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FuzDB: database of fuzzy complexes, a tool to develop stochastic structure-function relationships for protein complexes and higher-order assemblies
Open accessAbstract
FuzDB (http://protdyn-database.org) compiles experimentally observed fuzzy protein complexes, where intrinsic disorder (ID) is maintained upon interacting with a partner (protein, nucleic acid or small molecule) and directly impacts biological function. Entries in the database have both (i) structural evidence demonstrating the structural multiplicity or dynamic disorder of the ID region(s) in the partner bound form of the protein and (ii) in vitro or in vivo biological evidence that indicates the significance of the fuzzy region(s) in the formation, function or regulation of the assembly. Unlike the other intrinsically disordered or unfolded protein databases, FuzDB focuses on ID regions within a biological context, including higher-order assemblies and presents a detailed analysis of the structural and functional data. FuzDB also provides interpretation of experimental results to elucidate the molecular mechanisms by which fuzzy regions-classified on the basis of topology and mechanism-interfere with the structural ensembles and activity of protein assemblies. Regulatory sites generated by alternative splicing (AS) or post-translational modifications (PTMs) are also collected. By assembling all this information, FuzDB could be utilized to develop stochastic structure-function relationships for proteins and could contribute to the emergence of a new paradigm.
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“since many (not all) IDRs can undergo coupled folding and binding into context-specific threedimensional structures, 26,45”
From AlphaFold and Implications for Intrinsically Disordered Proteins (2021) · cites this paper as [26]
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Metadata
- Authors
- Miskei, M., Antal, C., & Fuxreiter, M.
- Affiliations
- University of Debrecen (HU)
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-10-28
- Volume
- 45
- Issue
- D1
- Pages
- D228-D235
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC5210525
- OpenAlex
- W2541950838
- Cited by
- 119
- References
- 30
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 6 · 2023: 11 · 2022: 8 · 2021: 9 · 2020: 20 · 2019: 21 · 2018: 19 · 2017: 15
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Magyar Tudományos Akadémia
- Debreceni Egyetem
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Keywords
- fuzzy complexes, intrinsically disordered proteins, protein complexes, structural ensembles, protein-protein interaction, alternative splicing, post-translational modification, protein-ligand interactions
- MeSH terms
- Carrier Proteins, Models, Molecular, Protein Binding, Proteins, Software, Structure-Activity Relationship, Computational Biology, Databases, Protein, Multiprotein Complexes, Web Browser
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