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CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database

Open access
Jia, Baofeng, Raphenya, Amogelang R., Alcock, Brian, Waglechner, Nicholas, Guo, Peiyao, Tsang, Kara K., Lago, Briony A., Dave, Biren M., Pereira, Sheldon, Sharma, Arjun N., Doshi, Sachin, Courtot, Mélanie, Lo, Raymond, Williams, Laura E., Frye, Jonathan G., Elsayegh, Tariq, Sardar, Daim, Westman, Erin L., Pawlowski, Andrew C., Johnson, Timothy A., Brinkman, Fiona S.L., Wright, Gerard D., McArthur, Andrew G.·2017·Nucleic Acids Research

Abstract

The Comprehensive Antibiotic Resistance Database (CARD; http://arpcard.mcmaster.ca) is a manually curated resource containing high quality reference data on the molecular basis of antimicrobial resistance (AMR), with an emphasis on the genes, proteins and mutations involved in AMR. CARD is ontologically structured, model centric, and spans the breadth of AMR drug classes and resistance mechanisms, including intrinsic, mutation-driven and acquired resistance. It is built upon the Antibiotic Resistance Ontology (ARO), a custom built, interconnected and hierarchical controlled vocabulary allowing advanced data sharing and organization. Its design allows the development of novel genome analysis tools, such as the Resistance Gene Identifier (RGI) for resistome prediction from raw genome sequence. Recent improvements include extensive curation of additional reference sequences and mutations, development of a unique Model Ontology and accompanying AMR detection models to power sequence analysis, new visualization tools, and expansion of the RGI for detection of emergent AMR threats. CARD curation is updated monthly based on an interplay of manual literature curation, computational text mining, and genome analysis.

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Research works printed but not linked: 17

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Metadata

Authors
Jia, B., Raphenya, A. R., Alcock, B., Waglechner, N., Guo, P., Tsang, K. K., Lago, B. A., Dave, B. M., Pereira, S., Sharma, A. N., Doshi, S., Courtot, M., Lo, R., Williams, L. E., Frye, J. G., Elsayegh, T., Sardar, D., Westman, E. L., Pawlowski, A. C., Johnson, T. A., Brinkman, F. S. L., Wright, G. D., & McArthur, A. G.
Venue
Nucleic Acids Research
Published
2016-10-26
Volume
45
Issue
D1
Pages
D566-D573
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2544493586
Cited by
2,661
References
2
FWCI
82.11
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. https://app.cochat.ai/papers/10.1093/nar/gkw1004
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Jia, B., Raphenya, A. R., Alcock, B., Waglechner, N., Guo, P., Tsang, K. K., Lago, B. A., Dave, B. M., Pereira, S., Sharma, A. N., Doshi, S., Courtot, M., Lo, R., Williams, L. E., Frye, J. G., Elsayegh, T., Sardar, D., Westman, E. L., Pawlowski, A. C., . . . McArthur, A. G. (2017). CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Research. https://doi.org/10.1093/nar/gkw1004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.