Johan
- McLendon, Roger
- He, Yiping
- Yan, Hai
- Bigner, Darell D.
- Marie, Suely Kazue Nagahashi
- Riggins, Gregory J.
- Kinzler, Kenneth W.
- Vogelstein, Bert
- Hruban, Ralph H.
- Maitra, Anirban
- Papadopoulos, Nickolas
- Meeker, Alan K.
- Venue
- Science
- Published
- 2011-07-22
- Volume
- 333
- Issue
- 6041
- Pages
- 425-425
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3174141
- OpenAlex
- W1986009297
- Cited by
- 1,083
- References
- 23
- Citations by year
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- FWCI
- 43.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.sciencemag.org
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ca121113-15, 5p50ns020023-30)
- National Cancer Institute (R01CA113669, R37CA011898, P01CA134292, R01-CA121113, R01CA140316, P50CA062924)
- National Institute of Neurological Disorders and Stroke (P50-NS020023, R01NS055089)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- ATRX, DAXX, telomeres, alternative lengthening of telomeres, telomere maintenance, pancreatic neuroendocrine tumors, chromatin remodeling, ATRX loss, central nervous system tumors, tumor suppressor
- MeSH terms
- X-linked Nuclear Protein, Cell Nucleus, DNA Helicases, Humans, Mutation, Nuclear Proteins, Pancreatic Neoplasms, Phenotype, Central Nervous System Neoplasms, Telomere, In Situ Hybridization, Fluorescence, Carcinoma, Neuroendocrine, Molecular Chaperones, Chromatin Assembly and Disassembly, Adaptor Proteins, Signal Transducing, Mutant Proteins, Co-Repressor Proteins
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